Pub Date : 2026-01-12DOI: 10.1016/j.jcmg.2025.11.009
Jacob Abdaem,Dina Labib,Rhys Beaudry,Augustine Amakiri,Steven Dykstra,Yuanchao Feng,Melanie King,Jacqueline Flewitt,Danielle A Southern,Matthew T James,Stephen B Wilton,Carmen P Lydell,Andrew G Howarth,Bryan J Har,James A White,Robert J H Miller
BACKGROUNDViability testing is frequently used in patients with ischemic cardiomyopathy (ICM). However, its role in guiding revascularization decisions remains unclear.OBJECTIVESThis study aimed to evaluate the associations between a novel, segmentally registered viability and vascular jeopardy score and mortality following revascularization.METHODSThe study included patients with ICM, defined as obstructive coronary artery disease and LVEF <50%, undergoing cardiac magnetic resonance and invasive coronary angiography between 2015 and 2022. Segmental viability was defined as scar transmurality ≤50% detected by cardiac magnetic resonance. Spatially matched distributions of vascular perfusion jeopardy were established at the time of angiography by using a patient-specific coronary anatomy tree and lesion reporting algorithm. Interactions between viability extent, coronary artery disease severity, the novel marker of jeopardized but viable myocardium, and early revascularization were assessed using propensity score-adjusted time-to-event models for mortality.RESULTSOf 941 patients (mean age 65 years; 81% male), 193 underwent early revascularization. During a median follow-up of 4.8 years, 168 deaths occurred. There were no interactions between the number of viable segments and revascularization (interaction HR: 1.09; P = 0.211) or between the Duke jeopardy score and revascularization (interaction HR: 0.93; P = 0.245) with respect to future mortality. However, a significant interaction was identified for the number of jeopardized but viable segments (interaction HR: 0.91; P = 0.008). Patients with ≥3 jeopardized but viable segments experienced significantly lower mortality following early revascularization (propensity score-adjusted HR: 0.55; P = 0.015).CONCLUSIONSPatient-specific coronary tree-based reporting to define jeopardized but viable myocardium accurately is clinically feasible and identifies ICM patients who experience lower mortality from early revascularization.
{"title":"Patient-Specific Registration of Segmental Jeopardy and Viability: Novel Method to Guide Revascularization in Ischemic Cardiomyopathy.","authors":"Jacob Abdaem,Dina Labib,Rhys Beaudry,Augustine Amakiri,Steven Dykstra,Yuanchao Feng,Melanie King,Jacqueline Flewitt,Danielle A Southern,Matthew T James,Stephen B Wilton,Carmen P Lydell,Andrew G Howarth,Bryan J Har,James A White,Robert J H Miller","doi":"10.1016/j.jcmg.2025.11.009","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.11.009","url":null,"abstract":"BACKGROUNDViability testing is frequently used in patients with ischemic cardiomyopathy (ICM). However, its role in guiding revascularization decisions remains unclear.OBJECTIVESThis study aimed to evaluate the associations between a novel, segmentally registered viability and vascular jeopardy score and mortality following revascularization.METHODSThe study included patients with ICM, defined as obstructive coronary artery disease and LVEF <50%, undergoing cardiac magnetic resonance and invasive coronary angiography between 2015 and 2022. Segmental viability was defined as scar transmurality ≤50% detected by cardiac magnetic resonance. Spatially matched distributions of vascular perfusion jeopardy were established at the time of angiography by using a patient-specific coronary anatomy tree and lesion reporting algorithm. Interactions between viability extent, coronary artery disease severity, the novel marker of jeopardized but viable myocardium, and early revascularization were assessed using propensity score-adjusted time-to-event models for mortality.RESULTSOf 941 patients (mean age 65 years; 81% male), 193 underwent early revascularization. During a median follow-up of 4.8 years, 168 deaths occurred. There were no interactions between the number of viable segments and revascularization (interaction HR: 1.09; P = 0.211) or between the Duke jeopardy score and revascularization (interaction HR: 0.93; P = 0.245) with respect to future mortality. However, a significant interaction was identified for the number of jeopardized but viable segments (interaction HR: 0.91; P = 0.008). Patients with ≥3 jeopardized but viable segments experienced significantly lower mortality following early revascularization (propensity score-adjusted HR: 0.55; P = 0.015).CONCLUSIONSPatient-specific coronary tree-based reporting to define jeopardized but viable myocardium accurately is clinically feasible and identifies ICM patients who experience lower mortality from early revascularization.","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"29 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145956052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1016/j.jcmg.2025.12.003
