Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

IF 7.9 1区 医学 Q1 CLINICAL NEUROLOGY Alzheimer's Research & Therapy Pub Date : 2024-07-10 DOI:10.1186/s13195-024-01514-8
Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi
{"title":"Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population","authors":"Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi","doi":"10.1186/s13195-024-01514-8","DOIUrl":null,"url":null,"abstract":"<p><b>Correction: Alz Res Therapy 16, 45 (2024)</b></p><p><b>https://doi.org/10.1186/s13195-024-01414-x</b></p><br/><p>Following publication of the original article [1], the authors corrected an error in Fig. 2.</p><figure><figcaption><b data-test=\"figure-caption-text\">Fig. 2</b></figcaption><picture><source srcset=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13195-024-01514-8/MediaObjects/13195_2024_1514_Fig1_HTML.png?as=webp\" type=\"image/webp\"/><img alt=\"figure 1\" aria-describedby=\"Fig1\" height=\"730\" loading=\"lazy\" src=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13195-024-01514-8/MediaObjects/13195_2024_1514_Fig1_HTML.png\" width=\"685\"/></picture><p>The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (<b>A</b>, <b>C</b>) and pTau/Aβ42 (<b>B</b>, <b>D</b>) ratios by decile of PRS are shown in each diagnostic group. The participants were divided into ten groups based on the PRS.noAPOE, ranging from the lowest group (1st decile) to the highest group (10th decile). CN = cognitively normal; MCI = mild cognitive impairment; ADD = Alzheimer’s disease dementia</p><span>Full size image</span><svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-chevron-right-small\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></figure><p><b>Error:</b> Figs. 2C and D are the same figures as Figs. 2A and B in the published article.</p><p>The corrected figure is given below:</p><p>The original article [1] has been updated.</p><ol data-track-component=\"outbound reference\" data-track-context=\"references section\"><li data-counter=\"1.\"><p>Kikuchi M, Miyashita A, Hara N, et al. Polygenic effects on the risk of Alzheimer’s disease in the Japanese population. Alz Res Therapy. 2024;16:45. https://doi.org/10.1186/s13195-024-01414-x.</p><p>Article CAS Google Scholar </p></li></ol><p>Download references<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><h3>Authors and Affiliations</h3><ol><li><p>Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, 6‑2‑3 Kashiwanoha, Kashiwa, Chiba, 277‑0882, Japan</p><p>Masataka Kikuchi &amp; Akihiro Nakaya</p></li><li><p>Department of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan</p><p>Masataka Kikuchi</p></li><li><p>Department of Molecular Genetics, Brain Research Institute, Niigata University, 1‑757 Asahimachi, Niigata, 951‑8585, Japan</p><p>Akinori Miyashita, Norikazu Hara, Kensaku Kasuga &amp; Takeshi Ikeuchi</p></li><li><p>Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan</p><p>Yuko Saito &amp; Shigeo Murayama</p></li><li><p>Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Osaka, Japan</p><p>Shigeo Murayama</p></li><li><p>Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan</p><p>Akiyoshi Kakita</p></li><li><p>Department of General Medicine &amp; General Internal Medicine, Nagoya City University Graduate School of Medicine, Nagoya, Japan</p><p>Hiroyasu Akatsu</p></li><li><p>Medical Genome Center, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan</p><p>Kouichi Ozaki</p></li><li><p>RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan</p><p>Kouichi Ozaki</p></li><li><p>Core Facility Administration, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan</p><p>Shumpei Niida</p></li><li><p>Social Welfare Corporation Asahigawaso, Asahigawaso Research Institute, Okayama, Japan</p><p>Ryozo Kuwano</p></li><li><p>Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</p><p>Takeshi Iwatsubo</p></li></ol><span>Authors</span><ol><li><span>Masataka Kikuchi</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Akinori Miyashita</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Norikazu Hara</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Kensaku Kasuga</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Yuko Saito</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Shigeo Murayama</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Akiyoshi Kakita</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Hiroyasu Akatsu</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Kouichi Ozaki</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Shumpei Niida</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Ryozo Kuwano</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Takeshi Iwatsubo</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Akihiro Nakaya</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li><li><span>Takeshi Ikeuchi</span>View author publications<p>You can also search for this author in <span>PubMed<span> </span>Google Scholar</span></p></li></ol><h3>Consortia</h3><h3>the Alzheimer’s Disease Neuroimaging Initiative</h3><ul><li>Michael W. Weiner</li><li>, Sara S. Mason</li><li>, Colleen S. Albers</li><li>, David Knopman</li><li>, Kris Johnson</li><li>, Paul Aisen</li><li>, Ronald Petersen</li><li>, Clifford R. Jack</li><li>, William Jagust</li><li>, John Q. Trojanowki</li><li>, Arthur W. Toga</li><li>, Lon S. Schneider</li><li>, Sonia Pawluczyk</li><li>, Mauricio Beccera</li><li>, Liberty Teodoro</li><li>, Bryan M. Spann</li><li>, Laurel Beckett</li><li>, Robert C. Green</li><li>, John Morris</li><li>, Leslie M. Shaw</li><li>, Beau Ances</li><li>, John C. Morris</li><li>, Maria Carroll</li><li>, Mary L. Creech</li><li>, Erin Franklin</li><li>, Mark A. Mintun</li><li>, Stacy Schneider</li><li>, Angela Oliver</li><li>, Jeffrey Kaye</li><li>, Joseph Quinn</li><li>, Lisa Silbert</li><li>, Betty Lind</li><li>, Raina Carter</li><li>, Sara Dolen</li><li>, James Brewer</li><li>, Helen Vanderswag</li><li>, Adam Fleisher</li><li>, Judith L. Heidebrink</li><li>, Joanne L. Lord</li><li>, Rachelle S. Doody</li><li>, Javier Villanueva-Meyer</li><li>, Munir Chowdhury</li><li>, Susan Rountree</li><li>, Mimi Dang</li><li>, Yaakov Stern</li><li>, Lawrence S. Honig</li><li>, Karen L. Bell</li><li>, Daniel Marson</li><li>, Randall Griffith</li><li>, David Clark</li><li>, David Geldmacher</li><li>, John Brockington</li><li>, Erik Roberson</li><li>, Marissa Natelson Love</li><li>, Hillel Grossman</li><li>, Effie Mitsis</li><li>, Raj C. Shah</li><li>, Leyla deToledo-Morrell</li><li>, Ranjan Duara</li><li>, Daniel Varon</li><li>, Maria T. Greig</li><li>, Peggy Roberts</li><li>, Marilyn Albert</li><li>, Chiadi Onyike</li><li>, Daniel D’Agostino</li><li>, Stephanie Kielb</li><li>, James E. Galvin</li><li>, Brittany Cerbone</li><li>, Christina A. Michel</li><li>, Dana M. Pogorelec</li><li>, Henry Rusinek</li><li>, Mony J. de Leon</li><li>, Lidia Glodzik</li><li>, Susan De Santi</li><li>, P. Murali Doraiswamy</li><li>, Jeffrey R. Petrella</li><li>, Salvador Borges-Neto</li><li>, Terence Z. Wong</li><li>, Edward Coleman</li><li>, Charles D. Smith</li><li>, Greg Jicha</li><li>, Peter Hardy</li><li>, Partha Sinha</li><li>, Elizabeth Oates</li><li>, Gary Conrad</li><li>, Anton P. Porsteinsson</li><li>, Bonnie S. Goldstein</li><li>, Kim Martin</li><li>, Kelly M. Makino</li><li>, M. Saleem Ismail</li><li>, Connie Brand</li><li>, Ruth A. Mulnard</li><li>, Gaby Thai</li><li>, Catherine Mc-Adams-Ortiz</li><li>, Kyle Womack</li><li>, Dana Mathews</li><li>, Mary Quiceno</li><li>, Allan I. Levey</li><li>, James J. Lah</li><li>, Janet S. Cellar</li><li>, Jeffrey M. Burns</li><li>, Russell H. Swerdlow</li><li>, William M. Brooks</li><li>, Liana Apostolova</li><li>, Martin R. Farlow</li><li>, Ann Marie Hake</li><li>, Brandy R. Matthews</li><li>, Jared R. Brosch</li><li>, Scott Herring</li><li>, Cynthia Hunt</li><li>, Kathleen Tingus</li><li>, Ellen Woo</li><li>, Daniel H. S. Silverman</li><li>, Po H. Lu</li><li>, George Bartzokis</li><li>, Neill R. Graff-Radford</li><li>, Francine Parfitt</li><li>, Tracy Kendall</li><li>, Heather Johnson</li><li>, Christopher H. van Dyck</li><li>, Richard E. Carson</li><li>, Martha G. MacAvoy</li><li>, Pradeep Varma</li><li>, Howard Chertkow</li><li>, Howard Bergman</li><li>, Chris Hosein</li><li>, Sandra Black</li><li>, Bojana