João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis
{"title":"Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation.","authors":"João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis","doi":"10.1080/17460913.2024.2366630","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To develop a β-AgVO<sub>3</sub> gel and evaluate its physicochemical stability and antifungal activity against <i>Candida albicans</i>. <b>Materials & methods:</b> The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO<sub>3</sub>. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion. <b>Results:</b> The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO<sub>3</sub> concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO<sub>3</sub> gel with 20xMIC. <b>Conclusion:</b> The β-AgVO<sub>3</sub> gel showed physicochemical stability and antifungal activity.</p>","PeriodicalId":12773,"journal":{"name":"Future microbiology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/17460913.2024.2366630","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans. Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion. Results: The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC. Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
