Archives of gerontology and geriatrics最新文献

Protein supplementation alone or combined with exercise for sarcopenia and physical frailty: A systematic review and meta-analysis of randomized controlled trials 单独补充蛋白质或结合运动治疗肌肉疏松症和身体虚弱：随机对照试验的系统回顾和荟萃分析

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-11 DOI: 10.1016/j.archger.2025.105783

Yoshihiro Yoshimura , Ayaka Matsumoto , Tatsuro Inoue , Masatsugu Okamura , Masafumi Kuzuya

Background

Sarcopenia and physical frailty are age-related syndromes characterized by progressive loss of muscle mass and function, significantly impacting mortality and quality of life in older adults. This systematic review evaluated the effectiveness of protein supplementation interventions for these conditions.

Methods

We systematically searched Medline, CENTRAL, and Ichushi Web from January 2000 to March 2023, with additional manual searching extended to March 2024. Randomized controlled trials investigating protein supplementation, alone or combined with exercise, in adults aged ≥65 years with sarcopenia or physical frailty were included. The primary outcomes were changes in muscle mass, strength, and physical performance.

Results

The systematic literature search identified 1,506 records through database searching (Medline: 357, CENTRAL: 275, Ichushi Web: 639) and 235 additional records through hand searching. Finally, 13 randomized controlled trials (n=1,057) met the inclusion criteria. Combined protein and exercise interventions demonstrated significant improvements in skeletal muscle index (MD = 0.89 kg/m², 95 % CI: 0.45 to 1.33) and handgrip strength (MD: +2.64 kg, 95 % CI: +0.75 to +4.53) compared to exercise alone. Protein supplementation alone showed modest benefits in muscle strength but limited effects on physical performance. No serious adverse events were reported.

Conclusions

While protein supplementation combined with exercise shows promising effects on muscle mass and strength in older adults with sarcopenia or physical frailty, the evidence quality was consistently rated as very low. Further high-quality trials are needed to establish optimal supplementation strategies.

Registration

PROSPERO: CRD42023408529

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引用次数: 0

Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-11 DOI: 10.1016/j.archger.2025.105784

Shenbi Yang , Hongyan Wang , Yanmin Tao , Jing Tian , Zhifei Wen , Jun Cao , Wen Zhang , Sihan Peng , Xiangeng Zhang

Purpose

Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.

Methods

A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.

Results

A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; I² = 82 %, p < 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; I² = 98 %, p < 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.

Conclusions

No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.

{"title":"Association of chronic pain with frailty and pre-frailty in older adults: A systematic review and meta-analysis","authors":"Shenbi Yang , Hongyan Wang , Yanmin Tao , Jing Tian , Zhifei Wen , Jun Cao , Wen Zhang , Sihan Peng , Xiangeng Zhang","doi":"10.1016/j.archger.2025.105784","DOIUrl":"10.1016/j.archger.2025.105784","url":null,"abstract":"<div><h3>Purpose</h3><div>Frailty has been demonstrated to correlate with chronic pain (CP). This study aimed to estimate the risk of frailty/pre-frailty and evaluate the potential bidirectional relationship between frailty/pre-frailty and CP.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across ten databases, covering literature from their inception through November 23, 2024. Two independent reviewers screened relevant studies, assessed study quality, and extracted data. All analyses were performed using R software, version 4.3.1.</div></div><div><h3>Results</h3><div>A total of 25,904 participants aged ≥ 60 years were included in 33 studies. CP significantly increased the risk of frailty (OR = 1.91, 95 % CI: 1.47–2.47; <em>I<sup>2</sup></em> = 82 %, <em>p</em> < 0.01), whereas no significant association was found between frailty/pre-frailty and CP risk (OR = 1.52, 95 % CI: 0.66–3.50; <em>I<sup>2</sup></em> = 98 %, <em>p</em> < 0.01). Eleven studies were classified as high quality, and the remainder as moderate quality.</div></div><div><h3>Conclusions</h3><div>No evidence supports a bidirectional relationship between frailty/pre-frailty and CP. Nonetheless, addressing and managing CP in older adults may mitigate the risk of frailty and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105784"},"PeriodicalIF":3.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A structural equation modeling approach to investigating the influence of smart kitchen appliance design features on older adults' technology acceptance

