Relationships of Office, Ambulatory, and Self-measured Blood Pressure With Cardiac, Renal, and Atherosclerotic Biomarkers.

IF 3.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE American Journal of Hypertension Pub Date : 2024-09-16 DOI:10.1093/ajh/hpae083
Keisuke Narita, Satoshi Hoshide, Kazuomi Kario
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Abstract

Background: Previous studies with several limitations have comparatively analyzed the relationship between ambulatory blood pressure (BP) and self-measured BP and biomarkers of organ damage. This study extends this line of research by examining the relationship between ambulatory and self-measured BP and cardiac, renal, and atherosclerotic biomarkers in outpatients at cardiovascular risk.

Methods: In 1,440 practice outpatients who underwent office, ambulatory, and self-measured BP monitoring, we assessed the relationships of each BP with organ damage biomarkers including b-type natriuretic peptide (BNP), echocardiographic left ventricular mass index (LVMI), urine albumin-creatinine ratio (UACR), and brachial-ankle pulse wave velocity (baPWV).

Results: In the comparison of correlation, self-measured systolic BP (SBP) was more strongly correlated to log-transformed (Ln) BNP (n = 1,435; r = 0.123 vs. r = -0.093, P < 0.001), LVMI (n = 1,278; r = 0.223 vs. r = 0.094, P < 0.001), Ln-UACR (n = 1,435; r = 0.244 vs. r = 0.154, P = 0.010), and baPWV (n = 1,360; r = 0.327 vs. r = 0.115, P < 0.001) than daytime ambulatory SBP. In the linear regression models including office, ambulatory, and self-measured SBP, only self-measured SBP was significantly related to Ln-BNP (P = 0.016) and LVMI (P < 0.001). In the logistic regression models for the top quartile of LVMI, adding self-measured SBP improved the model predictability (P = 0.027), but adding daytime ambulatory SBP did not. However, adding daytime ambulatory SBP improved the model predictability in the logistic model for the top quartile of baPWV including office and self-measured SBP (P = 0.030).

Conclusions: Our study findings suggested that self-measured BP was associated with cardiac biomarkers independent of ambulatory BP.

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诊室血压、门诊血压和自测血压与心脏、肾脏和动脉粥样硬化生物标志物的关系。
背景:以往的研究对非卧床血压(BP)和自我测量血压与器官损伤生物标志物之间的关系进行了比较分析,但存在一些局限性。本研究扩展了这一研究思路,研究了心血管风险门诊患者的动态血压和自测血压与心脏、肾脏和动脉粥样硬化生物标志物之间的关系:我们对 1440 名门诊患者进行了诊室、门诊和自测血压监测,评估了各血压与器官损伤生物标志物(包括 b 型钠尿肽 (BNP)、超声心动图左心室质量指数 (LVMI)、尿-白蛋白-肌酐比值 (UACR) 和肱踝脉搏波速度 (baPWV) 等)之间的关系:在相关性比较中,自我测量的收缩压(SBP)与对数转换(Ln)BNP(n=1,435;r=0.123 vs. r = -0.093,PC结论)的相关性更强:我们的研究结果表明,自测血压与心脏生物标志物相关,而与卧床血压无关。
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来源期刊
American Journal of Hypertension
American Journal of Hypertension 医学-外周血管病
CiteScore
6.90
自引率
6.20%
发文量
144
审稿时长
3-8 weeks
期刊介绍: The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
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