Stefanovic</li><li>, Curtis Caldwell</li><li>, Ging-Yuek Robin Hsiung</li><li>, Howard Feldman</li><li>, Benita Mudge</li><li>, Michele Assaly</li><li>, Elizabeth Finger</li><li>, Stephen Pasternack</li><li>, Irina Rachisky</li><li>, Dick Trost</li><li>, Andrew Kertesz</li><li>, Charles Bernick</li><li>, Donna Munic</li><li>, Marek Marsel Mesulam</li><li>, Kristine Lipowski</li><li>, Sandra Weintraub</li><li>, Borna Bonakdarpour</li><li>, Diana Kerwin</li><li>, Chuang-Kuo Wu</li><li>, Nancy Johnson</li><li>, Carl Sadowsky</li><li>, Teresa Villena</li><li>, Raymond Scott Turner</li><li>, Kathleen Johnson</li><li>, Brigid Reynolds</li><li>, Reisa A. Sperling</li><li>, Keith A. Johnson</li><li>, Gad Marshall</li><li>, Jerome Yesavage</li><li>, Joy L. Taylor</li><li>, Barton Lane</li><li>, Allyson Rosen</li><li>, Jared Tinklenberg</li><li>, Marwan N. Sabbagh</li><li>, Christine M. Belden</li><li>, Sandra A. Jacobson</li><li>, Sherye A. Sirrel</li><li>, Neil Kowall</li><li>, Ronald Killiany</li><li>, Andrew E. Budson</li><li>, Alexander Norbash</li><li>, Patricia Lynn Johnson</li><li>, Thomas O. Obisesan</li><li>, Saba Wolday</li><li>, Joanne Allard</li><li>, Alan Lerner</li><li>, Paula Ogrocki</li><li>, Curtis Tatsuoka</li><li>, Parianne Fatica</li><li>, Evan Fletcher</li><li>, Pauline Maillard</li><li>, John Olichney</li><li>, Charles DeCarli</li><li>, Owen Carmichael</li><li>, Smita Kittur</li><li>, Michael Borrie</li><li>, T.-Y. Lee</li><li>, Rob Bartha</li><li>, Sterling Johnson</li><li>, Sanjay Asthana</li><li>, Cynthia M. Carlsson</li><li>, Steven G. Potkin</li><li>, Adrian Preda</li><li>, Dana Nguyen</li><li>, Pierre Tariot</li><li>, Anna Burke</li><li>, Nadira Trncic</li><li>, Stephanie Reeder</li><li>, Vernice Bates</li><li>, Horacio Capote</li><li>, Michelle Rainka</li><li>, Douglas W. Scharre</li><li>, Maria Kataki</li><li>, Anahita Adeli</li><li>, Earl A. Zimmerman</li><li>, Dzintra Celmins</li><li>, Alice D. Brown</li><li>, Godfrey D. Pearlson</li><li>, Karen Blank</li><li>, Karen Anderson</li><li>, Laura A. Flashman</li><li>, Marc Seltzer</li><li>, Mary L. Hynes</li><li>, Robert B. Santulli</li><li>, Kaycee M. Sink</li><li>, Leslie Gordineer</li><li>, Jeff D. Williamson</li><li>, Pradeep Garg</li><li>, Franklin Watkins</li><li>, Brian R. Ott</li><li>, Henry Querfurth</li><li>, Geoffrey Tremont</li><li>, Stephen Salloway</li><li>, Paul Malloy</li><li>, Stephen Correia</li><li>, Howard J. Rosen</li><li>, Bruce L. Miller</li><li>, David Perry</li><li>, Jacobo Mintzer</li><li>, Kenneth Spicer</li><li>, David Bachman</li><li>, Nunzio Pomara</li><li>, Raymundo Hernando</li><li>, Antero Sarrael</li><li>, Norman Relkin</li><li>, Gloria Chaing</li><li>, Michael Lin</li><li>, Lisa Ravdin</li><li>, Amanda Smith</li><li>, Balebail Ashok Raj</li><li> &amp; Kristin Fargher</li></ul><h3>the Japanese Alzheimer’s Disease Neuroimaging Initiative</h3><ul><li>Takeshi Iwatsubo</li><li>, Takashi Asada</li><li>, Hiroyuki Arai</li><li>, Morihiro Sugishita</li><li>, Hiroshi Matsuda</li><li>, Noriko Sato</li><li>, Hajime Sato</li><li>, Kengo Ito</li><li>, Teruhiko Kachi</li><li>, Kenji Toba</li><li>, Michio Senda</li><li>, Kenji Ishii</li><li>, Ryozo Kuwano</li><li>, Takeshi Ikeuchi</li><li>, Shun Shimohama</li><li>, Masaki Saitoh</li><li>, Rika Yamauchi</li><li>, Takashi Hayashi</li><li>, Chiyoko Takanami</li><li>, Seiju Kobayashi</li><li>, Norihito Nakano</li><li>, Junichiro Kanazawa</li><li>, Takeshi Ando</li><li>, Masato Hareyama</li><li>, Masamitsu Hatakenaka</li><li>, Eriko Tsukamoto</li><li>, Shinji Ochi</li><li>, Mikio Shoji</li><li>, Etsuro Matsubara</li><li>, Takeshi Kawarabayashi</li><li>, Yasuhito Wakasaya</li><li>, Takashi Nakata</li><li>, Naoko Nakahata</li><li>, Shuichi Ono</li><li>, Yoshihiro Takai</li><li>, Satoshi Takahashi</li><li>, Hisashi Yonezawa</li><li>, Junko Takahashi</li><li>, Masako Kudoh</li><li>, Kuniko Ueno</li><li>, Hiromi Sakashita</li><li>, Kuniko Watanabe</li><li>, Makoto Sasaki</li><li>, Yutaka Matsumura</li><li>, Yohsuke Hirata</li><li>, Tsuyoshi Metoki</li><li>, Susumu Hayakawa</li><li>, Yuichi Sato</li><li>, Masayuki Takeda</li><li>, Koichiro Sera</li><li>, Kazunori Terasaki</li><li>, Toshiaki Sasaki</li><li>, Yoshihiro Saitoh</li><li>, Shoko Goto</li><li>, Ken Nagata</li><li>, Tetsuya Maeda</li><li>, Yasushi Kondoh</li><li>, Takashi Yamazaki</li><li>, Daiki Takano</li><li>, Mio Miyata</li><li>, Hiromi Komatsu</li><li>, Mayumi Watanabe</li><li>, Tomomi Sinoda</li><li>, Rena Muraoka</li><li>, Kayoko Kikuchi</li><li>, Hitomi Ito</li><li>, Aki Sato</li><li>, Toshibumi Kinoshita</li><li>, Hideyo Toyoshima</li><li>, Kaoru Sato</li><li>, Shigeki Sugawara</li><li>, Isao Ito</li><li>, Fumiko Kumagai</li><li>, Katsutoshi Furukawa</li><li>, Masaaki Waragai</li><li>, Naoki Tomita</li><li>, Mari Ootsuki</li><li>, Katsumi Sugawara</li><li>, Satomi Sugawara</li><li>, Nobuyuki Okamura</li><li>, Shunji Mugikura</li><li>, Atsushi Umetsu</li><li>, Takanori Murata</li><li>, Tatsuo Nagasaka</li><li>, Yukitsuka Kudo</li><li>, Manabu Tashiro</li><li>, Shoichi Watanuki</li><li>, Masatoyo Nishizawa</li><li>, Takayoshi Tokutake</li><li>, Saeri Ishikawa</li><li>, Emiko Kishida</li><li>, Nozomi Sato</li><li>, Mieko Hagiwara</li><li>, Kumi Yamanaka</li><li>, Takeyuki Watanabe</li><li>, Taeko Takasugi</li><li>, Shoichi Inagawa</li><li>, Kenichi Naito</li><li>, Masanori Awaji</li><li>, Tsutomu Kanazawa</li><li>, Kouiti Okamoto</li><li>, Masaki Ikeda</li><li>, Yuiti Tasiro</li><li>, Syunn Nagamine</li><li>, Sathiko Kurose</li><li>, Tsuneo Yamazaki</li><li>, Shiori Katsuyama</li><li>, Sayuri Fukushima</li><li>, Etsuko Koya</li><li>, Makoto Amanuma</li><li>, Kouiti Ujita</li><li>, Kazuhiro Kishi</li><li>, Kazuhisa Tuda</li><li>, Noboru Oriuti</li><li>, Katsuyoshi Mizukami</li><li>, Tetsuaki Arai</li><li>, Etsuko Nakajima</li><li>, Katsumi Miyamoto</li><li>, Tomoya Kobayashi</li><li>, Saori Itoya</li><li>, Jun Ookubo</li><li>, Toshiya Akatsu</li><li>, Yoshiko Anzai</li><li>, Junya Ikegaki</li><li>, Yuuichi Katou</li><li>, Kaori Kimura</li><li>, Hajime Saitou</li><li>, Kazuya Shinoda</li><li>, Satoka Someya</li><li>, Hiroko Taguchi</li><li>, Kazuya Tashiro</li><li>, Masaya Tanaka</li><li>, Tatsuya Nemoto</li><li>, Ryou Wakabayashi</li><li>, Daisuke Watanabe</li><li>, Kousaku Saotome</li><li>, Ryou Kuchii</li><li>, Harumasa Takano</li><li>, Tetsuya Suhara</li><li>, Hitoshi Shinoto</li><li>, Hitoshi Shimada</li><li>, Makoto Higuchi</li><li>, Takaaki Mori</li><li>, Hiroshi Ito</li><li>, Takayuki Obata</li><li>, Yoshiko Fukushima</li><li>, Kazuko Suzuki</li><li>, Izumi Izumida</li><li>, Katsuyuki Tanimoto</li><li>, Takahiro Shiraishi</li><li>, Hitoshi Shinotoh</li><li>, Junko Shiba</li><li>, Hiroaki Yano</li><li>, Miki Satake</li><li>, Aimi Nakui</li><li>, Yae Ebihara</li><li>, Tomomi Hasegawa</li><li>, Yasumasa Yoshiyama</li><li>, Mami Kato</li><li>, Yuki Ogata</li><li>, Hiroyuki Fujikawa</li><li>, Nobuo Araki</li><li>, Yoshihiko Nakazato</li><li>, Takahiro Sasaki</li><li>, Tomokazu Shimadu</li><li>, Kimiko Yoshimaru</li><li>, Etsuko Imabayashi</li><li>, Asako Yasuda</li><li>, Keiko Ozawa</li><li>, Etuko Yamamoto</li><li>, Natsumi Nakamata</li><li>, Noriko Miyauchi</li><li>, Rieko Hashimoto</li><li>, Taishi Unezawa</li><li>, Takafumi Ichikawa</li><li>, Hiroki Hayashi</li><li>, Masakazu Yamagishi</li><li>, Tunemichi Mihara</li><li>, Masaya Hirano</li><li>, Shinichi Watanabe</li><li>, Junichiro Fukuhara</li><li>, Hajime Matsudo</li><li>, Nobuyuki Saito</li><li>, Atsushi Iwata</li><li>, Hisatomo Kowa</li><li>, Toshihiro Hayashi</li><li>, Ryoko Ihara</li><li>, Toji Miyagawa</li><li>, Mizuho Yoshida</li><li>, Yuri Koide</li><li>, Eriko Samura</li><li>, Kurumi Fujii</li><li>, Kaori Watanabe</li><li>, Nagae Orihara</li><li>, Toshimitsu Momose</li><li>, Miwako Takahashi</li><li>, Takuya Arai</li><li>, Yoshiki Kojima</li><li>, Akira Kunimatsu</li><li>, Harushi Mori</li><li>, Masami Goto</li><li>, Takeo Sarashina</li><li>, Syuichi Uzuki</li><li>, Seiji Katou</li><li>, Yoshiharu Sekine</li><li>, Yukihiro Takauchi</li><li>, Chiine Kagami</li><li>, Kazutomi Kanemaru</li><li>, Yasushi Nishina</li><li>, Maria Sakaibara</li><li>, Yumiko Okazaki</li><li>, Rieko Okada</li><li>, Maki Obata</li><li>, Shigeo Murayama</li><li>, Masaki Takao</li><li>, Yuko Iwata</li><li>, Mizuho Minami</li><li>, Yasuko