Clinical efficacy of Baijin pills in the treatment of generalized tonic-clonic seizure epilepsy with cognitive impairment.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-06-19 DOI:10.5498/wjp.v14.i6.938

Jing-Bo Li, Jing Jiang, Lian Xue, Shuai Zhao, Hong-Quan Liu

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Abstract

Background: The generalized tonic-clonic seizure (GTCS) is the most usual variety of epileptic seizure. It is mainly characterized by strong body muscle rigidity, loss of consciousness, a disorder of plant neurofunction, and significant damage to cognitive function. The effect of antiepileptic drugs on cognition should also be considered. At present, there is no effective treatment for patients with epilepsy, but traditional Chinese medicine has shown a significant effect on chronic disease with fewer harmful side effects and should, therefore, be considered for the therapy means of epilepsy with cognitive dysfunction.

Aim: To investigate the clinical efficacy of Baijin pills for treating GTCS patients with cognitive impairment.

Methods: This prospective study enrolled patients diagnosed with GTCS between January 2020 and December 2023 and separate them into two groups (experimental and control) using random number table method. The control group was treated with sodium valproate, and the experimental group was Baijin pills and sodium valproate for three months. The frequency and duration of each seizure, the Montreal Cognitive Assessment Scale (MoCA), and the Quality of Life Rating Scale (QOLIE-31) were recorded before and after treatment.

Results: There were 85 patients included (42 in the control group and 43 in the experimental group). After treatment, the seizure frequency in the experimental group was significantly reduced (P < 0.05), and seizure duration was shortened (P < 0.01). The total MoCA score in the experimental group significantly increased compared to before treatment (P < 0.01), and the sub-item scores, except naming and abstract generalization ability, significantly increased (P < 0.05), whereas the total MoCA score in the control group significantly decreased after treatment (P < 0.05). The QOLIE-31 score of the experimental group increased significantly after treatment compared to before treatment (P < 0.01).

Conclusion: Baijin pills have a good clinical effect on epilepsy with cognitive dysfunction.

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白金丸治疗伴有认知障碍的全身强直-阵挛发作性癫痫的临床疗效。

背景：全身强直-阵挛发作（GTCS）是癫痫发作中最常见的一种。它的主要特征是全身肌肉强直、意识丧失、植物神经功能紊乱、认知功能严重受损。抗癫痫药物对认知功能的影响也应考虑在内。目前，癫痫患者尚无有效的治疗方法，而中药对慢性病有显著疗效，且毒副作用较小，因此，应考虑作为癫痫伴认知功能障碍的治疗手段。目的：探讨白金丸治疗伴认知功能障碍的GTCS患者的临床疗效：本前瞻性研究选取2020年1月至2023年12月期间确诊的GTCS患者，采用随机数字表法将其分为两组（实验组和对照组）。对照组使用丙戊酸钠治疗，实验组使用白金丸和丙戊酸钠治疗三个月。记录治疗前后每次发作的频率和持续时间、蒙特利尔认知评估量表（MoCA）和生活质量评分量表（QOLIE-31）：共纳入 85 名患者（对照组 42 人，实验组 43 人）。治疗后，实验组癫痫发作频率明显减少（P < 0.05），发作持续时间缩短（P < 0.01）。实验组的 MoCA 总分与治疗前相比明显提高（P < 0.01），除命名和抽象概括能力外，其他分项得分均明显提高（P < 0.05），而对照组的 MoCA 总分在治疗后明显下降（P < 0.05）。实验组的QOLIE-31评分在治疗后明显高于治疗前（P < 0.01）：结论：白金丸对伴有认知功能障碍的癫痫有较好的临床疗效。

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