{"title":"Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling","authors":"","doi":"10.1038/s41593-024-01725-0","DOIUrl":null,"url":null,"abstract":"Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cerebellar Purkinje neurons to enhance thirst and maintain fluid homeostasis. Surprisingly, this has no effect whatsoever on Purkinje neuron-mediated motor coordination and learning.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41593-024-01725-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cerebellar Purkinje neurons to enhance thirst and maintain fluid homeostasis. Surprisingly, this has no effect whatsoever on Purkinje neuron-mediated motor coordination and learning.
期刊介绍：
Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority.
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In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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