Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality.

IF 1.6 4区医学 Q4 BIOPHYSICS Biointerphases Pub Date : 2024-07-01 DOI:10.1116/6.0003685

Sadegh Ghorbani, Duncan S Sutherland

{"title":"Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality.","authors":"Sadegh Ghorbani, Duncan S Sutherland","doi":"10.1116/6.0003685","DOIUrl":null,"url":null,"abstract":"<p><p>A promising research direction in the field of biological engineering is the design and functional programming of three-dimensional (3D) biointerfaces designed to support living cell functionality and growth in vitro, offering a route to precisely regulate cellular behaviors and phenotypes for addressing therapeutic challenges. While traditional two-dimensional (2D) biointerfaces have provided valuable insights, incorporating specific signaling cues into a 3D biointeractive microenvironment at the right locations and time is now recognized as crucial for accurately programming cellular decision-making and communication processes. This approach aims to engineer cell-centric microenvironments with the potential to recapitulate complex biological functions into a finite set of growing cellular organizations. Additionally, they provide insights into the hierarchical logic governing the relationship between molecular components and higher-order multicellular functionality. The functional live cell-based microenvironment engineered through such innovative biointerfaces has the potential to be used as an in vitro model system for expanding our understanding of cellular behaviors or as a therapeutic habitat where cellular functions can be reprogrammed.</p>","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biointerphases","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1116/6.0003685","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOPHYSICS","Score":null,"Total":0}

引用次数: 0

Abstract

A promising research direction in the field of biological engineering is the design and functional programming of three-dimensional (3D) biointerfaces designed to support living cell functionality and growth in vitro, offering a route to precisely regulate cellular behaviors and phenotypes for addressing therapeutic challenges. While traditional two-dimensional (2D) biointerfaces have provided valuable insights, incorporating specific signaling cues into a 3D biointeractive microenvironment at the right locations and time is now recognized as crucial for accurately programming cellular decision-making and communication processes. This approach aims to engineer cell-centric microenvironments with the potential to recapitulate complex biological functions into a finite set of growing cellular organizations. Additionally, they provide insights into the hierarchical logic governing the relationship between molecular components and higher-order multicellular functionality. The functional live cell-based microenvironment engineered through such innovative biointerfaces has the potential to be used as an in vitro model system for expanding our understanding of cellular behaviors or as a therapeutic habitat where cellular functions can be reprogrammed.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

建设更好的栖息地：三维生物界面中的时空信号提示，实现量身定制的细胞功能。

生物工程领域一个前景广阔的研究方向是三维（3D）生物界面的设计和功能编程，旨在支持体外活细胞的功能和生长，提供了一条精确调节细胞行为和表型以应对治疗挑战的途径。虽然传统的二维（2D）生物界面提供了宝贵的见解，但在正确的位置和时间将特定的信号线索纳入三维生物交互微环境，现在已被公认为是精确编程细胞决策和交流过程的关键。这种方法旨在设计以细胞为中心的微环境，有可能将复杂的生物功能再现到一组有限的不断生长的细胞组织中。此外，它们还能让人们深入了解分子成分与高阶多细胞功能之间的分层逻辑关系。通过这种创新的生物界面设计出的基于活细胞的功能性微环境有可能被用作体外模型系统，以扩大我们对细胞行为的了解，或用作治疗栖息地，对细胞功能进行重新编程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Biointerphases 生物-材料科学：生物材料

自引率

0.00%

发文量

期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.