Hanabusa</li><li>, Hanae Shingyouji</li><li>, Kyoko Tottori</li><li>, Aya Tokumaru</li><li>, Makoto Ichinose</li><li>, Kazuya Kume</li><li>, Syunsuke Kahashi</li><li>, Kunimasa Arima</li><li>, Shin Tanaka</li><li>, Yuko Nagahusa</li><li>, Masuhiro Sakata</li><li>, Mitsutoshi Okazaki</li><li>, Yuko Saito</li><li>, Maki Yamada</li><li>, Tadashi Tukamoto</li><li>, Tiine Kodama</li><li>, Tomoko Takeuchi</li><li>, Keiichiro Ozawa</li><li>, Yoshiko Kawaji</li><li>, Kyouko Tottori</li><li>, Yasuhiro Nakata</li><li>, Satoshi Sawada</li><li>, Makoto Mimatsu</li><li>, Daisuke Nakkamura</li><li>, Takeshi Tamaru</li><li>, Shunichirou Horiuchi</li><li>, Heii Arai</li><li>, Tsuneyoshi Ota</li><li>, Aiko Kodaka</li><li>, Yuko Tagata</li><li>, Tomoko Nakada</li><li>, Eizo Iseki</li><li>, Kiyoshi Sato</li><li>, Hiroshige Fujishiro</li><li>, Norio Murayama</li><li>, Masaru Suzuki</li><li>, Satoshi Kimura</li><li>, Masanobu Takahashi</li><li>, Haruo Hanyu</li><li>, Hirofumi Sakurai</li><li>, Takahiko Umahara</li><li>, Hidekazu Kanetaka</li><li>, Kaori Arashino</li><li>, Mikako Murakami</li><li>, Ai Kito</li><li>, Seiko Miyagi</li><li>, Kaori Doi</li><li>, Kazuyoshi Sasaki</li><li>, Mineo Yamazaki</li><li>, Akiko Ishiwata</li><li>, Yasushi Arai</li><li>, Akane Nogami</li><li>, Sumiko Fukuda</li><li>, Koichi Kozaki</li><li>, Yukiko Yamada</li><li>, Sayaka Kimura</li><li>, Ayako Machida</li><li>, Kuninori Kobayashi</li><li>, Hidehiro Mizusawa</li><li>, Nobuo Sanjo</li><li>, Mutsufusa Watanabe</li><li>, Takuya Ohkubo</li><li>, Hiromi Utashiro</li><li>, Yukiko Matsumoto</li><li>, Kumiko Hagiya</li><li>, Yoshiko Miyama</li><li>, Hitoshi Shibuya</li><li>, Isamu Ohashi</li><li>, Akira Toriihara</li><li>, Takako Shinozaki</li><li>, Haruko Hiraki</li><li>, Shinichi Ohtani</li><li>, Toshifumi Matsui</li><li>, Tomomi Toyama</li><li>, Hideki Sakurai</li><li>, Kumiko Sugiura</li><li>, Yu Hayasaka</li><li>, Hirofumi Taguchi</li><li>, Shizuo Hatashita</li><li>, Akari Imuta</li><li>, Akiko Matsudo</li><li>, Daichi Wakebe</li><li>, Hideki Hayakawa</li><li>, Mitsuhiro Ono</li><li>, Takayoshi Ohara</li><li>, Yukihiko Washimi</li><li>, Yutaka Arahata</li><li>, Akinori Takeda</li><li>, Akiko Yamaoka</li><li>, Masashi Tsujimoto</li><li>, Takiko Kawai</li><li>, Ai Honda</li><li>, Yoko Konagaya</li><li>, Hideyuki Hattori</li><li>, Kenji Yoshiyama</li><li>, Rina Miura</li><li>, Takashi Sakurai</li><li>, Miura Hisayuki</li><li>, Hidetoshi Endou</li><li>, Syousuke Satake</li><li>, Young Jae Hong</li><li>, Katsunari Iwai</li><li>, Masaki Suenaga</li><li>, Sumiko Morita</li><li>, Kengo Itou</li><li>, Takashi Kato</li><li>, Ken Fujiwara</li><li>, Rikio Katou</li><li>, Mariko Koyama</li><li>, Naohiko Fukaya</li><li>, Akira Tsuji</li><li>, Hitomi Shimizu</li><li>, Hiroyuki Fujisawa</li><li>, Tomoko Nakazawa</li><li>, Satoshi Koyama</li><li>, Takanori Sakata</li><li>, Masahito Yamada</li><li>, Mitsuhiro Yoshita</li><li>, Miharu Samuraki</li><li>, Kenjiro Ono</li><li>, Moeko Shinohara</li><li>, Yuki Soshi</li><li>, Kozue Niwa</li><li>, Chiaki Doumoto</li><li>, Mariko Hata</li><li>, Miyuki Matsushita</li><li>, Mai Tsukiyama</li><li>, Nozomi Takeda</li><li>, Sachiko Yonezawa</li><li>, Ichiro Matsunari</li><li>, Osamu Matsui</li><li>, Fumiaki Ueda</li><li>, Yasuji Ryu</li><li>, Masanobu Sakamoto</li><li>, Yasuomi Ouchi</li><li>, Yumiko Fujita</li><li>, Madoka Chita</li><li>, Rika Majima</li><li>, Hiromi Tsubota</li><li>, Umeo Shirasawa</li><li>, Masashi Sugimori</li><li>, Wataru Ariya</li><li>, Yuuzou Hagiwara</li><li>, Yasuo Tanizaki</li><li>, Hidenao Fukuyama</li><li>, Shizuko Tanaka-Urayama</li><li>, Shin-Ichi Urayama</li><li>, Ryosuke Takahashi</li><li>, Kengo Uemura</li><li>, Hajime Takechi</li><li>, Chihiro Namiki</li><li>, Takeshi Kihara</li><li>, Hiroshi Yamauchi</li><li>, Emiko Maeda</li><li>, Natsu Saito</li><li>, Shiho Satomi</li><li>, Konomi Kabata</li><li>, Tomohisa Okada</li><li>, Koichi Ishizu</li><li>, Shigeto Kawase</li><li>, Satoshi Fukumoto</li><li>, Masanori Nakagawa</li><li>, Masaki Kondo</li><li>, Fumitoshi Niwa</li><li>, Toshiki Mizuno</li><li>, Yoko Oishi</li><li>, Mariko Yamazaki</li><li>, Daisuke Yamaguchi</li><li>, Takahiko Tokuda</li><li>, Kyoko Ito</li><li>, Yoku Asano</li><li>, Chizuru Hamaguchi</li><li>, Kei Yamada</li><li>, Chio Okuyama</li><li>, Kentaro Akazawa</li><li>, Shigenori Matsushima</li><li>, Takamasa Matsuo</li><li>, Toshiaki Nakagawa</li><li>, Takeshi Nii</li><li>, Takuji Nishida</li><li>, Kuniaki Kiuchi</li><li>, Masami Fukusumi</li><li>, Hideyuki Watanabe</li><li>, Toshiaki Taoka</li><li>, Akihiro Nogi</li><li>, Masatoshi Takeda</li><li>, Toshihisa Tanaka</li><li>, Hiroaki Kazui</li><li>, Takashi Kudo</li><li>, Masayasu Okochi</li><li>, Takashi Morihara</li><li>, Shinji Tagami</li><li>, Masahiko Takaya</li><li>, Tamiki Wada</li><li>, Mikiko Yokokoji</li><li>, Hiromichi Sugiyama</li><li>, Daisuke Yamamoto</li><li>, Keiko Nomura</li><li>, Mutsumi Tomioka</li><li>, Naoyuki Sato</li><li>, Noriyuki Hayashi</li><li>, Shuko Takeda</li><li>, Eiichi Uchida</li><li>, Yoshiyuki Ikeda</li><li>, Mineto Murakami</li><li>, Takami Miki</li><li>, Hiroyuki Shimada</li><li>, Suzuka Ataka</li><li>, Akitoshi Takeda</li><li>, Yuki Iwamoto</li><li>, Motokatsu Kanemoto</li><li>, Jun Takeuchi</li><li>, Rie Azuma</li><li>, Naomi Tagawa</li><li>, Junko Masao</li><li>, Yuka Matsumoto</li><li>, Yuko Kikukawa</li><li>, Hisako Fujii</li><li>, Junko Matsumura</li><li>, Susumu Shiomi</li><li>, Joji Kawabe</li><li>, Yoshihiro Shimonishi</li><li>, Mitsuji Higashida</li><li>, Tomohiro Sahara</li><li>, Takashi Yamanaga</li><li>, Yukio Miki</li><li>, Shinichi Sakamoto</li><li>, Hiroyuki Tsushima</li><li>, Kiyoshi Maeda</li><li>, Yasuji Yamamoto</li><li>, Kazuo Sakai</li><li>, Haruhiko Oda</li><li>, Yoshihiko Tahara</li><li>, Toshio Kawamata</li><li>, Taichi Akisaki</li><li>, Mizuho Adachi</li><li>, Masako Kuranaga</li><li>, Sachi Takegawa</li><li>, Seishi Terada</li><li>, Yuki Kishimoto</li><li>, Naoya Takeda</li><li>, Nao Imai</li><li>, Mayumi Yabe</li><li>, Reiko Wada</li><li>, Takeshi Ishihara</li><li>, Hajime Honda</li><li>, Osamu Yokota</li><li>, Kentaro Ida</li><li>, Daigo Anami</li><li>, Seiji Inoue</li><li>, Toshi Matsushita</li><li>, Shinsuke Hiramatsu</li><li>, Hiromi Tonbara</li><li>, Reiko Yamamoto</li><li>, Kenji Nakashima</li><li>, Kenji Wada-Isoe</li><li>, Saori Yamasaki</li><li>, Eijiro Yamashita</li><li>, Yu Nakamura</li><li>, Ichiro Ishikawa</li><li>, Sonoko Danjo</li><li>, Tomomi Shinohara</li><li>, Yuka Kashimoto</li><li>, Miyuki Ueno</li><li>, Yoshihiro Nishiyama</li><li>, Yuka Yamamoto</li><li>, Narihide Kimura</li><li>, Kazuo Ogawa</li><li>, Yasuhiro Sasakawa</li><li>, Takashi Ishimori</li><li>, Yukito Maeda</li><li>, Tatsuo Yamada</li><li>, Shinji Ouma</li><li>, Aika Fukuhara-Kaneumi</li><li>, Nami Sakamoto</li><li>, Rie Nagao</li><li>, Kengo Yoshimitsu</li><li>, Yasuo Kuwabara</li><li>, Ryuji Nakamuta</li><li>, Minoru Tanaka</li><li>, Manabu Ikeda</li><li>, Yuusuke Yatabe</li><li>, Mamoru Hashimoto</li><li>, Keiichirou Kaneda</li><li>, Kazuki Honda</li><li>, Naoko Ichimi</li><li>, Mariko Morinaga</li><li>, Miyako Noda</li><li>, Fumi Akatuka</li><li>, Mika Kitajima</li><li>, Toshinori Hirai</li><li>, Shinya Shiraishi</li><li>, Naoji Amano</li><li>, Shinsuke Washizuka</li><li>, Tetsuya Hagiwara</li><li>, Yatsuka Okada</li><li>, Tomomi Ogihara</li><li>, Toru Takahashi</li><li>, Shin Inuzuka</li><li>, Nobuhiro Sugiyama</li><li>, Takehiko Yasaki</li><li>, Minori Kitayama</li><li>, Tomonori Owa</li><li>, Akiko Ryokawa</li><li>, Rie Takeuchi</li><li>, Satoe Goto</li><li>, Keiko Yamauchi</li><li>, Mie Ito</li><li>, Tomoki Kaneko</li><li>, Hitoshi Ueda</li><li>, Shuichi Ikeda</li><li>, Ban Mihara</li><li>, Hirofumi Kubo</li><li>, Akiko Takano</li><li>, Gou Yasui</li><li>, Masami Akuzawa</li><li>, Kaori Yamaguchi</li><li>, Toshinari Odawara</li><li>, Naomi Oota</li><li>, Megumi Shimamura</li><li>, Mikiko Sugiyama</li><li>, Atsushi Watanabe</li><li>, Shigeo Takebayashi</li><li>, Yoshigazu Hayakawa</li><li>, Mitsuhiro Idegawa</li><li>, Noriko Toya</li><li> &amp; Kazunari Ishii</li></ul><h3>Corresponding authors</h3><p>Correspondence to Masataka Kikuchi or Takeshi Ikeuchi.</p><p><b>Open Access</b> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.