Encapsulation of propranolol hydrochloride drug using nanoliposome coatings

Abstract

This study investigated the encapsulation of propranolol hydrochloride drug using nanoliposome coatings prepared by a magnetic stirring method. The encapsulation efficiency was determined using a UV–vis spectrophotometer, and the morphology of the propranolol-loaded liposomes was examined by electron microscopy. The results showed that propranolol hydrochloride can be effectively encapsulated in liposomes with a capsule percentage exceeding 70 %. The composition of the lipids used in the liposome structure played a crucial role in the solubility of the encapsulated drug. The relatively good solubility of propranolol allowed for its better entrapment within the aqueous part of the liposomes. The encapsulation of propranolol hydrochloride within liposomal coatings is expected to improve the stability of the drug in the body and significantly reduce its release until it reaches the target organ. The prepared liposomes exhibited a particle diameter between 20 and 100 nm, making them suitable for intravenous drug delivery. The findings suggest that nanoliposome coatings are a promising strategy for the controlled delivery of propranolol hydrochloride.