Astrocytic NMDA Receptors

IF 2.3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow) Pub Date : 2024-07-04 DOI:10.1134/S0006297924060063
Artem M. Kosenkov, Sergei A. Maiorov, Sergei G. Gaidin
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Abstract

Astrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition. Astrocytic NMDARs are characterized by a low sensitivity to magnesium ions and low calcium conductivity. Their activation plays an important role in the regulation of various intracellular processes, such as gene expression and mitochondrial function. Astrocytic NMDARs are involved in calcium signaling in astrocytes and can act through the ionotropic and metabotropic pathways. Astrocytic NMDARs participate in the interactions of the neuroglia, thus affecting synaptic plasticity. They are also engaged in the astrocyte-vascular interactions and contribute to the regulation of vascular tone. Astrocytic NMDARs are involved in various pathologies, such as ischemia and hyperammonemia, and their blockade prevents negative changes in astrocytes during these diseases.

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星形胶质细胞 NMDA 受体
摘要星形胶质细胞 NMDA 受体(NMDARs)是一种异源四聚体,其表达和特性主要由其亚基组成决定。星形胶质细胞 NMDARs 的特点是对镁离子的敏感性低和钙传导性低。它们的激活在调节基因表达和线粒体功能等各种细胞内过程中发挥着重要作用。星形胶质细胞 NMDARs 参与星形胶质细胞的钙信号转导,可通过离子和代谢途径发挥作用。星形胶质细胞 NMDARs 参与神经胶质细胞的相互作用,从而影响突触的可塑性。它们还参与星形胶质细胞与血管的相互作用,有助于调节血管张力。星形胶质细胞 NMDARs 与缺血和高氨血症等多种病症有关,阻断它们可防止星形胶质细胞在这些疾病中发生负面变化。
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来源期刊
Biochemistry (Moscow)
Biochemistry (Moscow) 生物-生化与分子生物学
CiteScore
4.70
自引率
3.60%
发文量
139
审稿时长
2 months
期刊介绍: Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).
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