Echocardiography Core Laboratory Methodology for TAVR

IF 15.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS JACC. Cardiovascular imaging Pub Date : 2024-12-01 DOI:10.1016/j.jcmg.2024.04.014

Claire B. Ren MD, PhD , Danielle Tardif BS , Hans-Jelle Brandenburg BS , Mathieu Roux BS , Blaz Mrevlje MD, PhD , Marcel L. Geleijnse MD, PhD , Nicolas M. Van Mieghem MD, PhD , Ernest Spitzer MD , Philippe Pibarot DVM, PhD

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Abstract

Inter-echocardiography core laboratory (ECL) harmonization is pivotal to consider data from different ECLs interchangeable. On the basis of the experience of the first trans-Atlantic harmonization of 2 established ECLs in the field of transcatheter aortic valve replacement (TAVR) trials, this review describes the harmonized ECL methodology in analyzing and adjudicating the post-TAVR echocardiographic endpoints according to Valve Academic Research Consortium 3 definitions. This review presents the feasibility and intra- and inter-ECL reproducibility, explains the root cause of potential important inter-ECL variability, and formulates ECL recommendations for optimal post-TAVR echocardiographic image acquisition. The implementation of inter-ECL harmonization may further define the best practice of ECLs and have logistic and regulatory implications for the realization of future TAVR trials.

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TAVR 超声心动图核心实验室方法：跨大西洋共识。

超声心动图核心实验室（ECL）间的协调对于不同 ECL 的数据互换至关重要。本综述以经导管主动脉瓣置换术（TAVR）试验领域两家成熟的 ECL 首次跨大西洋协调的经验为基础，介绍了根据瓣膜学术研究联盟 3 的定义分析和判定 TAVR 术后超声心动图终点的协调 ECL 方法。本综述介绍了 ECL 的可行性、ECL 内和 ECL 间的可重复性，解释了 ECL 间潜在重要变异的根本原因，并提出了优化 TAVR 术后超声心动图图像采集的 ECL 建议。ECL间协调的实施可能会进一步确定ECL的最佳实践，并对未来TAVR试验的实现产生后勤和监管方面的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC. Cardiovascular imaging CARDIAC & CARDIOVASCULAR SYSTEMS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

24.90

自引率

5.70%

发文量

330

审稿时长

4-8 weeks

期刊介绍： JACC: Cardiovascular Imaging, part of the prestigious Journal of the American College of Cardiology (JACC) family, offers readers a comprehensive perspective on all aspects of cardiovascular imaging. This specialist journal covers original clinical research on both non-invasive and invasive imaging techniques, including echocardiography, CT, CMR, nuclear, optical imaging, and cine-angiography. JACC. Cardiovascular imaging highlights advances in basic science and molecular imaging that are expected to significantly impact clinical practice in the next decade. This influence encompasses improvements in diagnostic performance, enhanced understanding of the pathogenetic basis of diseases, and advancements in therapy. In addition to cutting-edge research,the content of JACC: Cardiovascular Imaging emphasizes practical aspects for the practicing cardiologist, including advocacy and practice management.The journal also features state-of-the-art reviews, ensuring a well-rounded and insightful resource for professionals in the field of cardiovascular imaging.