The pros and confs of IL-18 activation

IF 25.5 1区 医学 Q1 IMMUNOLOGY Immunity Pub Date : 2024-07-09 DOI:10.1016/j.immuni.2024.06.006
Danielle M. Clancy, Julie Andries, Savvas N. Savvides
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引用次数: 0

Abstract

Interleukin-1 (IL-1) family cytokines are key immunological regulators that achieve their signaling prowess after post-translational proteolytic processing. In this issue of Immunity, Dong et al. reveal the structural consequences of this process on proinflammatory IL-18, demonstrating that pro-IL-18 and mature IL-18 are structurally distinct.

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IL-18 激活的利弊
白细胞介素-1(IL-1)家族细胞因子是关键的免疫调控因子,它们在经过翻译后蛋白水解加工后才具有信号能力。在本期《免疫》杂志上,Dong 等人揭示了这一过程对原炎性 IL-18 的结构影响,证明原 IL-18 和成熟 IL-18 在结构上是不同的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunity
Immunity 医学-免疫学
CiteScore
49.40
自引率
2.20%
发文量
205
审稿时长
6 months
期刊介绍: Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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