Noneffectiveness of cryostorage duration on clinical and neonatal outcomes after single vitrified-warmed blastocyst transfers

IF 1.6 Q4 REPRODUCTIVE BIOLOGY Middle East Fertility Society Journal Pub Date : 2024-07-11 DOI:10.1186/s43043-024-00196-4
Mungunshagai Baatarsuren, Jambaldorj Jamiyansuren, Chinzorig Ganbaatar, Davaakhuu Sengebaljir, Belguune Erdenekhuyag, Sandag Enkhbaatar, Namsrai Mungunsuvd, Lkhagvasuren Baljinnyam, Ganjiguur Tumur-Ochir, Ariunaa Amarsaikhan, Amarjargal Dorjpurev, Gereltsetseg Ganbat, Tsogzolmaa Boris, Azjargal Khangarid
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Abstract

In the current era of assisted reproductive technology, the strategy of single vitrified-warmed blastocyst transfer (SVBT) is acknowledged for positively impacting clinical outcomes and preventing the risk of multiple conceptions. Previous studies have indicated that blastocyst grade and the day of blastocyst positively correlate with outcomes. Moreover, storage duration has no significant effect on survival rates, clinical outcomes, and neonatal outcomes. However, some researchers express controversial opinions on cryostorage duration, and their findings suggest a negative impact on clinical outcomes. These results remain subject to controversy, and limited studies exist regarding the outcomes after SVBT. Therefore, our study aims to investigate the impact of the day of blastocyst, blastocyst grade, and blastocyst cryostorage duration on clinical and neonatal outcomes following SVBT in patients who underwent clomiphene-citrate-based minimal stimulation. In this study, retrospective cohort study data collected from June 2015 to April 2023 included 2107 patients with first SVBT cycles who underwent a clomiphene-based minimal ovarian stimulation protocol or a drug-free natural protocol at the Ojinmed IVF Center. Patients were categorized into four groups based on blastocyst cryostorage duration: group 1 (< 2 months, n = 882), group 2 (3–6 months, n = 794), group 3 (7–12 months, n = 187), group 4 (13–24 months, n = 126), and group 5 (25–81 months, n = 118). The patient’s clinical and neonatal outcomes were compared with cryostorage duration after the propensity score matched. Multivariable logistic regression analysis revealed that prolonged cryostorage duration insignificantly correlated with clinical outcomes. Additionally, neonatal outcomes are not correlated with cryostorage duration. The patient must consider several parameters when selecting embryos for transfer, including the duration of cryostorage. Our study results show that for the first single vitrified-warmed blastocyst transfer of patients who underwent clomiphene citrate-based minimal stimulation, cryostorage duration does not affect outcomes.
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单次玻璃化温育囊胚移植后,低温贮藏时间对临床和新生儿预后无影响
在当前的辅助生殖技术时代,单次玻璃化温化囊胚移植(SVBT)策略因其对临床结果和预防多胎妊娠风险产生积极影响而得到认可。以往的研究表明,囊胚等级和囊胚日与结果呈正相关。此外,储存时间长短对存活率、临床结果和新生儿结果没有明显影响。然而,一些研究人员对冷冻储存时间的长短提出了有争议的观点,他们的研究结果表明冷冻储存时间对临床结果有负面影响。这些结果仍存在争议,而关于 SVBT 后预后的研究也很有限。因此,我们的研究旨在调查囊胚日、囊胚等级和囊胚冷冻贮存时间对接受枸橼酸氯米芬最小刺激的 SVBT 患者的临床和新生儿预后的影响。在这项研究中,从2015年6月至2023年4月收集的回顾性队列研究数据纳入了2107名在奥津美德试管婴儿中心接受基于克罗米芬的最小卵巢刺激方案或无药物自然方案的首次SVBT周期患者。根据囊胚冷冻储存时间将患者分为四组:第一组(< 2 个月,n = 882)、第二组(3-6 个月,n = 794)、第三组(7-12 个月,n = 187)、第四组(13-24 个月,n = 126)和第五组(25-81 个月,n = 118)。经过倾向评分匹配后,患者的临床和新生儿预后与低温贮藏时间进行了比较。多变量逻辑回归分析显示,低温贮存时间延长与临床预后的相关性不明显。此外,新生儿预后与低温贮存时间也没有相关性。患者在选择胚胎移植时必须考虑多个参数,包括冷冻储存时间。我们的研究结果表明,对于接受枸橼酸氯米芬最小刺激的患者的首次单一玻璃化温热囊胚移植,冷冻贮藏时间长短不会影响结果。
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来源期刊
CiteScore
2.80
自引率
0.00%
发文量
32
审稿时长
45 weeks
期刊最新文献
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