T Cells Immune Imbalance Present in Patients With Multiple Intracranial Aneurysms.

IF 3.4 3区 医学 Q3 IMMUNOLOGY Clinical and experimental immunology Pub Date : 2024-07-11 DOI:10.1093/cei/uxae058
Chuming Tao, Chenglong Liu, Peicong Ge, Liujia Chan, Yuheng Pang, Junsheng Li, Qiheng He, Wei Liu, Siqi Mou, Zhiyao Zheng, Bojian Zhang, Zhikang Zhao, Wei Sun, Qian Zhang, Rong Wang, Yan Zhang, Wenjing Wang, Dong Zhang, Jizong Zhao
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Abstract

Growing evidence suggests that systemic immune and inflammatory responses may play a critical role in the formation and development of aneurysms. Exploring the differences between single intracranial aneurysm (SIA) and multiple IAs (MIAs) could provide insights for targeted therapies. However, there is a lack of comprehensive and detailed characterization of changes in circulating immune cells in MIAs. Peripheral blood mononuclear cell (PBMC) samples from patients with SIA (n = 16) or MIAs (n = 6) were analyzed using high-dimensional mass cytometry to evaluate the frequency and phenotype of immune cell subtypes. A total of 25 cell clusters were identified, revealing that the immune signature of MIAs included cluster changes. Compared to patients with SIA, patients with MIAs exhibited immune dysfunction and regulatory imbalance in T-cell clusters. They also had reduced numbers of CD8+ T cells and their subgroups CD8+ Te and CD8+ Tem cells, as well as reduced numbers of the CD4+ T-cell subgroup CD27-CD4+ Tem cells. Furthermore, compared to SIA, MIAs were associated with enhanced T-cell immune activation, with elevated expression levels of CD3, CD25, CD27, CCR7, GP130, and interleukin 10. This study provides insights into the circulating immune cell profiles in patients with MIAs, highlighting the similarities and differences between patients with SIA and those with MIAs. Furthermore, the study suggests that circulating immune dysfunction may contribute to development of MIAs.

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多发性颅内动脉瘤患者的 T 细胞免疫失衡。
越来越多的证据表明,全身免疫和炎症反应可能在动脉瘤的形成和发展中起着至关重要的作用。探索单发颅内动脉瘤(SIA)和多发动脉瘤(MIA)之间的差异可为靶向治疗提供启示。然而,目前还缺乏对多发性动脉瘤中循环免疫细胞变化的全面而详细的描述。研究人员使用高维质谱仪分析了SIA(16例)或MIA(6例)患者的外周血单核细胞(PBMC)样本,以评估免疫细胞亚型的频率和表型。共鉴定出 25 个细胞集群,揭示出 MIAs 的免疫特征包括集群变化。与SIA患者相比,MIA患者表现出免疫功能紊乱和T细胞群调节失衡。他们的CD8+ T细胞及其亚群CD8+ Te和CD8+ Tem细胞数量减少,CD4+ T细胞亚群CD27-CD4+ Tem细胞数量减少。此外,与 SIA 相比,MIA 与 T 细胞免疫活化增强有关,CD3、CD25、CD27、CCR7、GP130 和白细胞介素 10 的表达水平升高。这项研究深入揭示了多发性骨髓瘤患者的循环免疫细胞特征,强调了SIA患者与多发性骨髓瘤患者之间的异同。此外,该研究还表明,循环免疫功能失调可能会导致 MIAs 的发生。
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来源期刊
CiteScore
8.40
自引率
2.20%
发文量
101
审稿时长
3-8 weeks
期刊介绍: Clinical & Experimental Immunology (established in 1966) is an authoritative international journal publishing high-quality research studies in translational and clinical immunology that have the potential to transform our understanding of the immunopathology of human disease and/or change clinical practice. The journal is focused on translational and clinical immunology and is among the foremost journals in this field, attracting high-quality papers from across the world. Translation is viewed as a process of applying ideas, insights and discoveries generated through scientific studies to the treatment, prevention or diagnosis of human disease. Clinical immunology has evolved as a field to encompass the application of state-of-the-art technologies such as next-generation sequencing, metagenomics and high-dimensional phenotyping to understand mechanisms that govern the outcomes of clinical trials.
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