</p>\n<p>Reprints and permissions</p><img alt=\"Check for updates. Verify currency and authenticity via CrossMark\" height=\"81\" loading=\"lazy\" src=\"data:image/svg+xml;base64,<svg height="81" width="57" xmlns="http://www.w3.org/2000/svg"><g fill="none" fill-rule="evenodd"><path d="m17.35 35.45 21.3-14.2v-17.03h-21.3" fill="#989898"/><path d="m38.65 35.45-21.3-14.2v-17.03h21.3" fill="#747474"/><path d="m28 .5c-12.98 0-23.5 10.52-23.5 23.5s10.52 23.5 23.5 23.5 23.5-10.52 23.5-23.5c0-6.23-2.48-12.21-6.88-16.62-4.41-4.4-10.39-6.88-16.62-6.88zm0 41.25c-9.8 0-17.75-7.95-17.75-17.75s7.95-17.75 17.75-17.75 17.75 7.95 17.75 17.75c0 4.71-1.87 9.22-5.2 12.55s-7.84 5.2-12.55 5.2z" fill="#535353"/><path d="m41 36c-5.81 6.23-15.23 7.45-22.43 2.9-7.21-4.55-10.16-13.57-7.03-21.5l-4.92-3.11c-4.95 10.7-1.19 23.42 8.78 29.71 9.97 6.3 23.07 4.22 30.6-4.86z" fill="#9c9c9c"/><path d="m.2 58.45c0-.75.11-1.42.33-2.01s.52-1.09.91-1.5c.38-.41.83-.73 1.34-.94.51-.22 1.06-.32 1.65-.32.56 0 1.06.11 1.51.35.44.23.81.5 1.1.81l-.91 1.01c-.24-.24-.49-.42-.75-.56-.27-.13-.58-.2-.93-.2-.39 0-.73.08-1.05.23-.31.16-.58.37-.81.66-.23.28-.41.63-.53 1.04-.13.41-.19.88-.19 1.39 0 1.04.23 1.86.68 2.46.45.59 1.06.88 1.84.88.41 0 .77-.07 1.07-.23s.59-.39.85-.68l.91 1c-.38.43-.8.76-1.28.99-.47.22-1 .34-1.58.34-.59 0-1.13-.1-1.64-.31-.5-.2-.94-.51-1.31-.91-.38-.4-.67-.9-.88-1.48-.22-.59-.33-1.26-.33-2.02zm8.4-5.33h1.61v2.54l-.05 1.33c.29-.27.61-.51.96-.72s.76-.31 1.24-.31c.73 0 1.27.23 1.61.71.33.47.5 1.14.5 2.02v4.31h-1.61v-4.1c0-.57-.08-.97-.25-1.21-.17-.23-.45-.35-.83-.35-.3 0-.56.08-.79.22-.23.15-.49.36-.78.64v4.8h-1.61zm7.37 6.45c0-.56.09-1.06.26-1.51.18-.45.42-.83.71-1.14.29-.3.63-.54 1.01-.71.39-.17.78-.25 1.18-.25.47 0 .88.08 1.23.24.36.16.65.38.89.67s.42.63.54 1.03c.12.41.18.84.18 1.32 0 .32-.02.57-.07.76h-4.36c.07.62.29 1.1.65 1.44.36.33.82.5 1.38.5.29 0 .57-.04.83-.13s.51-.21.76-.37l.55 1.01c-.33.21-.69.39-1.09.53-.41.14-.83.21-1.26.21-.48 0-.92-.08-1.34-.25-.41-.16-.76-.4-1.07-.7-.31-.31-.55-.69-.72-1.13-.18-.44-.26-.95-.26-1.52zm4.6-.62c0-.55-.11-.98-.34-1.28-.23-.31-.58-.47-1.06-.47-.41 0-.77.15-1.07.45-.31.29-.5.73-.58 1.3zm2.5.62c0-.57.09-1.08.28-1.53.18-.44.43-.82.75-1.13s.69-.54 1.1-.71c.42-.16.85-.24 1.31-.24.45 0 .84.08 1.17.23s.61.34.85.57l-.77 1.02c-.19-.16-.38-.28-.56-.37-.19-.09-.39-.14-.61-.14-.56 0-1.01.21-1.35.63-.35.41-.52.97-.52 1.67 0 .69.17 1.24.51 1.66.34.41.78.62 1.32.62.28 0 .54-.06.78-.17.24-.12.45-.26.64-.42l.67 1.03c-.33.29-.69.51-1.08.65-.39.15-.78.23-1.18.23-.46 0-.9-.08-1.31-.24-.4-.16-.75-.39-1.05-.7s-.53-.69-.7-1.13c-.17-.45-.25-.96-.25-1.53zm6.91-6.45h1.58v6.17h.05l2.54-3.16h1.77l-2.35 2.8 2.59 4.07h-1.75l-1.77-2.98-1.08 1.23v1.75h-1.58zm13.69 1.27c-.25-.11-.5-.17-.75-.17-.58 0-.87.39-.87 1.16v.75h1.34v1.27h-1.34v5.6h-1.61v-5.6h-.92v-1.2l.92-.07v-.72c0-.35.04-.68.13-.98.08-.31.21-.57.4-.79s.42-.39.71-.51c.28-.12.63-.18 1.04-.18.24 0 .48.02.69.07.22.05.41.1.57.17zm.48 5.18c0-.57.09-1.08.27-1.53.17-.44.41-.82.72-1.13.3-.31.65-.54 1.04-.71.39-.16.8-.24 1.23-.24s.84.08 1.24.24c.4.17.74.4 1.04.71s.54.69.72 1.13c.19.45.28.96.28 1.53s-.09 1.08-.28 1.53c-.18.44-.42.82-.72 1.13s-.64.54-1.04.7-.81.24-1.24.24-.84-.08-1.23-.24-.74-.39-1.04-.7c-.31-.31-.55-.69-.72-1.13-.18-.45-.27-.96-.27-1.53zm1.65 0c0 .69.14 1.24.43 1.66.28.41.68.62 1.18.62.51 0 .9-.21 1.19-.62.29-.42.44-.97.44-1.66 0-.7-.15-1.26-.44-1.67-.29-.42-.68-.63-1.19-.63-.5 0-.9.21-1.18.63-.29.41-.43.97-.43 1.67zm6.48-3.44h1.33l.12 1.21h.05c.24-.44.54-.79.88-1.02.35-.24.7-.36 1.07-.36.32 0 .59.05.78.14l-.28 1.4-.33-.09c-.11-.01-.23-.02-.38-.02-.27 0-.56.1-.86.31s-.55.58-.77 1.1v4.2h-1.61zm-47.87 15h1.61v4.1c0 .57.08.97.25 1.2.17.24.44.35.81.35.3 0 .57-.07.8-.22.22-.15.47-.39.73-.73v-4.7h1.61v6.87h-1.32l-.12-1.01h-.04c-.3.36-.63.64-.98.86-.35.21-.76.32-1.24.32-.73 0-1.27-.24-1.61-.71-.33-.47-.5-1.14-.5-2.02zm9.46 7.43v2.16h-1.61v-9.59h1.33l.12.72h.05c.29-.24.61-.45.97-.63.35-.17.72-.26 1.1-.26.43 0 .81.08 1.15.24.33.17.61.4.84.71.24.31.41.68.53 1.11.13.42.19.91.19 1.44 0 .59-.09 1.11-.25 1.57-.16.47-.38.85-.65 1.16-.27.32-.58.56-.94.73-.35.16-.72.25-1.1.25-.3 0-.6-.07-.9-.2s-.59-.31-.87-.56zm0-2.3c.26.22.5.37.73.45.24.09.46.13.66.13.46 0 .84-.2 1.15-.6.31-.39.46-.98.46-1.77 0-.69-.12-1.22-.35-1.61-.23-.38-.61-.57-1.13-.57-.49 0-.99.26-1.52.77zm5.87-1.69c0-.56.08-1.06.25-1.51.16-.45.37-.83.65-1.14.27-.3.58-.54.93-.71s.71-.25 1.08-.25c.39 0 .73.07 1 .2.27.14.54.32.81.55l-.06-1.1v-2.49h1.61v9.88h-1.33l-.11-.74h-.06c-.25.25-.54.46-.88.64-.33.18-.69.27-1.06.27-.87 0-1.56-.32-2.07-.95s-.76-1.51-.76-2.65zm1.67-.01c0 .74.13 1.31.4 1.7.26.38.65.58 1.15.58.51 0 .99-.26 1.44-.77v-3.21c-.24-.21-.48-.36-.7-.45-.23-.08-.46-.12-.7-.12-.45 0-.82.19-1.13.59-.31.39-.46.95-.46 1.68zm6.35 1.59c0-.73.32-1.3.97-1.71.64-.4 1.67-.68 3.08-.84 0-.17-.02-.34-.07-.51-.05-.16-.12-.3-.22-.43s-.22-.22-.38-.3c-.15-.06-.34-.1-.58-.1-.34 0-.68.07-1 .2s-.63.29-.93.47l-.59-1.08c.39-.24.81-.45 1.28-.63.47-.17.99-.26 1.54-.26.86 0 1.51.25 1.93.76s.63 1.25.63 2.21v4.07h-1.32l-.12-.76h-.05c-.3.27-.63.48-.98.66s-.73.27-1.14.27c-.61 0-1.1-.19-1.48-.56-.38-.36-.57-.85-.57-1.46zm1.57-.12c0 .3.09.53.27.67.19.14.42.21.71.21.28 0 .54-.07.77-.2s.48-.31.73-.56v-1.54c-.47.06-.86.13-1.18.23-.31.09-.57.19-.76.31s-.33.25-.41.4c-.09.15-.13.31-.13.48zm6.29-3.63h-.98v-1.2l1.06-.07.2-1.88h1.34v1.88h1.75v1.27h-1.75v3.28c0 .8.32 1.2.97 1.2.12 0 .24-.01.37-.04.12-.03.24-.07.34-.11l.28 1.19c-.19.06-.4.12-.64.17-.23.05-.49.08-.76.08-.4 0-.74-.06-1.02-.18-.27-.13-.49-.3-.67-.52-.17-.21-.3-.48-.37-.78-.08-.3-.12-.64-.12-1.01zm4.36 2.17c0-.56.09-1.06.27-1.51s.41-.83.71-1.14c.29-.3.63-.54 1.01-.71.39-.17.78-.25 1.18-.25.47 0 .88.08 1.23.24.36.16.65.38.89.67s.42.63.54 1.03c.12.41.18.84.18 1.32 0 .32-.02.57-.07.76h-4.37c.08.62.29 1.1.65 1.44.36.33.82.5 1.38.5.3 0 .58-.04.84-.13.25-.09.51-.21.76-.37l.54 1.01c-.32.21-.69.39-1.09.53s-.82.21-1.26.21c-.47 0-.92-.08-1.33-.25-.41-.16-.77-.4-1.08-.7-.3-.31-.54-.69-.72-1.13-.17-.44-.26-.95-.26-1.52zm4.61-.62c0-.55-.11-.98-.34-1.28-.23-.31-.58-.47-1.06-.47-.41 0-.77.15-1.08.45-.31.29-.5.73-.57 1.3zm3.01 2.23c.31.24.61.43.92.57.3.13.63.2.98.2.38 0 .65-.08.83-.23s.27-.35.27-.6c0-.14-.05-.26-.13-.37-.08-.1-.2-.2-.34-.28-.14-.09-.29-.16-.47-.23l-.53-.22c-.23-.09-.46-.18-.69-.3-.23-.11-.44-.24-.62-.4s-.33-.35-.45-.55c-.12-.21-.18-.46-.18-.75 0-.61.23-1.1.68-1.49.44-.38 1.06-.57 1.83-.57.48 0 .91.08 1.29.25s.71.36.99.57l-.74.98c-.24-.17-.49-.32-.73-.42-.25-.11-.51-.16-.78-.16-.35 0-.6.07-.76.21-.17.15-.25.33-.25.54 0 .14.04.26.12.36s.18.18.31.26c.14.07.29.14.46.21l.54.19c.23.09.47.18.7.29s.44.24.64.4c.19.16.34.35.46.58.11.23.17.5.17.82 0 .3-.06.58-.17.83-.12.26-.29.48-.51.68-.23.19-.51.34-.84.45-.34.11-.72.17-1.15.17-.48 0-.95-.09-1.41-.27-.46-.19-.86-.41-1.2-.68z" fill="#535353"/></g></svg>\" width=\"57\"/><h3>Cite this article</h3><p>Kikuchi, M., Miyashita, A., Hara, N. <i>et al.</i> Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population. <i>Alz Res Therapy</i> <b>16</b>, 158 (2024). https://doi.org/10.1186/s13195-024-01514-8</p><p>Download citation<svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-download-medium\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></p><ul data-test=\"publication-history\"><li><p>Published<span>: </span><span><time datetime=\"2024-07-10\">10 July 2024</time></span></p></li><li><p>DOI</abbr><span>: </span><span>https://doi.org/10.1186/s13195-024-01514-8</span></p></li></ul><h3>Share this article</h3><p>Anyone you share the following link with will be able to read this content:</p><button data-track=\"click\" data-track-action=\"get shareable link\" data-track-external=\"\" data-track-label=\"button\" type=\"button\">Get shareable link</button><p>Sorry, a shareable link is not currently available for this article.</p><p data-track=\"click\" data-track-action=\"select share url\" data-track-label=\"button\"></p><button data-track=\"click\" data-track-action=\"copy share url\" data-track-external=\"\" data-track-label=\"button\" type=\"button\">Copy to clipboard</button><p> Provided by the Springer Nature SharedIt content-sharing initiative </p>","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":null,"pages":null},"PeriodicalIF":7.9000,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's Research & Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13195-024-01514-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Correction: Alz Res Therapy 16, 45 (2024)

