Optical microscopy and transcriptomics reveal the origins of fluorescence in glioma surgery

IF 26.8 1区 医学 Q1 ENGINEERING, BIOMEDICAL Nature Biomedical Engineering Pub Date : 2024-07-11 DOI:10.1038/s41551-024-01218-2
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Abstract

Fluorescence guidance is utilized to increase the chances of complete tumour resection while balancing preservation of neurological function in glioma surgery. A multimodal optical microscope capable of imaging the histology and fluorescence of fresh human brain specimens revealed an unexpected pattern of fluorophore accumulation and a new means of visualizing macrophages during surgery.

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光学显微镜和转录组学揭示胶质瘤手术荧光的起源
在胶质瘤手术中,利用荧光引导可增加肿瘤完全切除的机会,同时兼顾神经功能的保护。能对新鲜人脑标本的组织学和荧光成像的多模式光学显微镜揭示了一种意想不到的荧光团聚集模式,以及在手术过程中可视化巨噬细胞的新方法。
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来源期刊
Nature Biomedical Engineering
Nature Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
45.30
自引率
1.10%
发文量
138
期刊介绍: Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.
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