Zoonotic assemblages A and B of Giardia duodenalis in Chiroptera from Brazilian Amazon biome

IF 4.1 2区医学 Q1 INFECTIOUS DISEASES One Health Pub Date : 2024-07-04 DOI:10.1016/j.onehlt.2024.100853

Lisiane Lappe dos Reis , Lirna Salvioni Silva de Souza , Fernanda Rodrigues Fonseca , Alessandra Ferreira Dales Nava , Ana Carolina Paulo Vicente

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Abstract

Bats are important reservoirs and spreaders of pathogens. Giardia duodenalis is a globally important protozoan that infects humans and other mammals with considerable public health burden, particularly on the child development. Based on genetic variation and host specificity, G. duodenalis is categorized into eight genotypes/assemblages A-H. Assemblages A and B are widespread globally and are associated with human and animal disease. There is evidence of Giardia in the bat feces from diverse geographic regions, but the G. duodenalis assemblages are unknown, which is a key point for the One Health view. Here, we successfully amplified the BG/GDH/DIS3/HCMP2/HCMP3 targets of G. duodenalis from five bat species captured in the Brazilian Amazon biome revealing the presence of zoonotic G. duodenalis assemblages A and B in the feces of these flying mammals. Our study reveals that bats may play a role in transmission of zoonotic G. duodenalis, at least in this biome.

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巴西亚马逊生物群落中脊索动物体内 A 型和 B 型杜氏贾第虫的人畜共患组合

蝙蝠是病原体的重要贮藏者和传播者。杜氏贾第鞭毛虫是一种全球重要的原生动物，它感染人类和其他哺乳动物，对公共卫生造成相当大的负担，尤其是对儿童的发育。根据基因变异和宿主特异性，十二指肠贾第虫可分为 A-H 八种基因型/组合。A 组和 B 组广泛分布于全球，与人类和动物疾病相关。有证据表明，不同地理区域的蝙蝠粪便中都含有贾第虫，但十二指肠球虫的集合体却不为人知，这是 "一个健康 "观点的关键点。在这里，我们成功地扩增了在巴西亚马逊生物群落中捕获的五种蝙蝠中杜氏贾第鞭毛虫的 BG/GDH/DIS3/HCMP2/HCMP3靶标，揭示了在这些飞行哺乳动物的粪便中存在人畜共患的杜氏贾第鞭毛虫 A 和 B 组合。我们的研究表明，蝙蝠可能在人畜共患的十二指肠球菌的传播中扮演了一个角色，至少在这个生物群落中是如此。

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来源期刊

One Health Medicine-Infectious Diseases

CiteScore

8.10

自引率

4.00%

发文量

审稿时长

18 weeks

期刊介绍： One Health - a Gold Open Access journal. The mission of One Health is to provide a platform for rapid communication of high quality scientific knowledge on inter- and intra-species pathogen transmission, bringing together leading experts in virology, bacteriology, parasitology, mycology, vectors and vector-borne diseases, tropical health, veterinary sciences, pathology, immunology, food safety, mathematical modelling, epidemiology, public health research and emergency preparedness. As a Gold Open Access journal, a fee is payable on acceptance of the paper. Please see the Guide for Authors for more information. Submissions to the following categories are welcome: Virology, Bacteriology, Parasitology, Mycology, Vectors and vector-borne diseases, Co-infections and co-morbidities, Disease spatial surveillance, Modelling, Tropical Health, Discovery, Ecosystem Health, Public Health.