https://doi.org/10.1186/s13195-024-01414-x


Following publication of the original article [1], the authors corrected an error in Fig. 2.

Fig. 2
Abstract Image

The PRS.noAPOE and PRS.adjLD correlated with CSF Tau/Aβ42 ratios in the MCI. CSF tTau/Aβ42 (A, C) and pTau/Aβ42 (B, D) ratios by decile of PRS are shown in each diagnostic group. The participants were divided into ten groups based on the PRS.noAPOE, ranging from the lowest group (1st decile) to the highest group (10th decile). CN = cognitively normal; MCI = mild cognitive impairment; ADD = Alzheimer’s disease dementia

Full size image

Error: Figs. 2C and D are the same figures as Figs. 2A and B in the published article.

The corrected figure is given below:

The original article [1] has been updated.

  1. Kikuchi M, Miyashita A, Hara N, et al. Polygenic effects on the risk of Alzheimer’s disease in the Japanese population. Alz Res Therapy. 2024;16:45. https://doi.org/10.1186/s13195-024-01414-x.

    Article CAS Google Scholar

Download references

Authors and Affiliations

  1. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Science, The University of Tokyo, 6‑2‑3 Kashiwanoha, Kashiwa, Chiba, 277‑0882, Japan

    Masataka Kikuchi & Akihiro Nakaya

  2. Department of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan

    Masataka Kikuchi

  3. Department of Molecular Genetics, Brain Research Institute, Niigata University, 1‑757 Asahimachi, Niigata, 951‑8585, Japan

    Akinori Miyashita, Norikazu Hara, Kensaku Kasuga & Takeshi Ikeuchi

  4. Brain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute of Geriatrics and Gerontology, Tokyo, Japan

    Yuko Saito & Shigeo Murayama

  5. Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Osaka, Japan

    Shigeo Murayama

  6. Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan

    Akiyoshi Kakita

  7. Department of General Medicine & General Internal Medicine, Nagoya City University Graduate School of Medicine, Nagoya, Japan

    Hiroyasu Akatsu

  8. Medical Genome Center, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan

    Kouichi Ozaki

  9. RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan

    Kouichi Ozaki

  10. Core Facility Administration, National Center for Geriatrics and Gerontology, Research Institute, Aichi, Japan

    Shumpei Niida

  11. Social Welfare Corporation Asahigawaso, Asahigawaso Research Institute, Okayama, Japan

    Ryozo Kuwano

  12. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Takeshi Iwatsubo

Authors
  1. Masataka KikuchiView author publications

    You can also search for this author in PubMed Google Scholar

  2. Akinori MiyashitaView author publications

    You can also search for this author in PubMed Google Scholar

  3. Norikazu HaraView author publications

    You can also search for this author in PubMed Google Scholar

  4. Kensaku KasugaView author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuko SaitoView author publications

    You can also search for this author in PubMed Google Scholar

  6. Shigeo MurayamaView author publications

    You can also search for this author in PubMed Google Scholar

  7. Akiyoshi KakitaView author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroyasu AkatsuView author publications

    You can also search for this author in PubMed Google Scholar

  9. Kouichi OzakiView author publications

    You can also search for this author in PubMed Google Scholar

  10. Shumpei NiidaView author publications

    You can also search for this author in PubMed Google Scholar

  11. Ryozo KuwanoView author publications

    You can also search for this author in PubMed Google Scholar

  12. Takeshi IwatsuboView author publications

    You can also search for this author in PubMed Google Scholar

  13. Akihiro NakayaView author publications

    You can also search for this author in PubMed Google Scholar

  14. Takeshi IkeuchiView author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the Alzheimer’s Disease Neuroimaging Initiative

