Greater baseline intra-individual variation in telephone-based cognitive screening predicts cognitive and diagnostic outcomes at 2-year follow-up.

IF 2.6 3区 心理学 Q3 NEUROSCIENCES Neuropsychology Pub Date : 2024-09-01 Epub Date: 2024-07-11 DOI:10.1037/neu0000959
Shayne S-H Lin, Rebecca S Allen
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Abstract

Objective: Intra-Individual Cognitive Variability (IICV) is an emerging clinical tool that has shown promise in predicting cognitive decline and dementia incidence. The present study aims to assess the predictive validity of IICV in remote cognitive screening tests, using nationally representative data.

Method: Two waves of cognitive and diagnostic data from the Health and Retirement Study (collected in 2010 and 2012) were utilized to investigate whether baseline IICV can predict cognitive decline and dementia pathology. Middle-aged and older adults who were cognitively intact and completed all cognitive tests at both baseline and follow-up were recruited in the study, resulting in a sample of 6,050 participants. With the coefficient of variation method, the IICV-dispersion was calculated based on cognitive screeners to predict follow-up mean cognitive performance, global cognition, suspected cognitive impairment, and self-reported dementia diagnosis.

Results: After accounting for demographics, depressive symptoms, and baseline cognitive performance, the results provide support for the predictive validity of IICV. Specifically, the study demonstrated that IICV-dispersion significantly predicted cognitive and diagnostic outcomes in a concave pattern where the prediction was more sensitive toward the higher end of IICV. IICV explained about 0.2%-2.3% of the variance of outcomes variables.

Conclusions: IICV retrieved from cognitive screening tests in telemedicine settings offers insight into future cognitive functioning and neurocognitive diagnostic status, which can be cost-effective and reduce the burden on both patients and health care providers, especially benefitting individuals with low socioeconomic status and rural residents. Potential avenues for future research were also discussed. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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基于电话的认知筛查中更大的基线个体内差异可预测 2 年随访的认知和诊断结果。
目的:个体认知变异性(IICV)是一种新兴的临床工具,在预测认知能力下降和痴呆症发病率方面显示出良好的前景。本研究旨在利用具有全国代表性的数据,评估 IICV 在远程认知筛查测试中的预测有效性:方法:利用 "健康与退休研究"(Health and Retirement Study)的两波认知和诊断数据(收集于 2010 年和 2012 年),研究基线 IICV 是否能预测认知功能衰退和痴呆症病理。研究招募了认知功能完好、在基线和随访期间完成所有认知测试的中老年人,共获得 6050 个样本。采用变异系数法,根据认知筛查结果计算了IICV-分散度,以预测后续平均认知表现、总体认知、疑似认知障碍和自我报告的痴呆诊断:在考虑了人口统计学、抑郁症状和基线认知表现后,研究结果为 IICV 的预测有效性提供了支持。具体来说,研究表明,IICV-离散度可以显著预测认知和诊断结果,其预测结果呈凹形,IICV越高,预测结果越敏感。IICV解释了约0.2%-2.3%的结果变量变异:从远程医疗环境下的认知筛查测试中获取的 IICV 可以帮助人们了解未来的认知功能和神经认知诊断状况,这不仅具有成本效益,还能减轻患者和医疗服务提供者的负担,尤其有利于社会经济地位较低的人群和农村居民。会议还讨论了未来研究的潜在途径。(PsycInfo Database Record (c) 2024 APA, 版权所有)。
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来源期刊
Neuropsychology
Neuropsychology 医学-神经科学
CiteScore
4.10
自引率
4.20%
发文量
132
审稿时长
6-12 weeks
期刊介绍: Neuropsychology publishes original, empirical research; systematic reviews and meta-analyses; and theoretical articles on the relation between brain and human cognitive, emotional, and behavioral function.
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