Internal dosimetry and biodistribution of indigenously prepared 177Lu-DOTA-rituximab in lymphoma and other hematological malignancies treated with rituximab.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-06-28 DOI:10.1097/MNM.0000000000001875
Yeshwanth Edamadaka, Rahul V Parghane, Sudeep Sahu, Sangita Lad, Kamaldeep, Gaurav Wanage, Chandrakala Shanmukhaiah, Vrinda Kulkarni, Sandip Basu
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Abstract

Objective: The aim of this study was to evaluate the biodistribution and dosimetry of lutetium-177-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (177Lu-DOTA)-rituximab in CD20+ non-Hodgkin's lymphoma and other hematological malignancies treated with rituximab.

Methods: The standard dosimetry protocol was used, with cold rituximab infusion, then a diagnostic activity of 177Lu-DOTA-rituximab. Planar images were acquired at multiple time points. Normal organs and tumor dosimetry were performed by using organ and tumor-specific regions of interest and whole-body counts were obtained serially after pixel matched, background, scatter, and attenuation correction. The mean radiation absorbed doses were obtained from OLINDA/EXM v2.1.1 and ORIGIN software.

Results: A total of 22 patients were included in this study. Prolonged blood pool clearance of 177Lu-DOTA-rituximab with long residence time in the blood pool and normal organs were observed. The whole body effective half-life was 104.5 ± 22 h. The mean total body radiation absorbed dose was 0.208 ± 0.03 mGy/MBq and the mean total body effective dose was 0.196 ± 0.05 mGy/MBq of 177Lu-DOTA-rituximab. The mean radiation absorbed doses of 0.613 ± 0.21, 1.68 ± 2, 1.01 ± 0.42, and 0.136 ± 0.02mGy/MBq were seen for the liver, spleen, kidneys, and bone marrow, respectively. Tumor lesion uptake was noticed in two patients with tumor radiation absorbed doses were 0.842 mGy/MBq in one and 9.9 mGy/MBq in the other patient. A strong correlation was obtained between the cumulative activities of radiation-absorbed doses derived from ORIGIN and OLINDA software methods at a significant P value less than 0.001.

Conclusion: The results of our study demonstrated favorable biodistribution and dosimetry of indigenously produced 177Lu-DOTA-rituximab in patients with CD20+ lymphoma. These results can be used for future studies of radioimmunotherapy employing 177Lu-DOTA-rituximab.

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自主制备的 177Lu-DOTA-rituximab 在接受利妥昔单抗治疗的淋巴瘤和其他血液恶性肿瘤中的内部剂量测定和生物分布。
研究目的本研究旨在评估镥-177-1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(177Lu-DOTA)-利妥昔单抗在接受利妥昔单抗治疗的CD20+非霍奇金淋巴瘤和其他血液恶性肿瘤中的生物分布和剂量测量:方法:采用标准剂量测定方案,冷注利妥昔单抗,然后进行177Lu-DOTA-利妥昔单抗诊断活动。在多个时间点采集平面图像。利用器官和肿瘤特异性感兴趣区进行正常器官和肿瘤剂量测定,并在像素匹配、背景、散射和衰减校正后连续获得全身计数。平均辐射吸收剂量由 OLINDA/EXM v2.1.1 和 ORIGIN 软件得出:本研究共纳入 22 名患者。观察到177Lu-DOTA-利妥昔单抗的血池清除时间较长,在血池和正常器官中的停留时间较长。全身有效半衰期为 104.5 ± 22 小时。177Lu-DOTA-rituximab 的平均全身辐射吸收剂量为 0.208 ± 0.03 mGy/MBq,平均全身有效剂量为 0.196 ± 0.05 mGy/MBq。肝脏、脾脏、肾脏和骨髓的平均辐射吸收剂量分别为 0.613 ± 0.21、1.68 ± 2、1.01 ± 0.42 和 0.136 ± 0.02mGy/MBq。有两名患者出现肿瘤病灶摄取,其中一名患者的肿瘤辐射吸收剂量为 0.842 mGy/MBq,另一名患者为 9.9 mGy/MBq。ORIGIN和OLINDA软件方法得出的辐射吸收剂量累积活性之间存在很强的相关性,P值小于0.001:我们的研究结果表明,自主生产的177Lu-DOTA-利妥昔单抗在CD20+淋巴瘤患者中具有良好的生物分布和剂量学效应。这些结果可用于今后使用 177Lu-DOTA-rituximab 进行放射免疫治疗的研究。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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