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-10 DOI: 10.1016/j.archger.2025.105781

Yongchuan Li , Cuiping Jiang , Salwa Hanim Abdul-Rashid , Raja Ariffin Raja Ghazilla , Jing Jin

This study investigates the influence of smart kitchen appliance design features on older adults' technology acceptance in China using the Smart Kitchen Appliance–Senior Technology Acceptance Model (SKA–STAM). The SKA–STAM extends the Technology Acceptance Model (TAM) with five key design elements: ergonomics, visuals, functions, interactive interfaces, and brands. A cross-sectional survey using a structured questionnaire was administered to 352 Chinese older adults aged 65–84 in first- and second-tier cities from August to October 2024. Participants were recruited through convenience sampling in residential areas, parks, and fitness spaces in Shanghai and Nanjing, and online random sampling in other cities. Structural equation modeling (SEM) was used to analyze the relationships between design elements, older adults' perceptions, and behavioral intention. The results support the significant role of ergonomics, functions, interactive interfaces, and brands in shaping older users' perceived usefulness, ease of use, and enjoyment. Perceived ease of use emerged as a critical mediator linking design elements to usefulness and enjoyment perceptions. The findings contribute to the theoretical understanding of technology acceptance among older adults and provide practical insights for designing senior-friendly smart kitchen appliances.

{"title":"A structural equation modeling approach to investigating the influence of smart kitchen appliance design features on older adults' technology acceptance","authors":"Yongchuan Li , Cuiping Jiang , Salwa Hanim Abdul-Rashid , Raja Ariffin Raja Ghazilla , Jing Jin","doi":"10.1016/j.archger.2025.105781","DOIUrl":"10.1016/j.archger.2025.105781","url":null,"abstract":"<div><div>This study investigates the influence of smart kitchen appliance design features on older adults' technology acceptance in China using the Smart Kitchen Appliance–Senior Technology Acceptance Model (SKA–STAM). The SKA–STAM extends the Technology Acceptance Model (TAM) with five key design elements: ergonomics, visuals, functions, interactive interfaces, and brands. A cross-sectional survey using a structured questionnaire was administered to 352 Chinese older adults aged 65–84 in first- and second-tier cities from August to October 2024. Participants were recruited through convenience sampling in residential areas, parks, and fitness spaces in Shanghai and Nanjing, and online random sampling in other cities. Structural equation modeling (SEM) was used to analyze the relationships between design elements, older adults' perceptions, and behavioral intention. The results support the significant role of ergonomics, functions, interactive interfaces, and brands in shaping older users' perceived usefulness, ease of use, and enjoyment. Perceived ease of use emerged as a critical mediator linking design elements to usefulness and enjoyment perceptions. The findings contribute to the theoretical understanding of technology acceptance among older adults and provide practical insights for designing senior-friendly smart kitchen appliances.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105781"},"PeriodicalIF":3.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of childhood and adulthood socioeconomic status with frailty index trajectories: Using five-wave panel data from the China Health and Retirement Longitudinal Study (CHARLS)

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-08 DOI: 10.1016/j.archger.2025.105780

Kai Zhang, Lirong Chai, Yi Zhang, Weijing Wang, Xiaolin Hu, Weizheng Kong, Dongfeng Zhang, Junning Fan

Background

The relationship between childhood and adulthood socioeconomic status (SES) and long-term frailty trajectories is unclear. We aimed to assess the frailty index (FI) dynamic trajectories and examine the associations between childhood and adulthood SES and frailty trajectories.

Methods

We included 7321 participants aged 45 and older from the 2011–2020 China Health and Retirement Longitudinal Study (CHARLS). Six childhood SES factors and four adulthood SES factors were included. Group-based trajectory modelling was used to identify frailty trajectories and multinomial logistic regression was used to assess the association between SES and frailty trajectories.

Results

Three frailty trajectory groups were identified: low-increase trajectory (LT, 59.9 %), moderate-increase trajectory (MT, 31.7 %) and high-increase trajectory (HT, 8.4 %). With the LT group as reference, for childhood SES, participants with an illiterate mother (relative-risk radio [RRR]=1.67, 95 % confidence interval [CI]: 1.10–2.52), having not enough food (1.67, 1.34–2.09), with family's financial situation (2.35, 1.61–3.42) and childhood health status (2.72, 2.09–3.53) worse than others had higher odds of being in the HT group. For adulthood SES, rural residence (1.86, 1.50–2.31), with an educational level of less than middle school (2.75, 1.83–4.15), had higher odds of being in the HT group. Similar results were found for people of different ages, genders, and residences.