  • Michael W. Weiner
  • , Sara S. Mason
  • , Colleen S. Albers
  • , David Knopman
  • , Kris Johnson
  • , Paul Aisen
  • , Ronald Petersen
  • , Clifford R. Jack
  • , William Jagust
  • , John Q. Trojanowki
  • , Arthur W. Toga
  • , Lon S. Schneider
  • , Sonia Pawluczyk
  • , Mauricio Beccera
  • , Liberty Teodoro
  • , Bryan M. Spann
  • , Laurel Beckett
  • , Robert C. Green
  • , John Morris
  • , Leslie M. Shaw
  • , Beau Ances
  • , John C. Morris
  • , Maria Carroll
  • , Mary L. Creech
  • , Erin Franklin
  • , Mark A. Mintun
  • , Stacy Schneider
  • , Angela Oliver
  • , Jeffrey Kaye
  • , Joseph Quinn
  • , Lisa Silbert
  • , Betty Lind
  • , Raina Carter
  • , Sara Dolen
  • , James Brewer
  • , Helen Vanderswag
  • , Adam Fleisher
  • , Judith L. Heidebrink
  • , Joanne L. Lord
  • , Rachelle S. Doody
  • , Javier Villanueva-Meyer
  • , Munir Chowdhury
  • , Susan Rountree
  • , Mimi Dang
  • , Yaakov Stern
  • , Lawrence S. Honig
  • , Karen L. Bell
  • , Daniel Marson
  • , Randall Griffith
  • , David Clark
  • , David Geldmacher
  • , John Brockington
  • , Erik Roberson
  • , Marissa Natelson Love
  • , Hillel Grossman
  • , Effie Mitsis
  • , Raj C. Shah
  • , Leyla deToledo-Morrell
  • , Ranjan Duara
  • , Daniel Varon
  • , Maria T. Greig
  • , Peggy Roberts
  • , Marilyn Albert
  • , Chiadi Onyike
  • , Daniel D’Agostino
  • , Stephanie Kielb
  • , James E. Galvin
  • , Brittany Cerbone
  • , Christina A. Michel
  • , Dana M. Pogorelec
  • , Henry Rusinek
  • , Mony J. de Leon
  • , Lidia Glodzik
  • , Susan De Santi
  • , P. Murali Doraiswamy
  • , Jeffrey R. Petrella
  • , Salvador Borges-Neto
  • , Terence Z. Wong
  • , Edward Coleman
  • , Charles D. Smith
  • , Greg Jicha
  • , Peter Hardy
  • , Partha Sinha
  • , Elizabeth Oates
  • , Gary Conrad
  • , Anton P. Porsteinsson
  • , Bonnie S. Goldstein
  • , Kim Martin
  • , Kelly M. Makino
  • , M. Saleem Ismail
  • , Connie Brand
  • , Ruth A. Mulnard
  • , Gaby Thai
  • , Catherine Mc-Adams-Ortiz
  • , Kyle Womack
  • , Dana Mathews
  • , Mary Quiceno
  • , Allan I. Levey
  • , James J. Lah
  • , Janet S. Cellar
  • , Jeffrey M. Burns
  • , Russell H. Swerdlow
  • , William M. Brooks
  • , Liana Apostolova
  • , Martin R. Farlow
  • , Ann Marie Hake
  • , Brandy R. Matthews
  • , Jared R. Brosch
  • , Scott Herring
  • , Cynthia Hunt
  • , Kathleen Tingus
  • , Ellen Woo
  • , Daniel H. S. Silverman
  • , Po H. Lu
  • , George Bartzokis
  • , Neill R. Graff-Radford
  • , Francine Parfitt
  • , Tracy Kendall
  • , Heather Johnson
  • , Christopher H. van Dyck
  • , Richard E. Carson
  • , Martha G. MacAvoy
  • , Pradeep Varma
  • , Howard Chertkow
  • , Howard Bergman
  • , Chris Hosein
  • , Sandra Black
  • , Bojana Stefanovic
  • , Curtis Caldwell
  • , Ging-Yuek Robin Hsiung
  • , Howard Feldman
  • , Benita Mudge
  • , Michele Assaly
  • , Elizabeth Finger
  • , Stephen Pasternack
  • , Irina Rachisky
  • , Dick Trost
  • , Andrew Kertesz
  • , Charles Bernick
  • , Donna Munic
  • , Marek Marsel Mesulam
  • , Kristine Lipowski
  • , Sandra Weintraub
  • , Borna Bonakdarpour
  • , Diana Kerwin
  • , Chuang-Kuo Wu
  • , Nancy Johnson
  • , Carl Sadowsky
  • , Teresa Villena
  • , Raymond Scott Turner
  • , Kathleen Johnson
  • , Brigid Reynolds
  • , Reisa A. Sperling
  • , Keith A. Johnson
  • , Gad Marshall
  • , Jerome Yesavage
  • , Joy L. Taylor
  • , Barton Lane
  • , Allyson Rosen
  • , Jared Tinklenberg
  • , Marwan N. Sabbagh
  • , Christine M. Belden
  • , Sandra A. Jacobson
  • , Sherye A. Sirrel
  • , Neil Kowall
  • , Ronald Killiany
  • , Andrew E. Budson
  • , Alexander Norbash
  • , Patricia Lynn Johnson
  • , Thomas O. Obisesan
  • , Saba Wolday
  • , Joanne Allard
  • , Alan Lerner
  • , Paula Ogrocki
  • , Curtis Tatsuoka
  • , Parianne Fatica
  • , Evan Fletcher
  • , Pauline Maillard
  • , John Olichney
  • , Charles DeCarli
  • , Owen Carmichael
  • , Smita Kittur
  • , Michael Borrie
  • , T.-Y. Lee
  • , Rob Bartha
  • , Sterling Johnson
  • , Sanjay Asthana
  • , Cynthia M. Carlsson
  • , Steven G. Potkin
  • , Adrian Preda
  • , Dana Nguyen
  • , Pierre Tariot
  • , Anna Burke
  • , Nadira Trncic
  • , Stephanie Reeder
  • , Vernice Bates
  • , Horacio Capote
  • , Michelle Rainka
  • , Douglas W. Scharre
  • , Maria Kataki
  • , Anahita Adeli
  • , Earl A. Zimmerman
  • , Dzintra Celmins
  • , Alice D. Brown
  • , Godfrey D. Pearlson
  • , Karen Blank
  • , Karen Anderson
  • , Laura A. Flashman
  • , Marc Seltzer
  • , Mary L. Hynes
  • , Robert B. Santulli
  • , Kaycee M. Sink
  • , Leslie Gordineer
  • , Jeff D. Williamson
  • , Pradeep Garg
  • , Franklin Watkins
  • , Brian R. Ott
  • , Henry Querfurth
  • , Geoffrey Tremont
  • , Stephen Salloway
  • , Paul Malloy
  • , Stephen Correia
  • , Howard J. Rosen
  • , Bruce L. Miller
  • , David Perry
  • , Jacobo Mintzer
  • , Kenneth Spicer
  • , David Bachman
  • , Nunzio Pomara
  • , Raymundo Hernando
  • , Antero Sarrael
  • , Norman Relkin
  • , Gloria Chaing
  • , Michael Lin
  • , Lisa Ravdin
  • , Amanda Smith
  • , Balebail Ashok Raj
  •  & Kristin Fargher

