Pub Date : 2026-03-24DOI: 10.1186/s13195-026-02017-4
Andrea E Zülke, Melanie Luppa, Laurenz Lammer, Susanne Röhr, Ronny Baber, Ronald Biemann, Kerstin Wirkner, Samira Zeynalova, Maryam Yahiaoui-Doktor, Silke Zachariae, Christoph Engel, Andreas Hinz, Heide Glaesmer, Matthias L Schroeter, Markus Löffler, Arno Villringer, A Veronica Witte, Frauke Beyer, Steffi G Riedel-Heller
{"title":"The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study.","authors":"Andrea E Zülke, Melanie Luppa, Laurenz Lammer, Susanne Röhr, Ronny Baber, Ronald Biemann, Kerstin Wirkner, Samira Zeynalova, Maryam Yahiaoui-Doktor, Silke Zachariae, Christoph Engel, Andreas Hinz, Heide Glaesmer, Matthias L Schroeter, Markus Löffler, Arno Villringer, A Veronica Witte, Frauke Beyer, Steffi G Riedel-Heller","doi":"10.1186/s13195-026-02017-4","DOIUrl":"https://doi.org/10.1186/s13195-026-02017-4","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147502852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-21DOI: 10.1186/s13195-026-02007-6
Adriana Gea-González, Renata Valle-Pedroso, Inmaculada López-Font, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero, María-Salud García-Ayllón
{"title":"Selective reduction of ADAM10 in brain and cerebrospinal fluid of Alzheimer's disease patients.","authors":"Adriana Gea-González, Renata Valle-Pedroso, Inmaculada López-Font, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero, María-Salud García-Ayllón","doi":"10.1186/s13195-026-02007-6","DOIUrl":"https://doi.org/10.1186/s13195-026-02007-6","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147490520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-21DOI: 10.1186/s13195-026-02019-2
Beata Borgström Bolmsjö, Josef Barbosa Djärf, Danielle van Westen, Suzanne E Schindler, Ayesha Fawad, Lyduine Collij, Ruben Smith, Niklas Mattsson-Carlgren, Erik Stomrud, Pontus Tideman, Oskar Hansson, Sebastian Palmqvist
{"title":"Eligibility for amyloid targeting therapies among primary care patients with cognitive symptoms.","authors":"Beata Borgström Bolmsjö, Josef Barbosa Djärf, Danielle van Westen, Suzanne E Schindler, Ayesha Fawad, Lyduine Collij, Ruben Smith, Niklas Mattsson-Carlgren, Erik Stomrud, Pontus Tideman, Oskar Hansson, Sebastian Palmqvist","doi":"10.1186/s13195-026-02019-2","DOIUrl":"https://doi.org/10.1186/s13195-026-02019-2","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1186/s13195-026-02015-6
Federica Agosta, Giordano Cecchetti, Edoardo G Spinelli, Alma Ghirelli, Giulia Rugarli, Stefano Pisano, Federico Coraglia, Elisa Canu, Veronica Castelnovo, Elisa Sibilla, Anna Gilioli, Chiara Tripodi, Fabiola Freri, Alessandra Bianchi, Paolo Vezzulli, Sonia Calloni, Andrea Falini, Ana Maria Samanes Gajate, Andrea Panzacchi, Gino Pepe, Camilla Ferri, Arturo Chiti, Massimo Filippi
{"title":"Real-world implementation of lecanemab and donanemab in an Italian memory center: a 1-year experience.","authors":"Federica Agosta, Giordano Cecchetti, Edoardo G Spinelli, Alma Ghirelli, Giulia Rugarli, Stefano Pisano, Federico Coraglia, Elisa Canu, Veronica Castelnovo, Elisa Sibilla, Anna Gilioli, Chiara Tripodi, Fabiola Freri, Alessandra Bianchi, Paolo Vezzulli, Sonia Calloni, Andrea Falini, Ana Maria Samanes Gajate, Andrea Panzacchi, Gino Pepe, Camilla Ferri, Arturo Chiti, Massimo Filippi","doi":"10.1186/s13195-026-02015-6","DOIUrl":"https://doi.org/10.1186/s13195-026-02015-6","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-20DOI: 10.1186/s13195-026-02005-8
Zainab Khurshid, Tong Tong, Oluwatosin Olayinka, John J Farrell, Congcong Zhu, Eden R Martin, William S Bush, Margaret A Pericak-Vance, Li-San Wang, Gerard D Schellenberg, Jonathan L Haines, Kathryn L Lunetta, Xiaoling Zhang, Lindsay A Farrer
{"title":"Interactive effects of telomere length and genetic variants on Alzheimer disease risk across multiple ancestral populations.","authors":"Zainab Khurshid, Tong Tong, Oluwatosin Olayinka, John J Farrell, Congcong Zhu, Eden R Martin, William S Bush, Margaret A Pericak-Vance, Li-San Wang, Gerard D Schellenberg, Jonathan L Haines, Kathryn L Lunetta, Xiaoling Zhang, Lindsay A Farrer","doi":"10.1186/s13195-026-02005-8","DOIUrl":"10.1186/s13195-026-02005-8","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-18DOI: 10.1186/s13195-026-02012-9
Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia
{"title":"Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer's disease using the Lumipulse platform.","authors":"Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia","doi":"10.1186/s13195-026-02012-9","DOIUrl":"https://doi.org/10.1186/s13195-026-02012-9","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1186/s13195-026-02000-z
Jetske van der Schaar, Leonie N C Visser, Eva C A Asscher, Yolande A L Pijnenburg, Christa M de Geus, Wiesje M van der Flier, Annelien L Bredenoord, Mariette A van den Hoven, Ellen M A Smets, Sven J van der Lee
{"title":"Impact of diagnostic genetic testing for familial dementia: experiences of patients and relatives.","authors":"Jetske van der Schaar, Leonie N C Visser, Eva C A Asscher, Yolande A L Pijnenburg, Christa M de Geus, Wiesje M van der Flier, Annelien L Bredenoord, Mariette A van den Hoven, Ellen M A Smets, Sven J van der Lee","doi":"10.1186/s13195-026-02000-z","DOIUrl":"https://doi.org/10.1186/s13195-026-02000-z","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1186/s13195-026-02011-w
Shayan Mostafaei, Daniel Wikström Shemer, Jonathan K L Mak, Ida K Karlsson, Sara Hägg
{"title":"Improved polygenic risk prediction for alzheimer's disease and related dementias using deep learning: age and APOE-stratified analysis.","authors":"Shayan Mostafaei, Daniel Wikström Shemer, Jonathan K L Mak, Ida K Karlsson, Sara Hägg","doi":"10.1186/s13195-026-02011-w","DOIUrl":"https://doi.org/10.1186/s13195-026-02011-w","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1186/s13195-026-01986-w
Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas T Seyfried, David W Loring, Felicia C Goldstein, Allan I Levey, James J Lah, Deqiang Qiu
{"title":"Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.","authors":"Junjie Wu, Benjamin B Risk, Taylor A James, Nicholas T Seyfried, David W Loring, Felicia C Goldstein, Allan I Levey, James J Lah, Deqiang Qiu","doi":"10.1186/s13195-026-01986-w","DOIUrl":"10.1186/s13195-026-01986-w","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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