Eike Nagel
{"title":"Stress CMR in ISCHEMIA: Function in Its Best Form.","authors":"Eike Nagel","doi":"10.1016/j.jcmg.2025.12.003","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.12.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"29 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1016/j.jcmg.2025.12.006
Robert S Zhang,Jonathan W Weinsaft
{"title":"Just When We Thought Viability Was in Jeopardy.","authors":"Robert S Zhang,Jonathan W Weinsaft","doi":"10.1016/j.jcmg.2025.12.006","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.12.006","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"56 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.jcmg.2025.12.005
Andre La Gerche, Stephanie J. Rowe
{"title":"Moving From Eyeball Assessment to Quantification of the Right Ventricular “Hot Spot” in Arrhythmogenic Cardiomyopathy","authors":"Andre La Gerche, Stephanie J. Rowe","doi":"10.1016/j.jcmg.2025.12.005","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.12.005","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-05DOI: 10.1016/j.jcmg.2025.12.004
Paul A. Grayburn
{"title":"Impaired Right Ventricular Function After Transcatheter Treatment of Tricuspid Regurgitation","authors":"Paul A. Grayburn","doi":"10.1016/j.jcmg.2025.12.004","DOIUrl":"https://doi.org/10.1016/j.jcmg.2025.12.004","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"98 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-01DOI: 10.1016/j.jcmg.2025.07.003
Sarah Malik MD , Doosup Shin MD , Emma Caron BSc, Rick H.J.A. Volleberg MD, Koshiro Sakai MD, PhD, Carlos Collet MD, PhD, Evan Shlofmitz DO, Allen Jeremias MD, MSc, Ziad A. Ali MD, DPhil , Omar K. Khalique MD
{"title":"Validation of Coronary Stent Measurements Using Photon-Counting Detector Computed Tomography","authors":"Sarah Malik MD , Doosup Shin MD , Emma Caron BSc, Rick H.J.A. Volleberg MD, Koshiro Sakai MD, PhD, Carlos Collet MD, PhD, Evan Shlofmitz DO, Allen Jeremias MD, MSc, Ziad A. Ali MD, DPhil , Omar K. Khalique MD","doi":"10.1016/j.jcmg.2025.07.003","DOIUrl":"10.1016/j.jcmg.2025.07.003","url":null,"abstract":"","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 1","pages":"Pages 126-129"},"PeriodicalIF":15.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronary computed tomography angiography (CTA)-derived plaque burden is associated with the risk of cardiovascular events and is expected to be used in clinical practice. Understanding the normative values of computed tomography–based quantitative plaque volume in the general population is clinically important for determining patient management.
Objectives
This study aimed to investigate the distribution of plaque volume in the general population and to develop nomograms using MiHEART (Miami Heart Study) at Baptist Health South Florida, a large community-based cohort study.
Methods
The study included 2,301 asymptomatic subjects without cardiovascular disease enrolled in MiHEART. Quantitative assessment of plaque volume was performed by using artificial intelligence–guided quantitative coronary computed tomography angiography (AI-QCT) analysis. The percentiles of the plaque distribution were estimated with nonparametric techniques.
Results
Mean age of the participants was 53.5 years, and 50.4% were male. The median total plaque volume was 54 mm3 (Q1-Q3: 16-126 mm3) and increased with age. Male subjects had greater median total plaque volume than female subjects (80 mm3 [Q1-Q3: 31-181 mm3] vs 34 mm3 [Q1-Q3: 9-85 mm3]; P < 0.001); there was no difference according to race/ethnicity (Hispanic 53 mm3 [Q1-Q3: 14-119 mm3] vs non-Hispanic 54 mm3 [Q1-Q3: 17-127 mm3]; P = 0.756). The prevalence of subjects with total plaque volume ≥20 mm3 was 81.5% in male subjects and 61.9% in female subjects. Younger individuals had a greater percentage of noncalcified plaque.
