Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously

IF 8.6 2区 化学 Q1 Chemistry Topics in Current Chemistry Pub Date : 2024-07-06 DOI:10.1007/s41061-024-00467-8
Kevin R. Venrooij, Lucienne de Bondt, Kimberly M. Bonger
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Abstract

Bioorthogonal click chemistry has played a transformative role in many research fields, including chemistry, biology, and medicine. Click reactions are crucial to produce increasingly complex bioconjugates, to visualize and manipulate biomolecules in living systems and for various applications in bioengineering and drug delivery. As biological (model) systems grow more complex, researchers have an increasing need for using multiple orthogonal click reactions simultaneously. In this review, we will introduce the most common bioorthogonal reactions and discuss their orthogonal use on the basis of their mechanism and electronic or steric tuning. We provide an overview of strategies to create reaction orthogonality and show recent examples of mutual orthogonal chemistry used for simultaneous biomolecule labeling. We end by discussing some considerations for the type of chemistry needed for labeling biomolecules in a system of choice.

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相互正交的生物正交反应:同时标记多种生物分子的选择性化学。
生物正交点击化学在化学、生物学和医学等多个研究领域发挥了变革性作用。点击反应对于生产日益复杂的生物共轭物、可视化和操纵活体系统中的生物分子以及生物工程和给药领域的各种应用至关重要。随着生物(模型)系统越来越复杂,研究人员越来越需要同时使用多种正交点击反应。在本综述中,我们将介绍最常见的生物正交反应,并根据其机理和电子或立体调谐讨论其正交用途。我们将概述创造反应正交性的策略,并展示最近用于同时标记生物分子的相互正交化学实例。最后,我们将讨论在所选体系中标记生物大分子所需的化学类型的一些注意事项。
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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