Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material.

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY Beilstein Journal of Nanotechnology Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.65
Veronika Pálos, Krisztina S Nagy, Rita Pázmány, Krisztina Juriga-Tóth, Bálint Budavári, Judit Domokos, Dóra Szabó, Ákos Zsembery, Angela Jedlovszky-Hajdu
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Abstract

In this research, we applied electrospinning to create a two-component biodegradable polymeric scaffold containing polysuccinimide (PSI) and antibacterial salts. Antibacterial agents for therapeutical purposes mostly contain silver ions which are associated with high environmental impact and, in some cases, may cause undesired immune reactions. In our work, we prepared nanofibrous systems containing antibacterial and tissue-regenerating salts of zinc acetate or strontium nitrate in different concentrations, whose structures may be suitable for developing biomedical wound dressing systems in the future. Several experiments have been conducted to optimize the physicochemical, mechanical, and biological properties of the scaffolds developed for application as wound dressings. The scaffold systems obtained by PSI synthesis, salt addition, and fiber formation were first investigated by scanning electron microscopy. In almost all cases, different salts caused a decrease in the fiber diameter of PSI polymer-based systems (<500 nm). Fourier-transform infrared spectroscopy was applied to verify the presence of salts in the scaffolds and to determine the interaction between the salt and the polymer. Another analysis, energy-dispersive X-ray spectroscopy, was carried out to determine strontium and zinc atoms in the scaffolds. Our result showed that the salts influence the mechanical properties of the polymer scaffold, both in terms of specific load capacity and relative elongation values. According to the dissolution experiments, the whole amount of strontium nitrate was dissolved from the scaffold in 8 h; however, only 50% of the zinc acetate was dissolved. In addition, antibacterial activity tests were performed with four different bacterial strains relevant to skin surface injuries, leading to the appearance of inhibition zones around the scaffold discs in most cases. We also investigated the potential cytotoxicity of the scaffolds on human tumorous and healthy cells. Except for the ones containing zinc acetate salt, the scaffolds are not cytotoxic to either tumor or healthy cells.

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含有不同盐类的电纺聚琥珀酰亚胺支架可作为潜在的伤口敷料。
在这项研究中,我们应用电纺丝技术制造了一种含有聚琥珀酰亚胺(PSI)和抗菌盐的双组分可生物降解聚合物支架。用于治疗目的的抗菌剂大多含有银离子,而银离子对环境的影响很大,在某些情况下还可能引起不良的免疫反应。在我们的工作中,我们制备了含有不同浓度的醋酸锌或硝酸锶抗菌盐和组织再生盐的纳米纤维系统,其结构可能适用于未来生物医学伤口敷料系统的开发。为了优化所开发的支架的物理化学、机械和生物特性,我们进行了多项实验,以便将其应用于伤口敷料。首先用扫描电子显微镜研究了通过 PSI 合成、加盐和纤维形成获得的支架系统。几乎在所有情况下,不同的盐分都会导致 PSI 聚合物体系的纤维直径减小 (
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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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