Association of body composition indicators with colorectal cancer: a hospital-based case-control study.

IF 2.7 3区医学 Q3 ONCOLOGY Journal of Cancer Research and Clinical Oncology Pub Date : 2024-07-09 DOI:10.1007/s00432-024-05866-4

Qiujin Chen, Kai Li, Yang Liu, Xiaozhai Yu, Fengrong Ou

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Abstract

Purpose: Colorectal cancer (CRC) is a common malignancy that affects adults worldwide, causing a high disease burden. Few studies have examined the relationship between body composition (BC) measures and the prevalence of CRC. Our purpose was to investigate the relationship between pertinent BC indicators and CRC.

Methods: Bioelectrical impedance analysis, laboratory test results, face-to-face questionnaire investigation, and nutritional risk assessment (Nutritional Risk Screening 2002 and Patient-Generated Subjective Global Assessment) were used in this case-control study. Bioelectrical impedance analysis in the case group was performed prior to antitumor therapy/surgery.

Results: From June 2018 to January 2019, a total of 303 cases and 286 controls were included. The results showed that low body fat percentage (BFP) and high visceral adiposity index (VAI) groups had a higher risk of developing CRC in comparison to the normal BFP and normal VAI groups. The risk of CRC decreased with the increase of BFP. The group with a normal BC had a lower risk of developing CRC compared to those with a greater VAI and a lower BFP, as indicated by the results of the pairwise and total combinations of VAI, fat-free mass index (FFMI), and BFP. Additionally, FFMI and VAI had positive correlations with prealbumin, serum albumin, and nutritional risk scores.

Conclusion: Low BFP and high VAI are associated with higher CRC risk. FFMI and VAI are positively correlated with prealbumin, serum albumin, and nutritional risk scores in CRC patients.

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身体成分指标与结直肠癌的关系：一项基于医院的病例对照研究。

目的：结直肠癌（CRC）是一种常见的恶性肿瘤，影响着全世界的成年人，造成了沉重的疾病负担。很少有研究探讨身体成分（BC）指标与 CRC 发病率之间的关系。我们的目的是调查相关的 BC 指标与 CRC 之间的关系：这项病例对照研究采用了生物电阻抗分析、实验室检测结果、面对面问卷调查和营养风险评估（2002 年营养风险筛查和患者自发主观全面评估）。病例组的生物电阻抗分析在抗肿瘤治疗/手术前进行：2018年6月至2019年1月，共纳入303例病例和286例对照。结果显示，与正常体脂率（BFP）和正常内脏脂肪指数（VAI）组相比，低体脂率（BFP）和高内脏脂肪指数（VAI）组患 CRC 的风险更高。随着 BFP 的增加，患 CRC 的风险降低。VAI、去脂质量指数（FFMI）和BFP的成对组合和总组合结果表明，与VAI较高和BFP较低的人群相比，BC正常的人群患上CRC的风险较低。此外，FFMI 和 VAI 与前白蛋白、血清白蛋白和营养风险评分呈正相关：结论：低 BFP 和高 VAI 与较高的 CRC 风险相关。结论：低 BFP 和高 VAI 与较高的 CRC 风险有关，FFMI 和 VAI 与 CRC 患者的前白蛋白、血清白蛋白和营养风险评分呈正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cancer Research and Clinical Oncology 医学-肿瘤学

CiteScore

4.00

自引率

2.80%

发文量

577

审稿时长

2 months

期刊介绍： The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.