Conclusions
The large majority of study subjects had plaque detected by using AI-QCT. Furthermore, age- and sex-specific nomograms provided information on the plaque volume distribution in an asymptomatic population. (Miami Heart Study [MiHEART] at Baptist Health South Florida; NCT02508454)
背景冠状动脉ct血管造影（CTA）所得斑块负担与心血管事件风险相关，有望用于临床实践。了解普通人群中基于计算机断层扫描的定量斑块体积的规范值对于确定患者管理具有重要的临床意义。目的：本研究旨在调查斑块体积在普通人群中的分布，并利用MiHEART（迈阿密心脏研究）在南佛罗里达浸信会健康中心开展一项大型社区队列研究。方法该研究纳入了2301名无心血管疾病的无症状受试者。通过人工智能引导的定量冠状动脉计算机断层血管造影（AI-QCT）分析对斑块体积进行定量评估。用非参数技术估计斑块分布的百分位数。结果参与者平均年龄53.5岁，男性占50.4%。中位总斑块体积为54 mm3 (Q1-Q3: 16-126 mm3)，随着年龄的增长而增加。男性受试者的中位总斑块体积大于女性受试者（80 mm3 [Q1-Q3: 31-181 mm3] vs 34 mm3 [Q1-Q3: 9-85 mm3], P < 0.001）；根据种族/民族没有差异（西班牙裔53 mm3 [Q1-Q3: 14-119 mm3]与非西班牙裔54 mm3 [Q1-Q3: 17-127 mm3]； P = 0.756）。总斑块体积≥20mm3的男性患病率为81.5%，女性患病率为61.9%。年轻人的非钙化斑块比例更高。结论AI-QCT可检测到绝大多数研究对象的斑块。此外，年龄和性别特异性的形态图提供了无症状人群中斑块体积分布的信息。（迈阿密心脏研究[MiHEART]浸信会健康南佛罗里达；NCT02508454）。
{"title":"Coronary Plaque Volume in an Asymptomatic Population","authors":"Keishi Ichikawa MD, PhD , Shai Ronen PhD , Rachelle Bishay BS , Srikanth Krishnan MD, MSc , Travis Benzing MD , Sina Kianoush MD , Jairo Aldana-Bitar MD , Miguel Cainzos-Achirica MD, MPH, PhD , Theodore Feldman MD , Jonathan Fialkow MD , Matthew J. Budoff MD , Khurram Nasir MD, MPH, MSc","doi":"10.1016/j.jcmg.2025.08.001","DOIUrl":"10.1016/j.jcmg.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Coronary computed tomography angiography (CTA)-derived plaque burden is associated with the risk of cardiovascular events and is expected to be used in clinical practice. Understanding the normative values of computed tomography–based quantitative plaque volume in the general population is clinically important for determining patient management.</div></div><div><h3>Objectives</h3><div>This study aimed to investigate the distribution of plaque volume in the general population and to develop nomograms using MiHEART (Miami Heart Study) at Baptist Health South Florida, a large community-based cohort study.</div></div><div><h3>Methods</h3><div>The study included 2,301 asymptomatic subjects without cardiovascular disease enrolled in MiHEART. Quantitative assessment of plaque volume was performed by using artificial intelligence–guided quantitative coronary computed tomography angiography (AI-QCT) analysis. The percentiles of the plaque distribution were estimated with nonparametric techniques.</div></div><div><h3>Results</h3><div>Mean age of the participants was 53.5 years, and 50.4% were male. The median total plaque volume was 54 mm<sup>3</sup> (Q1-Q3: 16-126 mm<sup>3</sup>) and increased with age. Male subjects had greater median total plaque volume than female subjects (80 mm<sup>3</sup> [Q1-Q3: 31-181 mm<sup>3</sup>] vs 34 mm<sup>3</sup> [Q1-Q3: 9-85 mm<sup>3</sup>]; <em>P <</em> 0.001); there was no difference according to race/ethnicity (Hispanic 53 mm<sup>3</sup> [Q1-Q3: 14-119 mm<sup>3</sup>] vs non-Hispanic 54 mm<sup>3</sup> [Q1-Q3: 17-127 mm<sup>3</sup>]; <em>P =</em> 0.756). The prevalence of subjects with total plaque volume ≥20 mm<sup>3</sup> was 81.5% in male subjects and 61.9% in female subjects. Younger individuals had a greater percentage of noncalcified plaque.</div></div><div><h3>Conclusions</h3><div>The large majority of study subjects had plaque detected by using AI-QCT. Furthermore, age- and sex-specific nomograms provided information on the plaque volume distribution in an asymptomatic population. (Miami Heart Study [MiHEART] at Baptist Health South Florida; <span><span>NCT02508454</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14767,"journal":{"name":"JACC. Cardiovascular imaging","volume":"19 1","pages":"Pages 49-60"},"PeriodicalIF":15.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：