Conclusions

Participants with lower SES, including maternal and self- low education, childhood hunger, worse family financial and childhood health status are more likely to experience a high-increase FI trajectory, i.e. aging faster. Attention should be paid to reduce early-life social inequalities thus to promote later-time healthy aging.

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引用次数: 0

Which pathway of the possible sarcopenia algorithm of the AWGS 2019 guideline is the best in Korean community-dwelling older men and women?

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-05 DOI: 10.1016/j.archger.2025.105778

Sohee Kim , Hyung Eun Shin , Miji Kim , Chang Won Won

Objective

To compare the diagnostic accuracy of possible sarcopenia identification pathways, as suggested by Asian Working Group for Sarcopenia (AWGS) in 2019, by gender among Korean community-dwelling older adults.

Design

Cross-sectional analysis of data from 2,129 community-dwelling adults (70–84 years, 50.4% men) enrolled in Korean Frailty and Aging Cohort Study.

Methods

Based on AWGS 2019 guideline, possible sarcopenia was defined by low handgrip strength (HGS) or slow five-times chair stand test (5CST) time, referred to as “assessments.” “Case-findings” (low calf circumference [CC], SARC-F ≥4, or SARC-CalF ≥11) were recommended for screening ‘possible sarcopenia’ before assessment. For the six ‘possible sarcopenia’ pathways (combining three case-finding and two assessment tools), area under the curve (AUC) and F₁ score are compared.

Results

For case-finding in men, CC demonstrated the highest AUC (0.657) and F₁ score (0.504) for predicting sarcopenia compared with SARC-F and SARC-CalF (p <0.001, =0.001). Among men with low CC, ΔAUC between HGS and 5CST was not significant as assessment (p=0.079) (AUCs: 0.763 vs. 0.707; F₁ scores: 0.713 vs. 0.650). For case-finding in women, SARC-CalF demonstrated the highest AUC (0.631) and F₁ score (0.389) compared with CC and SARC-F (p=0.012, <0.001). Subsequently, ΔAUC between HGS and 5CST was not significant in women (p=0.069) (AUCs: 0.566 vs. 0.636; F₁ scores: 0.387 vs. 0.514).

Conclusions

Based on AWGS 2019 guideline, CC in men and SARC-CalF in women was the best case-finding tool for community-dwelling older adults. After the best case-finding in each gender, two assessment pathways demonstrated insignificant difference in both genders.

Brief summary

For case-finding of possible sarcopenia, using calf circumference in older men and using SARC-CalF in older women demonstrated the highest diagnostic accuracy for predicting sarcopenia. After the best case-finding in each gender, two assessment pathways (handgrip strength and five-times chair stand test) of possible sarcopenia demonstrated insignificant difference in both genders.

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引用次数: 0

Effects of dance interventions on cognitive function, balance, mobility, and life quality in older adults: A systematic review and Bayesian network meta-analysis

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-04 DOI: 10.1016/j.archger.2025.105775

Hongli Zhang, Yilun Gao, Yuexin Zhang, Hongtao Ma

Background

Physical inactivity in older adults is strongly associated with a variety of health problems that may lead to cognitive decline and impaired physical and mental health. The aim of this study was to investigate the effectiveness of five different dances on cognitive function and quality of life in older adults.

Methods

seven databases were systematically searched. Two reviewers independently completed the screening, quality assessment and data extraction of the study. Standardized mean differences (SMDs) were calculated using the Network package in Stata software and network meta-analyses (NMAs) were conducted using Bayesian consistency models using the GeMTC package in R software.

Results

The NMA consisted of 28 studies involving 1967 older adults aged 60 years or older, focusing on five different types of dance interventions. The results of the NMA showed that only ballroom dancing significantly improved cognitive function (SMD = 0.89, 95 % confidence interval [CI] (0.07, 1.70)), whereas tango and folk dancing significantly improved balance (SMD = 1. 62, 95 % CI (0.50, 2.76), (SMD = 1.43, 95 % CI (0.15, 2.81)), while tango and self-created dance enhanced mobility (SMD = -1.42, 95 % CI (-2.60, -0.25), (SMD = -1.20, 95 % CI (-2.10, -0.37)). Furthermore, square dancing was the only intervention that significantly improved mental health (SMD = 1.11, 95 % CI (0.03, 2.31)).

