Ahmed Ashour , Reham M. Samra , Mohamed Samir Darwish , Noha A. Abou-Zeid , Ahmed A. Zaki
{"title":"Antidiabetic and prebiotic activities of flavonoids from Cyperus conglomeratus rottb","authors":"Ahmed Ashour , Reham M. Samra , Mohamed Samir Darwish , Noha A. Abou-Zeid , Ahmed A. Zaki","doi":"10.1016/j.bse.2024.104867","DOIUrl":null,"url":null,"abstract":"<div><p>One new flavan (1), besides four known flavanones (<strong>2</strong>–<strong>5</strong>), was isolated from the aerial parts of <em>Cyperus conglomeratus</em> Rottb. Their structures were established by spectroscopic methods including one and two-dimensional NMR and high-resolution MS. Their antidiabetic activity was evaluated by measuring the inhibitory effect on α-amylase, α-glucosidase, and glycogen phosphorylase. The prebiotic activity was assessed utilizing two probiotic <em>Lacticaseibacillus</em> strains. The effect of the compounds on the enzyme profile of the tested probiotic strains was also evaluated. The promising activity against the tested enzymes was shown by compounds <strong>2</strong> and <strong>4</strong>. All compounds exhibited an enhancement in alkaline phosphatase activity in the enzyme profile of <em>Lb. rhamnosus</em> and <em>Lb. paracasei</em>. This study demonstrated that the isolated flavonoids could be used as dietary supplements or in the development of functional foods for diabetes and prebiotics.</p></div>","PeriodicalId":8799,"journal":{"name":"Biochemical Systematics and Ecology","volume":"116 ","pages":"Article 104867"},"PeriodicalIF":1.4000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemical Systematics and Ecology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0305197824000851","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
One new flavan (1), besides four known flavanones (2–5), was isolated from the aerial parts of Cyperus conglomeratus Rottb. Their structures were established by spectroscopic methods including one and two-dimensional NMR and high-resolution MS. Their antidiabetic activity was evaluated by measuring the inhibitory effect on α-amylase, α-glucosidase, and glycogen phosphorylase. The prebiotic activity was assessed utilizing two probiotic Lacticaseibacillus strains. The effect of the compounds on the enzyme profile of the tested probiotic strains was also evaluated. The promising activity against the tested enzymes was shown by compounds 2 and 4. All compounds exhibited an enhancement in alkaline phosphatase activity in the enzyme profile of Lb. rhamnosus and Lb. paracasei. This study demonstrated that the isolated flavonoids could be used as dietary supplements or in the development of functional foods for diabetes and prebiotics.
期刊介绍：
Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology).
In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
