Oral Mucosa and Saliva Alterations Related to Vape

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2024-07-05 DOI:10.1002/cre2.926

Bruna Fernandes do Carmo Carvalho, Natália de Carvalho Faria, Letícia Foiani, Gabrielle Luana Jimenez Teodoro Nepomuceno, Desirée Rosa Cavalcanti, Mônica Ghislaine Oliveira Alves, Herculano da Silva Martinho, Mário Pérez-Sayáns, Janete Dias Almeida

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Abstract

Objectives

Electronic nicotine delivery systems (e-cigarette, pod, and vape) are currently among the tobacco consumption of adolescents and young adults. The aim is to show oral mucosa and saliva alterations related to vape.

Material and Methods

A vape-user patient, presenting a white plaque in the posterior region of the hard palate, underwent clinical examination, sialometry, pH evaluation, and excisional biopsy of the white lesion. Molecular changes in saliva and vape liquid were analyzed by vibrational spectroscopy.

Results

The histopathological analyses showed hyperparakeratosis without dysplasia. Formaldehyde, ketones, and aromatic hydrocarbon species were identified in e-cig liquid by the FTIR.

Conclusions

The use of vape may be related to the development of hyperkeratotic lesions in the oral mucosa as well as significantly modify the patient's salivary patterns as the vape liquid presents carcinogenic and cytotoxic components in its composition.

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与 Vape 有关的口腔黏膜和唾液变化。

目的：电子尼古丁递送系统（电子烟、pod 和 vape）目前是青少年和年轻人的烟草消费之一。材料和方法：对一名在硬腭后部出现白色斑块的吸食者进行了临床检查、唾液测定、pH 值评估和白色病变切除活检。通过振动光谱分析了唾液和吸食液中的分子变化：结果：组织病理学分析表明牙周角化过度，但无发育不良。傅立叶变换红外光谱分析确定了电子烟液体中的甲醛、酮和芳香烃：使用电子烟可能与口腔黏膜角化过度病变的发生有关，并且由于电子烟液的成分中含有致癌和细胞毒性成分，会显著改变患者的唾液模式。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.