Pub Date : 2026-03-23DOI: 10.1016/j.jcmg.2026.02.014
Leonardo Portolan, Rafail A. Kotronias, Stefano Andreaggi, Alessandro Maino, Jason Walsh, Marios Antoniadis, Gautham Rao, Cheng Xie, Sheena Thomas, Kenneth Chan, Jeremy P. Langrish, Andrew Lucking, Jonathan Denton, Robyn Farrall, Nikant Sabharwal, David A. Holdsworth, Thomas Halborg, Stefan Neubauer, Adrian P. Banning, Keith M. Channon, Charalambos Antoniades, Giovanni Luigi De Maria
{"title":"Standard and Ultrahigh Resolution Photon-Counting Coronary CTA–Derived FFR Against Invasive FFR Assessment","authors":"Leonardo Portolan, Rafail A. Kotronias, Stefano Andreaggi, Alessandro Maino, Jason Walsh, Marios Antoniadis, Gautham Rao, Cheng Xie, Sheena Thomas, Kenneth Chan, Jeremy P. Langrish, Andrew Lucking, Jonathan Denton, Robyn Farrall, Nikant Sabharwal, David A. Holdsworth, Thomas Halborg, Stefan Neubauer, Adrian P. Banning, Keith M. Channon, Charalambos Antoniades, Giovanni Luigi De Maria","doi":"10.1016/j.jcmg.2026.02.014","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.02.014","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"20 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-19DOI: 10.1016/j.jcmg.2026.02.007
Phyo H Khaing,Menaka Mahendran,Suvasini Lakshmanan,Dorien M Kimenai,Marie de Bakker,Krystalina Sim,Kayleigh Wood,Marc R Dweck,Nicholas L Mills,David E Newby,Michelle C Williams
{"title":"Sex Differences in Long-Term Outcomes of Coronary CT-Guided Management for Stable Chest Pain: Insights From the SCOT-HEART Trial.","authors":"Phyo H Khaing,Menaka Mahendran,Suvasini Lakshmanan,Dorien M Kimenai,Marie de Bakker,Krystalina Sim,Kayleigh Wood,Marc R Dweck,Nicholas L Mills,David E Newby,Michelle C Williams","doi":"10.1016/j.jcmg.2026.02.007","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.02.007","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"1 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-18DOI: 10.1016/j.jcmg.2026.02.004
Sina Fathieh,Michael P Gray,Max Kirkby,Elijah Genetzakis,Alireza Gholipour,Christopher Poole,Peter J Psaltis,David E Newby,Pamela S Douglas,Ron Blankstein,Matthew J Budoff,Kelley Branch,Andrew J Buckler,Gemma A Figtree,Stuart M Grieve
Spotty calcification is a marker of microcalcification in coronary artery plaques, where it becomes large enough to be visible on imaging modalities such as computed tomography. Two prevailing hypotheses posit spotty calcification as either a passive indicator of unstable plaque or an active catalyst of plaque vulnerability. Alongside this conceptual development, there has been paired evolution in radiologic characterization, with various imaging modalities demonstrating commendable accuracy in identifying spotty calcification. Many studies have linked the presence of spotty calcification to plaque instability and have reported a higher frequency in culprit lesions leading to acute coronary syndrome. Researchers have thus explored medications such as statins, metformin, and omega-3 fatty acids for their impact on the development and progression of spotty calcification. However, the field lacks standardized definitions that will enhance the clinical utility of this finding. This paper summarizes the evidence that describes spotty calcification as a unique plaque phenotype, its radiologic characteristics on routine cardiac imaging modalities, and its clinical relevance as a novel radiomarker of vulnerable coronary artery disease. This paper benefits from a systematic review of the evidence and, where possible, meta-analysis of the available data to address key questions conclusively in each of 3 areas of interest.
{"title":"Biological, Radiological, and Clinical Significance of Spotty Calcification in Coronary Artery Disease: A State-of-the-Art Review.","authors":"Sina Fathieh,Michael P Gray,Max Kirkby,Elijah Genetzakis,Alireza Gholipour,Christopher Poole,Peter J Psaltis,David E Newby,Pamela S Douglas,Ron Blankstein,Matthew J Budoff,Kelley Branch,Andrew J Buckler,Gemma A Figtree,Stuart M Grieve","doi":"10.1016/j.jcmg.2026.02.004","DOIUrl":"https://doi.org/10.1016/j.jcmg.2026.02.004","url":null,"abstract":"Spotty calcification is a marker of microcalcification in coronary artery plaques, where it becomes large enough to be visible on imaging modalities such as computed tomography. Two prevailing hypotheses posit spotty calcification as either a passive indicator of unstable plaque or an active catalyst of plaque vulnerability. Alongside this conceptual development, there has been paired evolution in radiologic characterization, with various imaging modalities demonstrating commendable accuracy in identifying spotty calcification. Many studies have linked the presence of spotty calcification to plaque instability and have reported a higher frequency in culprit lesions leading to acute coronary syndrome. Researchers have thus explored medications such as statins, metformin, and omega-3 fatty acids for their impact on the development and progression of spotty calcification. However, the field lacks standardized definitions that will enhance the clinical utility of this finding. This paper summarizes the evidence that describes spotty calcification as a unique plaque phenotype, its radiologic characteristics on routine cardiac imaging modalities, and its clinical relevance as a novel radiomarker of vulnerable coronary artery disease. This paper benefits from a systematic review of the evidence and, where possible, meta-analysis of the available data to address key questions conclusively in each of 3 areas of interest.","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"12 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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