The role of Fusobacterium nucleatum in cancer and its implications for clinical applications.

IF 2.8 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Molecular Oral Microbiology Pub Date : 2024-07-11 DOI:10.1111/omi.12475

Wanyi Luo, Juxi Han, Xian Peng, Xuedong Zhou, Tao Gong, Xin Zheng

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Abstract

Fusobacterium nucleatum, a gram-negative anaerobic bacterium abundantly found in the human oral cavity, is widely recognized as a key pathobiont responsible for the initiation and progression of periodontal diseases due to its remarkable aggregative capabilities. Numerous clinical studies have linked F. nucleatum with unfavorable prognostic outcomes in various malignancies. In further research, scholars have partially elucidated the mechanisms underlying F. nucleatum's impact on various types of cancer, thus gaining a certain comprehension of the role played by F. nucleatum in cancer. In this comprehensive review, we present an in-depth synthesis of the interplay between F. nucleatum and different cancers, focusing on aspects such as tumor initiation, metastasis, chemoresistance, and modulation of the tumor immune microenvironment and immunotherapy. The implications for cancer diagnosis and treatment are also summarized. The objective of this review is to enhance our comprehension of the intricate relationship between F. nucleatum and oncogenic pathogenesis, while emphasizing potential therapeutic strategies.

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核酸镰刀菌在癌症中的作用及其对临床应用的影响。

核团镰刀菌是一种革兰氏阴性厌氧菌，大量存在于人类口腔中，因其显著的聚集能力而被广泛认为是导致牙周疾病发生和发展的关键病原菌。大量临床研究表明，核酸酵母菌与各种恶性肿瘤的不良预后有关。在进一步的研究中，学者们部分阐明了 F. nucleatum 对各种癌症的影响机制，从而对 F. nucleatum 在癌症中扮演的角色有了一定的了解。在这篇综合综述中，我们深入综述了 F. nucleatum 与不同癌症之间的相互作用，重点关注肿瘤的诱发、转移、化疗耐药性以及肿瘤免疫微环境的调节和免疫治疗等方面。此外，还总结了其对癌症诊断和治疗的影响。本综述旨在加深我们对 F. nucleatum 与致癌致病之间错综复杂关系的理解，同时强调潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Oral Microbiology DENTISTRY, ORAL SURGERY & MEDICINE-MICROBIOLOGY

CiteScore

6.50

自引率

5.40%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Oral Microbiology publishes high quality research papers and reviews on fundamental or applied molecular studies of microorganisms of the oral cavity and respiratory tract, host-microbe interactions, cellular microbiology, molecular ecology, and immunological studies of oral and respiratory tract infections. Papers describing work in virology, or in immunology unrelated to microbial colonization or infection, will not be acceptable. Studies of the prevalence of organisms or of antimicrobials agents also are not within the scope of the journal. The journal does not publish Short Communications or Letters to the Editor. Molecular Oral Microbiology is published bimonthly.