Conclusion

Ballroom dancing and square dancing appear to be the most effective interventions for improving cognitive ability and mental health, respectively, while tango shows promise as an intervention for improving balance and mobility.

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引用次数: 0

Differing risk factors for potentially preventable and fall-related injury readmissions of older residents in long-term care facilities after hip fracture 髋部骨折后长期护理机构中的老年住院者因潜在的可预防和跌倒相关伤害而再次入院的不同风险因素

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-04 DOI: 10.1016/j.archger.2025.105779

Seigo Mitsutake , Reidar P. Lystad , Tolesa Okuba , Janet C. Long , Jeffrey Braithwaite , Takumi Hirata , Rebecca Mitchell

Background

Although most fall-related injury readmissions are preventable, there may be differences between risk factors for other potentially preventable readmissions (PPR) and fall-related injury readmissions. This study examined the differences between risk factors for 30-day PPR and fall-related injury readmissions among older adults living in residential aged care facilities (RACFs) after a hip fracture.

Methods

This retrospective cohort study used linked hospitalization and mortality data in New South Wales, Australia. Residents aged ≥65 years who live in RACFs and were admitted after a hip fracture between 2014 and 2023. Demographic data, the number of Charlson comorbidities, and frailty risk were used. The 30-day PPR was identified using 22 conditions as defined by the Australian government, and three additional conditions (pressure injury, dehydration, sepsis). Multivariable logistic regression examined the predictors for 30-day PPR and fall-related injury readmissions.

Results

Among 12,335 residents, there were 266 residents who experienced PPR, and 361 residents who experienced fall-related injury readmissions. Although residents with one (odds ratios: 1.98, 95 % confidence interval: 1.50–2.61) or ≥2 comorbidities (2.38, 1.67–3.37) had a higher risk of 30-day PPR than residents without comorbidities, there was no association of comorbidities with 30-day fall-related injury readmissions. Frailty risk was not associated with 30-day PPR, but residents with high (0.58, 0.37–0.92) and moderate frailty risk (0.63, 0.40–0.99) were less likely to experience fall-related injury readmissions than residents with no frailty risk.

Conclusions

Targeted approaches for 30-day PPR and fall-related injury readmissions should be optimized based on their specific predictors for preventing 30-day readmissions.

{"title":"Differing risk factors for potentially preventable and fall-related injury readmissions of older residents in long-term care facilities after hip fracture","authors":"Seigo Mitsutake , Reidar P. Lystad , Tolesa Okuba , Janet C. Long , Jeffrey Braithwaite , Takumi Hirata , Rebecca Mitchell","doi":"10.1016/j.archger.2025.105779","DOIUrl":"10.1016/j.archger.2025.105779","url":null,"abstract":"<div><h3>Background</h3><div>Although most fall-related injury readmissions are preventable, there may be differences between risk factors for other potentially preventable readmissions (PPR) and fall-related injury readmissions. This study examined the differences between risk factors for 30-day PPR and fall-related injury readmissions among older adults living in residential aged care facilities (RACFs) after a hip fracture.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used linked hospitalization and mortality data in New South Wales, Australia. Residents aged ≥65 years who live in RACFs and were admitted after a hip fracture between 2014 and 2023. Demographic data, the number of Charlson comorbidities, and frailty risk were used. The 30-day PPR was identified using 22 conditions as defined by the Australian government, and three additional conditions (pressure injury, dehydration, sepsis). Multivariable logistic regression examined the predictors for 30-day PPR and fall-related injury readmissions.</div></div><div><h3>Results</h3><div>Among 12,335 residents, there were 266 residents who experienced PPR, and 361 residents who experienced fall-related injury readmissions. Although residents with one (odds ratios: 1.98, 95 % confidence interval: 1.50–2.61) or ≥2 comorbidities (2.38, 1.67–3.37) had a higher risk of 30-day PPR than residents without comorbidities, there was no association of comorbidities with 30-day fall-related injury readmissions. Frailty risk was not associated with 30-day PPR, but residents with high (0.58, 0.37–0.92) and moderate frailty risk (0.63, 0.40–0.99) were less likely to experience fall-related injury readmissions than residents with no frailty risk.</div></div><div><h3>Conclusions</h3><div>Targeted approaches for 30-day PPR and fall-related injury readmissions should be optimized based on their specific predictors for preventing 30-day readmissions.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105779"},"PeriodicalIF":3.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ikigai is associated with lower incidence of frailty during a 5-year follow-up in older women: The possible role of interleukin-6

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-03 DOI: 10.1016/j.archger.2025.105776

Bo-Kyung Son , Michiko Nanao-Hamai , Yumi Umeda-Kameyama , Weida Lyu , Tomoki Tanaka , Yasuyo Yoshizawa , Masahiro Akishita , Katsuya Iijima

Purpose

Ikigai, a psychological concept in Japanese culture representing a life worth living, contributes to health outcomes. This study examined the association between Ikigai and the incidence of frailty and sought to investigate the underlying biological mechanism by exploring inflammatory cytokines.

Materials and methods

In the 2016 Kashiwa Cohort Study, 832 community-dwelling older adults without frailty were enrolled. Participants reported their Ikigai status at baseline. Frailty was defined as meeting three of Fried's five phenotypic criteria. Plasma concentrations of inflammatory cytokines, including interleukins (ILs) and tumor necrosis factor α, were measured at baseline using immunoassays. Cox regression was used to analyze the association between Ikigai and new-onset frailty stratified by sex after adjusting for relevant confounders.

Results

Overall, 7.1 % of 832 participants (75.8 ± 4.7 years, women 47.0 %) developed new-onset frailty during the 5-year follow-up. Older adults with Ikigai (n = 749) had better vitality and mental health and fewer depressive symptoms than those without Ikigai. In women, Ikigai was associated with a lower risk of developing frailty (a fully-adjusted hazard ratio=0.24, 95 % confidence interval: 0.08–0.73, P = 0.012). Notably, a significantly lower prevalence of exhaustion was observed in women with Ikigai (P < 0.001). A higher concentration of IL-6 was observed in women with Ikigai at baseline than in those without Ikigai who developed frailty (P = 0.036).

Conclusions

This study demonstrated that Ikigai could prevent frailty in women, which might be attributed to mitigate exhaustion. Furthermore, the biological actions of Ikigai are associated with high IL-6 levels. Our findings suggest that sex-specific frailty prevention should be considered with Ikigai.

{"title":"Ikigai is associated with lower incidence of frailty during a 5-year follow-up in older women: The possible role of interleukin-6","authors":"Bo-Kyung Son , Michiko Nanao-Hamai , Yumi Umeda-Kameyama , Weida Lyu , Tomoki Tanaka , Yasuyo Yoshizawa , Masahiro Akishita , Katsuya Iijima","doi":"10.1016/j.archger.2025.105776","DOIUrl":"10.1016/j.archger.2025.105776","url":null,"abstract":"<div><h3>Purpose</h3><div><em>Ikigai</em>, a psychological concept in Japanese culture representing a life worth living, contributes to health outcomes. This study examined the association between <em>Ikigai</em> and the incidence of frailty and sought to investigate the underlying biological mechanism by exploring inflammatory cytokines.</div></div><div><h3>Materials and methods</h3><div>In the 2016 Kashiwa Cohort Study, 832 community-dwelling older adults without frailty were enrolled. Participants reported their <em>Ikigai</em> status at baseline. Frailty was defined as meeting three of Fried's five phenotypic criteria. Plasma concentrations of inflammatory cytokines, including interleukins (ILs) and tumor necrosis factor α, were measured at baseline using immunoassays. Cox regression was used to analyze the association between <em>Ikigai</em> and new-onset frailty stratified by sex after adjusting for relevant confounders.</div></div><div><h3>Results</h3><div>Overall, 7.1 % of 832 participants (75.8 ± 4.7 years, women 47.0 %) developed new-onset frailty during the 5-year follow-up. Older adults with <em>Ikigai</em> (<em>n</em> = 749) had better vitality and mental health and fewer depressive symptoms than those without <em>Ikigai</em>. In women, <em>Ikigai</em> was associated with a lower risk of developing frailty (a fully-adjusted hazard ratio=0.24, 95 % confidence interval: 0.08–0.73, <em>P</em> = 0.012). Notably, a significantly lower prevalence of exhaustion was observed in women with <em>Ikigai</em> (<em>P</em> < 0.001). A higher concentration of IL-6 was observed in women with <em>Ikigai</em> at baseline than in those without <em>Ikigai</em> who developed frailty (<em>P</em> = 0.036).</div></div><div><h3>Conclusions</h3><div>This study demonstrated that <em>Ikigai</em> could prevent frailty in women, which might be attributed to mitigate exhaustion. Furthermore, the biological actions of <em>Ikigai</em> are associated with high IL-6 levels. Our findings suggest that sex-specific frailty prevention should be considered with <em>Ikigai</em>.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105776"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143355441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear ageing gero-marker dynamics of transcriptomic profile during calcific aortic valve mouse modeling

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-02-03 DOI: 10.1016/j.archger.2025.105777

Hongzheng Li , Xiaoshan Cui , Zucheng Shang , Wenwen Yang , Aimei Lu , Hao Guo , Zhi'ang Cheng , Jiayan Zhou , Yue Wei , Mengfan Li , Guang Chen , Zikai Yu

The prevention and management of degenerative heart disease remain challenging and could potentially be significantly improved by understanding of ageing biomarker dynamics. In this study, we constructed the calcific aortic valve mouse model at different age points, measured valve function degeneration along with valve calcification, and investigated the nonlinear dynamics using sequencing data and deep learning models. In C57BL/6 N mouse model, the older mice had higher levels of peak transvalvular jet velocity in terms of valve function. Regarding valve calcification, collagen and elastic fiber calcification in the middle layer increased significantly at 48-week-old (p < 0.001), and the calcification spread to the inner endothelial cells at 72-week-old (p < 0.0001). RNA sequencing illustrated that 30 genes, including Acadsb, L2hgdh, and Cpped1, showed increased expression with age. Among them, four genes, namely Hipk2, 9430069I07Rik, Peli3, and Slc22a12, increased more than threefold in aortic tissues in 72-week-old mice compared to 6-week-old mice. Moreover, a large proportion of genes changed in a nonlinear pattern (6,325 out of 12,160, 52%). In conclusion, both linear and nonlinear gero-markers were found in the calcific aortic valve mouse modeling, which highlighted specific periods of significant wave with accelerated ageing (48-week-old in mice).

{"title":"Nonlinear ageing gero-marker dynamics of transcriptomic profile during calcific aortic valve mouse modeling","authors":"Hongzheng Li , Xiaoshan Cui , Zucheng Shang , Wenwen Yang , Aimei Lu , Hao Guo , Zhi'ang Cheng , Jiayan Zhou , Yue Wei , Mengfan Li , Guang Chen , Zikai Yu","doi":"10.1016/j.archger.2025.105777","DOIUrl":"10.1016/j.archger.2025.105777","url":null,"abstract":"<div><div>The prevention and management of degenerative heart disease remain challenging and could potentially be significantly improved by understanding of ageing biomarker dynamics. In this study, we constructed the calcific aortic valve mouse model at different age points, measured valve function degeneration along with valve calcification, and investigated the nonlinear dynamics using sequencing data and deep learning models. In C57BL/6 N mouse model, the older mice had higher levels of peak transvalvular jet velocity in terms of valve function. Regarding valve calcification, collagen and elastic fiber calcification in the middle layer increased significantly at 48-week-old (<em>p</em> < 0.001), and the calcification spread to the inner endothelial cells at 72-week-old (<em>p</em> < 0.0001). RNA sequencing illustrated that 30 genes, including <em>Acadsb, L2hgdh</em>, and <em>Cpped1</em>, showed increased expression with age. Among them, four genes, namely <em>Hipk2, 9430069I07Rik, Peli3</em>, and <em>Slc22a12</em>, increased more than threefold in aortic tissues in 72-week-old mice compared to 6-week-old mice. Moreover, a large proportion of genes changed in a nonlinear pattern (6,325 out of 12,160, 52%). In conclusion, both linear and nonlinear gero-markers were found in the calcific aortic valve mouse modeling, which highlighted specific periods of significant wave with accelerated ageing (48-week-old in mice).</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105777"},"PeriodicalIF":3.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: A socio-ecological approach

IF 3.5 3区医学 Q2 GERIATRICS & GERONTOLOGY

Archives of gerontology and geriatrics

Pub Date : 2025-01-27 DOI: 10.1016/j.archger.2025.105772

Ji Hye Shin , Hae Sagong , Ju Young Yoon

Background

Functional ability (FA), a key determinant of healthy aging, is determined by intrinsic capacity (IC), environmental factors, and their interactions. IC is a composite of physical and mental capacities that undergo constant change. Therefore, understanding the factors that influence IC requires a multi-level analysis of individuals to optimize its trajectory.

Methods

Individuals aged ≥ 65 were included in the Korean Longitudinal Study of Aging (2012–2020). Impaired IC (IIC) scores were tracked over eight years using latent class growth modeling to classify trajectory patterns. Determinants were identified through multinomial logistic regression. The relationship between IIC trajectory and FA decline was assessed using Kaplan-Meier analysis and the Cox proportional hazards model.

Results

Of the 7486 subjects, 2268 (mean age 72.26 [SD 5.31] years; female 56.4 %) were included after excluding those who were underage, had lost independence, or were missing baseline data. The IIC trajectories were categorized into four classes: low-persistent (Class 1, 48.46 %); low-increasing (Class 2, 17.46 %); high-decreasing (Class 3, 20.37 %); and high-stable (Class 4, 13.71 %). Over a mean follow-up of 7.21 years, 536 individuals experienced a decline in FA. After adjusting for confounders, the hazard ratios (HRs) were 1.95 (95 % CI 1.51–2.50) for class 2, 1.93 (1.50–2.46) for class 3, and 3.41 (2.64–4.39) for class 4 compared to class 1. Additionally, age, gender, marital status, employment, social participation, and living status had overlapping effects on both IC and FA.

Conclusions

Understanding the heterogeneity of IC, combined with multidomain interventions, can enable FA maintenance and promote healthy aging.

{"title":"The relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: A socio-ecological approach","authors":"Ji Hye Shin , Hae Sagong , Ju Young Yoon","doi":"10.1016/j.archger.2025.105772","DOIUrl":"10.1016/j.archger.2025.105772","url":null,"abstract":"<div><h3>Background</h3><div>Functional ability (FA), a key determinant of healthy aging, is determined by intrinsic capacity (IC), environmental factors, and their interactions. IC is a composite of physical and mental capacities that undergo constant change. Therefore, understanding the factors that influence IC requires a multi-level analysis of individuals to optimize its trajectory.</div></div><div><h3>Methods</h3><div>Individuals aged ≥ 65 were included in the Korean Longitudinal Study of Aging (2012–2020). Impaired IC (IIC) scores were tracked over eight years using latent class growth modeling to classify trajectory patterns. Determinants were identified through multinomial logistic regression. The relationship between IIC trajectory and FA decline was assessed using Kaplan-Meier analysis and the Cox proportional hazards model.</div></div><div><h3>Results</h3><div>Of the 7486 subjects, 2268 (mean age 72.26 [SD 5.31] years; female 56.4 %) were included after excluding those who were underage, had lost independence, or were missing baseline data. The IIC trajectories were categorized into four classes: low-persistent (Class 1, 48.46 %); low-increasing (Class 2, 17.46 %); high-decreasing (Class 3, 20.37 %); and high-stable (Class 4, 13.71 %). Over a mean follow-up of 7.21 years, 536 individuals experienced a decline in FA. After adjusting for confounders, the hazard ratios (HRs) were 1.95 (95 % CI 1.51–2.50) for class 2, 1.93 (1.50–2.46) for class 3, and 3.41 (2.64–4.39) for class 4 compared to class 1. Additionally, age, gender, marital status, employment, social participation, and living status had overlapping effects on both IC and FA.</div></div><div><h3>Conclusions</h3><div>Understanding the heterogeneity of IC, combined with multidomain interventions, can enable FA maintenance and promote healthy aging.</div></div>","PeriodicalId":8306,"journal":{"name":"Archives of gerontology and geriatrics","volume":"131 ","pages":"Article 105772"},"PeriodicalIF":3.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0