Intrinsic capacity decline as a predictor of functional disability in the elderly: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY Archives of gerontology and geriatrics Pub Date : 2024-06-26 DOI:10.1016/j.archger.2024.105550

Xuedan Wang , Tingting Yang , Yidan Li , Chi Ma , Mengyu Yang , Qiuxia Qian , Guifen Ma , Hongbo Pei , Juanjuan Feng , Fanghong Yan , Xiangping Fan , Jianxun Cao , Yuxia Ma

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Abstract

Objectives

To examine the predictive value of intrinsic capacity decline on functional disability among the elderly.

Design

Meta-analysis.

Methods

PubMed, EMBASE, Web of Science, The Cochrane Library, Wanfang Database, China Knowledge Resource Integrated Database (CNKI), Weipu Database (VIP), and Chinese Biomedical Database (CBM) were searched for relevant studies published from the inception until June 1, 2024. Stata 17.0 software was used to perform the meta-analysis. The methodological quality was evaluated using the Newcastle Ottawa Scale. The overall quality of evidence used GRADE guidelines to assess. A study protocol was registered in PROSPERO (CRD42023475461).

Results

The meta-analysis included 8 cohort studies including 9744 elderly people. Functional disability including ADL disability (n = 6) and IADL disability (n = 7). The results showed that intrinsic capacity decline could predict ADL disability (HR = 1.08, 95 %CI 1.04–1.12; I² = 98.2 %, P < 0.001) and IADL disability (HR = 1.11, 95 %CI 1.05–1.17; I² = 96.4 %, P < 0.001). The overall risk of bias was low. And the grade of evidence that assessed by GRADE guidelines was rated as moderate.

Conclusions

Intrinsic capacity decline is a predictor of functional disability in the elderly. Therefore, screening intrinsic capacity decline has important clinical implications for early identifying the risk of functional disability, which contributes to providing individualized interventions ahead of potential functional disability for the elderly, thereby preventing functional disability, improving the quality of life and promoting healthy aging.

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内在能力下降是老年人功能性残疾的预测因素：系统回顾和荟萃分析。

目的研究内在能力下降对老年人功能障碍的预测价值：方法： Meta分析：检索PubMed、EMBASE、Web of Science、The Cochrane Library、万方数据库、中国知识资源整合数据库（CNKI）、维普数据库（VIP）和中国生物医学数据库（CBM）中从开始到2024年6月1日发表的相关研究。使用Stata 17.0软件进行荟萃分析。方法学质量采用纽卡斯尔-渥太华量表进行评估。证据的总体质量采用 GRADE 指南进行评估。研究方案已在 PROSPERO（CRD42023475461）上注册：荟萃分析包括 8 项队列研究，涉及 9744 名老年人。功能障碍包括日常活动能力障碍（6 例）和非日常活动能力障碍（7 例）。结果显示，内在能力下降可预测ADL残疾（HR = 1.08, 95 %CI 1.04-1.12; I2 = 98.2 %, P < 0.001）和IADL残疾（HR = 1.11, 95 %CI 1.05-1.17; I2 = 96.4 %, P < 0.001）。总体偏倚风险较低。根据 GRADE 指南评估的证据等级为中等：结论：内在能力下降是预测老年人功能障碍的一个指标。因此，筛查内在能力下降对早期识别功能性残疾风险具有重要的临床意义，有助于在老年人可能出现功能性残疾之前提供个体化干预，从而预防功能性残疾，提高生活质量，促进健康老龄化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of gerontology and geriatrics 医学-老年医学

CiteScore

7.30

自引率

5.00%

发文量

198

审稿时长

16 days

期刊介绍： Archives of Gerontology and Geriatrics provides a medium for the publication of papers from the fields of experimental gerontology and clinical and social geriatrics. The principal aim of the journal is to facilitate the exchange of information between specialists in these three fields of gerontological research. Experimental papers dealing with the basic mechanisms of aging at molecular, cellular, tissue or organ levels will be published. Clinical papers will be accepted if they provide sufficiently new information or are of fundamental importance for the knowledge of human aging. Purely descriptive clinical papers will be accepted only if the results permit further interpretation. Papers dealing with anti-aging pharmacological preparations in humans are welcome. Papers on the social aspects of geriatrics will be accepted if they are of general interest regarding the epidemiology of aging and the efficiency and working methods of the social organizations for the health care of the elderly.