the Japanese Alzheimer’s Disease Neuroimaging Initiative

  • Takeshi Iwatsubo
  • , Takashi Asada
  • , Hiroyuki Arai
  • , Morihiro Sugishita
  • , Hiroshi Matsuda
  • , Noriko Sato
  • , Hajime Sato
  • , Kengo Ito
  • , Teruhiko Kachi
  • , Kenji Toba
  • , Michio Senda
  • , Kenji Ishii
  • , Ryozo Kuwano
  • , Takeshi Ikeuchi
  • , Shun Shimohama
  • , Masaki Saitoh
  • , Rika Yamauchi
  • , Takashi Hayashi
  • , Chiyoko Takanami
  • , Seiju Kobayashi
  • , Norihito Nakano
  • , Junichiro Kanazawa
  • , Takeshi Ando
  • , Masato Hareyama
  • , Masamitsu Hatakenaka
  • , Eriko Tsukamoto
  • , Shinji Ochi
  • , Mikio Shoji
  • , Etsuro Matsubara
  • , Takeshi Kawarabayashi
  • , Yasuhito Wakasaya
  • , Takashi Nakata
  • , Naoko Nakahata
  • , Shuichi Ono
  • , Yoshihiro Takai
  • , Satoshi Takahashi
  • , Hisashi Yonezawa
  • , Junko Takahashi
  • , Masako Kudoh
  • , Kuniko Ueno
  • , Hiromi Sakashita
  • , Kuniko Watanabe
  • , Makoto Sasaki
  • , Yutaka Matsumura
  • , Yohsuke Hirata
  • , Tsuyoshi Metoki
  • , Susumu Hayakawa
  • , Yuichi Sato
  • , Masayuki Takeda
  • , Koichiro Sera
  • , Kazunori Terasaki
  • , Toshiaki Sasaki
  • , Yoshihiro Saitoh
  • , Shoko Goto
  • , Ken Nagata
  • , Tetsuya Maeda
  • , Yasushi Kondoh
  • , Takashi Yamazaki
  • , Daiki Takano
  • , Mio Miyata
  • , Hiromi Komatsu
  • , Mayumi Watanabe
  • , Tomomi Sinoda
  • , Rena Muraoka
  • , Kayoko Kikuchi
  • , Hitomi Ito
  • , Aki Sato
  • , Toshibumi Kinoshita
  • , Hideyo Toyoshima
  • , Kaoru Sato
  • , Shigeki Sugawara
  • , Isao Ito
  • , Fumiko Kumagai
  • , Katsutoshi Furukawa
  • , Masaaki Waragai
  • , Naoki Tomita
  • , Mari Ootsuki
  • , Katsumi Sugawara
  • , Satomi Sugawara
  • , Nobuyuki Okamura
  • , Shunji Mugikura
  • , Atsushi Umetsu
  • , Takanori Murata
  • , Tatsuo Nagasaka
  • , Yukitsuka Kudo
  • , Manabu Tashiro
  • , Shoichi Watanuki
  • , Masatoyo Nishizawa
  • , Takayoshi Tokutake
  • , Saeri Ishikawa
  • , Emiko Kishida
  • , Nozomi Sato
  • , Mieko Hagiwara
  • , Kumi Yamanaka
  • , Takeyuki Watanabe
  • , Taeko Takasugi
  • , Shoichi Inagawa
  • , Kenichi Naito
  • , Masanori Awaji
  • , Tsutomu Kanazawa
  • , Kouiti Okamoto
  • , Masaki Ikeda
  • , Yuiti Tasiro
  • , Syunn Nagamine
  • , Sathiko Kurose
  • , Tsuneo Yamazaki
  • , Shiori Katsuyama
  • , Sayuri Fukushima
  • , Etsuko Koya
  • , Makoto Amanuma
  • , Kouiti Ujita
  • , Kazuhiro Kishi
  • , Kazuhisa Tuda
  • , Noboru Oriuti
  • , Katsuyoshi Mizukami
  • , Tetsuaki Arai
  • , Etsuko Nakajima
  • , Katsumi Miyamoto
  • , Tomoya Kobayashi
  • , Saori Itoya
  • , Jun Ookubo
  • , Toshiya Akatsu
  • , Yoshiko Anzai
  • , Junya Ikegaki
  • , Yuuichi Katou
  • , Kaori Kimura
  • , Hajime Saitou
  • , Kazuya Shinoda
  • , Satoka Someya
  • , Hiroko Taguchi
  • , Kazuya Tashiro
  • , Masaya Tanaka
  • , Tatsuya Nemoto
  • , Ryou Wakabayashi
  • , Daisuke Watanabe
  • , Kousaku Saotome
  • , Ryou Kuchii
  • , Harumasa Takano
  • , Tetsuya Suhara
  • , Hitoshi Shinoto
  • , Hitoshi Shimada
  • , Makoto Higuchi
  • , Takaaki Mori
  • , Hiroshi Ito
  • , Takayuki Obata
  • , Yoshiko Fukushima
  • , Kazuko Suzuki
  • , Izumi Izumida
  • , Katsuyuki Tanimoto
  • , Takahiro Shiraishi
  • , Hitoshi Shinotoh
  • , Junko Shiba
  • , Hiroaki Yano
  • , Miki Satake
  • , Aimi Nakui
  • , Yae Ebihara
  • , Tomomi Hasegawa
  • , Yasumasa Yoshiyama
  • , Mami Kato
  • , Yuki Ogata
  • , Hiroyuki Fujikawa
  • , Nobuo Araki
  • , Yoshihiko Nakazato
  • , Takahiro Sasaki
  • , Tomokazu Shimadu
  • , Kimiko Yoshimaru
  • , Etsuko Imabayashi
  • , Asako Yasuda
  • , Keiko Ozawa
  • , Etuko Yamamoto
  • , Natsumi Nakamata
  • , Noriko Miyauchi
  • , Rieko Hashimoto
  • , Taishi Unezawa
  • , Takafumi Ichikawa
  • , Hiroki Hayashi
  • , Masakazu Yamagishi
  • , Tunemichi Mihara
  • , Masaya Hirano
  • , Shinichi Watanabe
  • , Junichiro Fukuhara
  • , Hajime Matsudo
  • , Nobuyuki Saito
  • , Atsushi Iwata
  • , Hisatomo Kowa
  • , Toshihiro Hayashi
  • , Ryoko Ihara
  • , Toji Miyagawa
  • , Mizuho Yoshida
  • , Yuri Koide
  • , Eriko Samura
  • , Kurumi Fujii
  • , Kaori Watanabe
  • , Nagae Orihara
  • , Toshimitsu Momose
  • , Miwako Takahashi
  • , Takuya Arai
  • , Yoshiki Kojima
  • , Akira Kunimatsu
  • , Harushi Mori
  • , Masami Goto
  • , Takeo Sarashina
  • , Syuichi Uzuki
  • , Seiji Katou
  • , Yoshiharu Sekine
  • , Yukihiro Takauchi
  • , Chiine Kagami
  • , Kazutomi Kanemaru
  • , Yasushi Nishina
  • , Maria Sakaibara
  • , Yumiko Okazaki
  • , Rieko Okada
  • , Maki Obata
  • , Shigeo Murayama
  • , Masaki Takao
  • , Yuko Iwata
  • , Mizuho Minami
  • , Yasuko Hanabusa
  • , Hanae Shingyouji
  • , Kyoko Tottori
  • , Aya Tokumaru
  • , Makoto Ichinose
  • , Kazuya Kume
  • , Syunsuke Kahashi
  • , Kunimasa Arima
  • , Shin Tanaka
  • , Yuko Nagahusa
  • , Masuhiro Sakata
  • , Mitsutoshi Okazaki
  • , Yuko Saito
  • , Maki Yamada
  • , Tadashi Tukamoto
  • , Tiine Kodama
  • , Tomoko Takeuchi
  • , Keiichiro Ozawa
  • , Yoshiko Kawaji
  • , Kyouko Tottori
  • , Yasuhiro Nakata
  • , Satoshi Sawada
  • , Makoto Mimatsu
  • , Daisuke Nakkamura
  • , Takeshi Tamaru
  • , Shunichirou Horiuchi
  • , Heii Arai
  • , Tsuneyoshi Ota
  • , Aiko Kodaka
  • , Yuko Tagata
  • , Tomoko Nakada
  • , Eizo Iseki
  • , Kiyoshi Sato
  • , Hiroshige Fujishiro
  • , Norio Murayama
  • , Masaru Suzuki
  • , Satoshi Kimura
  • , Masanobu Takahashi
  • , Haruo Hanyu
  • , Hirofumi Sakurai
  • , Takahiko Umahara
  • , Hidekazu Kanetaka
  • , Kaori Arashino
  • , Mikako Murakami
  • , Ai Kito
  • , Seiko Miyagi
  • , Kaori Doi
  • , Kazuyoshi Sasaki
  • , Mineo Yamazaki
  • , Akiko Ishiwata
  • , Yasushi Arai
  • , Akane Nogami
  • , Sumiko Fukuda
  • , Koichi Kozaki
  • , Yukiko Yamada
  • , Sayaka Kimura
  • , Ayako Machida
  • , Kuninori Kobayashi
  • , Hidehiro Mizusawa
  • , Nobuo Sanjo
  • , Mutsufusa Watanabe
  • , Takuya Ohkubo
  • , Hiromi Utashiro
  • , Yukiko Matsumoto
  • , Kumiko Hagiya
  • , Yoshiko Miyama
  • , Hitoshi Shibuya
  • , Isamu Ohashi
  • , Akira Toriihara
  • , Takako Shinozaki
  • , Haruko Hiraki
  • , Shinichi Ohtani
  • , Toshifumi Matsui
  • , Tomomi Toyama
  • , Hideki Sakurai
  • , Kumiko Sugiura
  • , Yu Hayasaka
  • , Hirofumi Taguchi
  • , Shizuo Hatashita
  • , Akari Imuta
  • , Akiko Matsudo
  • , Daichi Wakebe
  • , Hideki Hayakawa
  • , Mitsuhiro Ono
  • , Takayoshi Ohara
  • , Yukihiko Washimi
  • , Yutaka Arahata
  • , Akinori Takeda
  • , Akiko Yamaoka
  • , Masashi Tsujimoto
  • , Takiko Kawai
  • , Ai Honda
  • , Yoko Konagaya
  • , Hideyuki Hattori
  • , Kenji Yoshiyama
  • , Rina Miura
  • , Takashi Sakurai
  • , Miura Hisayuki
  • , Hidetoshi Endou
  • , Syousuke Satake
  • , Young Jae Hong
  • , Katsunari Iwai
  • , Masaki Suenaga
  • , Sumiko Morita
  • , Kengo Itou
  • , Takashi Kato
  • , Ken Fujiwara
  • , Rikio Katou
  • , Mariko Koyama
  • , Naohiko Fukaya
  • , Akira Tsuji
  • , Hitomi Shimizu
  • , Hiroyuki Fujisawa
  • , Tomoko Nakazawa
  • , Satoshi Koyama
  • , Takanori Sakata
  • , Masahito Yamada
  • , Mitsuhiro Yoshita
  • , Miharu Samuraki
  • , Kenjiro Ono
  • , Moeko Shinohara
  • , Yuki Soshi
  • , Kozue Niwa
  • , Chiaki Doumoto
  • , Mariko Hata
  • , Miyuki Matsushita
  • , Mai Tsukiyama
  • , Nozomi Takeda
  • , Sachiko Yonezawa
  • , Ichiro Matsunari
  • , Osamu Matsui
  • , Fumiaki Ueda
  • , Yasuji Ryu
  • , Masanobu Sakamoto
  • , Yasuomi Ouchi
  • , Yumiko Fujita
  • , Madoka Chita
  • , Rika Majima
  • , Hiromi Tsubota
  • , Umeo Shirasawa
  • , Masashi Sugimori
  • , Wataru Ariya
  • , Yuuzou Hagiwara
  • , Yasuo Tanizaki
  • , Hidenao Fukuyama
  • , Shizuko Tanaka-Urayama
  • , Shin-Ichi Urayama
  • , Ryosuke Takahashi
  • , Kengo Uemura
  • , Hajime Takechi
  • , Chihiro Namiki
  • , Takeshi Kihara
  • , Hiroshi Yamauchi
  • , Emiko Maeda
  • , Natsu Saito
  • , Shiho Satomi
  • , Konomi Kabata
  • , Tomohisa Okada
  • , Koichi Ishizu
  • , Shigeto Kawase
  • , Satoshi Fukumoto
  • , Masanori Nakagawa
  • , Masaki Kondo
  • , Fumitoshi Niwa
  • , Toshiki Mizuno
  • , Yoko Oishi
  • , Mariko Yamazaki
  • , Daisuke Yamaguchi
  • , Takahiko Tokuda
  • , Kyoko Ito
  • , Yoku Asano
  • , Chizuru Hamaguchi
  • , Kei Yamada
  • , Chio Okuyama
  • , Kentaro Akazawa
  • , Shigenori Matsushima
  • , Takamasa Matsuo
  • , Toshiaki Nakagawa
  • , Takeshi Nii
  • , Takuji Nishida
  • , Kuniaki Kiuchi
  • , Masami Fukusumi
  • , Hideyuki Watanabe
  • , Toshiaki Taoka
  • , Akihiro Nogi
  • , Masatoshi Takeda
  • , Toshihisa Tanaka
  • , Hiroaki Kazui
  • , Takashi Kudo
  • , Masayasu Okochi
  • , Takashi Morihara
  • , Shinji Tagami
  • , Masahiko Takaya
  • , Tamiki Wada
  • , Mikiko Yokokoji
  • , Hiromichi Sugiyama
  • , Daisuke Yamamoto
  • , Keiko Nomura
  • , Mutsumi Tomioka
  • , Naoyuki Sato
  • , Noriyuki Hayashi
  • , Shuko Takeda
  • , Eiichi Uchida
  • , Yoshiyuki Ikeda
  • , Mineto Murakami
  • , Takami Miki
  • , Hiroyuki Shimada
  • , Suzuka Ataka
  • , Akitoshi Takeda
  • , Yuki Iwamoto
  • , Motokatsu Kanemoto
  • , Jun Takeuchi
  • , Rie Azuma
  • , Naomi Tagawa
  • , Junko Masao
  • , Yuka Matsumoto
  • , Yuko Kikukawa
  • , Hisako Fujii
  • , Junko Matsumura
  • , Susumu Shiomi
  • , Joji Kawabe
  • , Yoshihiro Shimonishi
  • , Mitsuji Higashida
  • , Tomohiro Sahara
  • , Takashi Yamanaga
  • , Yukio Miki
  • , Shinichi Sakamoto
  • , Hiroyuki Tsushima
  • , Kiyoshi Maeda
  • , Yasuji Yamamoto
  • , Kazuo Sakai
  • , Haruhiko Oda
  • , Yoshihiko Tahara
  • , Toshio Kawamata
  • , Taichi Akisaki
  • , Mizuho Adachi
  • , Masako Kuranaga
  • , Sachi Takegawa
  • , Seishi Terada
  • , Yuki Kishimoto
  • , Naoya Takeda
  • , Nao Imai
  • , Mayumi Yabe
  • , Reiko Wada
  • , Takeshi Ishihara
  • , Hajime Honda
  • , Osamu Yokota
  • , Kentaro Ida
  • , Daigo Anami
  • , Seiji Inoue
  • , Toshi Matsushita
  • , Shinsuke Hiramatsu
  • , Hiromi Tonbara
  • , Reiko Yamamoto
  • , Kenji Nakashima
  • , Kenji Wada-Isoe
  • , Saori Yamasaki
  • , Eijiro Yamashita
  • , Yu Nakamura
  • , Ichiro Ishikawa
  • , Sonoko Danjo
  • , Tomomi Shinohara
  • , Yuka Kashimoto
  • , Miyuki Ueno
  • , Yoshihiro Nishiyama
  • , Yuka Yamamoto
  • , Narihide Kimura
  • , Kazuo Ogawa
  • , Yasuhiro Sasakawa
  • , Takashi Ishimori
  • , Yukito Maeda
  • , Tatsuo Yamada
  • , Shinji Ouma
  • , Aika Fukuhara-Kaneumi
  • , Nami Sakamoto
  • , Rie Nagao
  • , Kengo Yoshimitsu
  • , Yasuo Kuwabara
  • , Ryuji Nakamuta
  • , Minoru Tanaka
  • , Manabu Ikeda
  • , Yuusuke Yatabe
  • , Mamoru Hashimoto
  • , Keiichirou Kaneda
  • , Kazuki Honda
  • , Naoko Ichimi
  • , Mariko Morinaga
  • , Miyako Noda
  • , Fumi Akatuka
  • , Mika Kitajima
  • , Toshinori Hirai
  • , Shinya Shiraishi
  • , Naoji Amano
  • , Shinsuke Washizuka
  • , Tetsuya Hagiwara
  • , Yatsuka Okada
  • , Tomomi Ogihara
  • , Toru Takahashi
  • , Shin Inuzuka
  • , Nobuhiro Sugiyama
  • , Takehiko Yasaki
  • , Minori Kitayama
  • , Tomonori Owa
  • , Akiko Ryokawa
  • , Rie Takeuchi
  • , Satoe Goto
  • , Keiko Yamauchi
  • , Mie Ito
  • , Tomoki Kaneko
  • , Hitoshi Ueda
  • , Shuichi Ikeda
  • , Ban Mihara
  • , Hirofumi Kubo
  • , Akiko Takano
  • , Gou Yasui
  • , Masami Akuzawa
  • , Kaori Yamaguchi
  • , Toshinari Odawara
  • , Naomi Oota
  • , Megumi Shimamura
  • , Mikiko Sugiyama
  • , Atsushi Watanabe
  • , Shigeo Takebayashi
  • , Yoshigazu Hayakawa
  • , Mitsuhiro Idegawa
  • , Noriko Toya
  •  & Kazunari Ishii

