Dermatophytosis Caused by Trichophyton indotineae (Trichophyton mentagrophytes ITS Genotype VIII) in Sri Lanka.

IF 1.9 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH American Journal of Tropical Medicine and Hygiene Pub Date : 2024-07-09 Print Date: 2024-09-04 DOI:10.4269/ajtmh.24-0027

Nayani P Madarasingha, Harshini Thabrew, Silk Uhrlass, Surammika Eriyagama, Dieter Reinal, Primali I Jayasekera, Pietro Nenoff

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Abstract

Over the past few years, a recalcitrant dermatophytosis has been observed on the Indian subcontinent, including Sri Lanka, which has caused a major public health issue in the region. An emerging species, Trichophyton indotineae, first described as Trichophyton mentagrophytes ITS genotype VIII, is thought to be responsible for this fast-spreading, mostly terbinafine-resistant dermatophytosis. Recalcitrant dermatophytosis is a challenge to dermatologists, and knowing the causative species and antifungal sensitivity in the earlier stage of management would be invaluable. We report a case series of patients with dermatophytosis caused by T. indotineae in Sri Lanka. This is the first detection of this highly terbinafine-resistant strain in Sri Lanka, and existence of this species should be taken seriously by dermatologists and healthcare policymakers for better management of tinea infections and antifungal stewardship in the country.

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斯里兰卡 indotineae 毛癣菌引起的皮肤癣菌病（门冬癣毛癣菌 ITS 基因型 VIII）。

在过去几年中，包括斯里兰卡在内的印度次大陆出现了一种顽固的皮癣，给该地区带来了严重的公共卫生问题。一种新出现的物种--吲哚癣毛癣菌（Trichophyton indotineae），最初被描述为萌芽癣毛癣菌（Trichophyton mentagrophytes ITS genotype VIII），被认为是造成这种快速传播、主要对特比萘芬耐药的皮癣病的罪魁祸首。顽固性皮癣对皮肤科医生来说是一项挑战，在治疗的早期阶段了解致病菌的种类和抗真菌药物的敏感性将非常有价值。我们报告了斯里兰卡由 T. indotineae 引起的皮癣患者的一系列病例。这是斯里兰卡首次发现这种对特比萘芬高度耐药的菌株，皮肤科医生和医疗政策制定者应认真对待这种菌株的存在，以便更好地管理该国的皮癣感染和抗真菌药物管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries