Morteza Aramesh, Di Yu, Magnus Essand, Cecilia Persson
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Abstract
Nanotopography-Induced Macropinocytosis
In article number 2400487, Morteza Aramesh and co-workers investigate how nanotopographical cues from nanoporous surfaces impact the uptake efficiency by cells. The results demonstrate notable enhancements in cellular uptake efficiency across a range of vectors when cells are exposed to nanoporous surfaces. The uptake process is found to be dependent on the size and morphology of the nanopores, reaching a peak efficacy with blind pores of 400 nm in size. Enhanced genetic transduction on nanoporous surfaces are observed for multiple vectors, including lentiviruses, baculoviruses, and mRNA molecules.
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