Corresponding authors

Correspondence to Masataka Kikuchi or Takeshi Ikeuchi.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

Abstract Image

Cite this article

Kikuchi, M., Miyashita, A., Hara, N. et al. Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population. Alz Res Therapy 16, 158 (2024). https://doi.org/10.1186/s13195-024-01514-8

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/s13195-024-01514-8

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
更正：日本人患阿尔茨海默病风险的多基因影响
更正：Alz Res Therapy 16, 45 (2024)https://doi.org/10.1186/s13195-024-01414-xFollowing 原文[1]发表后，作者更正了图 2 中的一处错误。图 2 PRS.noAPOE 和 PRS.adjLD 与 MCI 中 CSF Tau/Aβ42 比率的相关性。各诊断组按 PRS 十分位数的 CSF tTau/Aβ42（A，C）和 pTau/Aβ42（B，D）比值如图所示。根据 PRS.noAPOE 将参与者分为 10 组，从最低组（第 1 十分位数）到最高组（第 10 十分位数）不等。CN = 认知正常；MCI = 轻度认知障碍；ADD = 阿尔茨海默病痴呆全图错误：Kikuchi M, Miyashita A, Hara N, et al. Polygenic effects on the risk of Alzheimer's disease in the Japanese population.Alz Res Therapy.2024;16:45. https://doi.org/10.1186/s13195-024-01414-x.Article CAS Google Scholar Download references作者及工作单位东京大学研究生院前沿科学研究科计算生物学与医学科学部，6-2-3 Kashiwanoha, Kashiwa, Chiba, 277-0882, JapanMasataka Kikuchi &amp；Akihiro NakayaDepartment of Medical Informatics, Graduate School of Medicine, Osaka University, Osaka, JapanMasataka KikuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, JapanAkinori Miyashita, Norikazu Hara, Kensaku Kasuga &amp；Takeshi Ikeuchi 老化研究脑库（神经病理学系），东京都老年医学和老年学研究所，日本东京 Yuko Saito &amp; Shigeo Murayama 神经发育、神经和精神疾病脑库，大阪大学儿童发育联合研究生院，日本大阪 Shigeo Murayama 新泻大学脑研究所病理学系，日本新泻 Akiyoshi Kakita 综合医学系 &amp；名古屋市立大学医学研究生院普通内科学部，日本名古屋赤津弘安国立老年医学和老年学中心医学基因组中心，日本爱知县，Kouichi Ozaki RIKEN Center for Integrative Medical Sciences，日本神奈川县，Kouichi OzakiCore Facility Administration、日本冈山旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川旭川研究所，日本冈山JapanTakeshi IwatsuboAuthorsMasataka KikuchiView Author publications您也可以在PubMed Google ScholarAkinori MiyashitaView Author publications您也可以在PubMed Google ScholarNorikazu HaraView Author publications您也可以在PubMed Google ScholarKensaku KasugaView Author publications您也可以在PubMed Google Scholar搜索该作者您也可以在 PubMed Google Scholar中搜索这位作者Yuko Saito查看作者发表的作品您也可以在 PubMed Google Scholar中搜索这位作者Shigeo Murayama查看作者发表的作品您也可以在 PubMed Google Scholar中搜索这位作者Akiyoshi Kakita查看作者发表的作品您也可以在 PubMed Google Scholar中搜索这位作者Hiroyasu Akatsu查看作者发表的作品您也可以在 PubMed Google Scholar中搜索这位作者Hiroyasu Akatsu查看作者发表的作品作者发表的作品您也可以在 PubMed Google Scholar中搜索该作者Kouichi Ozaki查看作者发表的作品您也可以在 PubMed Google Scholar中搜索该作者Shumpei Niida查看作者发表的作品您也可以在 PubMed Google Scholar中搜索该作者Ryozo Kuwano查看作者发表的作品您也可以在 PubMed Google Scholar中搜索该作者ScholarTakeshi IwatsuboView 作者发表作品您也可以在 PubMed Google ScholarAkihiro NakayaView 作者发表作品您也可以在 PubMed Google ScholarTakeshi IkeuchiView 作者发表作品您也可以在 PubMed Google ScholarConsortiathe Alzheimer's Disease Neuroimaging Initiative迈克尔.Weiner、Sara S. Mason、Colleen S. Albers、David Knopman、Kris Johnson、Paul Aisen、Ronald Petersen、Clifford R. Jack、William Jagust、John Q. Trojanowki、Arthur W. Toga、Lon S.Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, Laurel Beckett, Robert C. Green, John Morris, Leslie M. Shaw, Beau Ances, John C. Morris, Maria Carroll, Mary L. Creech, Erin Franklin, Mark A.Mintun, Stacy Schneider, Angela Oliver, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, Raina Carter, Sara Dolen, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Rachelle S.Doody, Javier Villanueva-Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Marissa Natelson Love, Hillel Grossman, Effie Mitsis, Raj C.
本文章由计算机程序翻译，如有差异，请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy 医学-神经病学
CiteScore
13.10
自引率
3.30%
发文量
172
审稿时长
>12 weeks
期刊介绍： Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
期刊最新文献
Facial aging, cognitive impairment, and dementia risk. Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review. Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort. Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study. Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer's disease or frontotemporal dementia.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1