A crosstalk-free dual-mode sweat sensing system for naked-eye sweat loss quantification via changes in structural reflectance

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL Bio-Design and Manufacturing Pub Date : 2024-07-11 DOI:10.1007/s42242-024-00294-2
Bowen Zhong, Hao Xu, Xiaokun Qin, Lingchen Liu, Hailong Wang, Lili Wang
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Abstract

Sweat loss monitoring is important for understanding the body’s thermoregulation and hydration status, as well as for comprehensive sweat analysis. Despite recent advances, developing a low-cost, scalable, and universal method for the fabrication of colorimetric microfluidics designed for sweat loss monitoring remains challenging. In this study, we propose a novel laser-engraved surface roughening strategy for various flexible substrates. This process permits the construction of microchannels that show distinct structural reflectance changes before and after sweat filling. By leveraging these unique optical properties, we have developed a fully laser-engraved microfluidic device for the quantification of naked-eye sweat loss. This sweat loss sensor is capable of a volume resolution of 0.5 μL and a total volume capacity of 11 μL, and can be customized to meet different performance requirements. Moreover, we report the development of a crosstalk-free dual-mode sweat microfluidic system that integrates an Ag/AgCl chloride sensor and a matching wireless measurement flexible printed circuit board. This integrated system enables the real-time monitoring of colorimetric sweat loss signals and potential ion concentration signals without crosstalk. Finally, we demonstrate the potential practical use of this microfluidic sweat loss sensor and its integrated system for sports medicine via on-body studies.

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无串扰双模汗液传感系统,通过结构反射率的变化进行裸眼汗液损失量化
失汗监测对于了解人体的体温调节和水合状态以及进行全面的汗液分析非常重要。尽管最近取得了一些进展,但开发一种低成本、可扩展和通用的方法来制造用于汗液流失监测的比色微流控芯片仍具有挑战性。在本研究中,我们提出了一种适用于各种柔性基底的新型激光雕刻表面粗化策略。该工艺可构建微通道,使其在汗液填充前后显示出明显的结构反射率变化。利用这些独特的光学特性,我们开发出了一种全激光雕刻微流控装置,用于量化肉眼汗液流失量。这种汗液流失传感器的体积分辨率为 0.5 μL,总容量为 11 μL,可根据不同的性能要求进行定制。此外,我们还报告了无串扰双模式汗液微流控系统的开发情况,该系统集成了银/氯化银氯化物传感器和配套的无线测量柔性印刷电路板。该集成系统可实时监测比色法汗液流失信号和电位离子浓度信号,而不会产生串扰。最后,我们展示了这种微流控汗液流失传感器及其集成系统在运动医学中的实际应用潜力。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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