Drug release and physical properties of double layers coated contact lenses using natural polymers

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE Macromolecular Research Pub Date : 2024-07-04 DOI:10.1007/s13233-024-00289-z

Hye Ji Kim, Hyun Mee Lee

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Abstract

This study aims to develop contact lenses with improved drug-release duration time by layer-by-layer (LBL) coating with natural polymers on contact lenses containing the drug gatifloxacin. LBL coating was performed in single and double layers on contact lenses containing gatifloxaxin using natural polymers carrageenan and polylysine. The performance of contact lenses was evaluated based on various physical properties and antibacterial properties. As a result, contact lenses containing gatifloxacin have reduced physical properties compared to lenses without gatifloxacin. As the concentration of gatifloxacin increased, oxygen permeability and wettability decreased, and antibacterial properties increased. LBL coating improved the wettability and antibacterial properties of contact lenses and increased the drug-release duration. Double-layers coated lenses increased the duration of drug release more than single-coated lenses.

Graphic Abstract

Double layer-coating with poly-L-lysine and carrageenan on contact lenses

Abstract Image

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使用天然聚合物的双层镀膜隐形眼镜的药物释放和物理特性

本研究旨在通过在含有药物加替沙星的隐形眼镜上使用天然聚合物进行逐层涂布（LBL），开发出药物释放持续时间更长的隐形眼镜。使用天然聚合物卡拉胶和聚赖氨酸对含有加替沙星的隐形眼镜进行了单层和双层 LBL 涂层。根据各种物理特性和抗菌特性对隐形眼镜的性能进行了评估。结果显示，与不含加替沙星的隐形眼镜相比，含加替沙星的隐形眼镜的物理性质有所下降。随着加替沙星浓度的增加，透氧性和润湿性降低，而抗菌性增加。LBL 涂层改善了隐形眼镜的润湿性和抗菌性，并延长了药物释放时间。双层镀膜镜片比单层镀膜镜片更能延长药物释放的持续时间。图文摘要隐形眼镜上的聚左旋赖氨酸和卡拉胶双层镀膜

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.