Clinical and subclinical arteriosclerotic disease in octagenarians with hip fracture. A case–control study

IF 2.6 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL Medicina Clinica Pub Date : 2024-11-15 DOI:10.1016/j.medcli.2024.05.003
Aina Capdevila-Reniu , Margarita Navarro-López , Cristina Sierra-Benito , Victor Sapena , Ana Suárez-Lombraña , Miguel Camafort-Babkowski , Alfonso López-Soto
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Abstract

Background and objectives

Evaluate clinical and subclinical arteriosclerotic disease in older patients with hip fracture compared with patients without fracture in order to increase knowledge about the relation between both diseases in older individuals.

Patients and methods

Age- and sex-matched case–control study of octogenarians with and without recent hip fracture. Vascular risk factors, subclinical vascular diseases (assessed by carotid plaques, carotid intima media thickness and arterial stiffness) as well as cardiovascular diseases were analyzed. Univariate and multivariate logistic models were used to estimate odds ratios (OR) with their 95% confidence intervals (CI) to assess the association of the arteriosclerosis and hip fracture.

Results

We analyzed 95 patients per group with a median age of 82 [79–87] years of whom 77.9% were female. Patients in both groups have elevated rates of vascular disease (25%) without differences between them. Patients with hip fracture had higher subclinical arteriosclerotic alterations with higher percentage of carotid plaques (OR 3.25 [1.06–9.97]) compared with the control group.

Conclusions

Older patients with hip fracture had significantly higher presence of subclinical alterations but not increase on rate of cardiovascular arteriosclerotic disease compared with those without hip fracture.
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髋部骨折八旬老人的临床和亚临床动脉硬化疾病。病例对照研究。
背景和目的:评估髋部骨折老年患者与未骨折患者的临床和亚临床动脉硬化疾病:与未骨折的患者相比,评估髋部骨折老年患者的临床和亚临床动脉硬化疾病,以增加对这两种疾病在老年人中的关系的了解:患者和方法:对近期有无髋部骨折的八旬老人进行年龄和性别匹配的病例对照研究。研究分析了血管风险因素、亚临床血管疾病(通过颈动脉斑块、颈动脉内膜厚度和动脉僵化度评估)以及心血管疾病。采用单变量和多变量逻辑模型估算出几率比(OR)及其 95% 的置信区间(CI),以评估动脉硬化与髋部骨折的关系:我们分析了每组 95 名患者,中位年龄为 82 [79-87] 岁,其中 77.9% 为女性。两组患者的血管疾病发生率均较高(25%),但无差异。与对照组相比,髋部骨折患者有更高的亚临床动脉硬化改变,颈动脉斑块的比例更高(OR 3.25 [1.06-9.97]):结论:与无髋部骨折的老年患者相比,有髋部骨折的老年患者亚临床改变明显增加,但心血管动脉硬化性疾病的发病率并未增加。
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来源期刊
Medicina Clinica
Medicina Clinica 医学-医学:内科
CiteScore
3.10
自引率
5.10%
发文量
295
审稿时长
22 days
期刊介绍: Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.
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