One Health最新文献

{"title":"Re-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case","authors":"Bacary Djilocalisse Sadio ,&nbsp;Dethié Ngom ,&nbsp;Bocar Sow ,&nbsp;Cheikh Tidiane Diagne ,&nbsp;Aboubacry Gaye ,&nbsp;Aliou Khoulé ,&nbsp;Ousseynou Sène ,&nbsp;Elisabeth Faye ,&nbsp;Moufid Mhamadi ,&nbsp;Diogop Camara ,&nbsp;Cherif Nehma Sylla ,&nbsp;Fatoumata Goundo Diaby ,&nbsp;Mahfouz Traoré ,&nbsp;Oumar Ndiaye ,&nbsp;Khalifa Ababacar Mbaye ,&nbsp;Khady Cissé ,&nbsp;Boly Diop ,&nbsp;El Hadji Mamadou Ndiaye ,&nbsp;Yoro Sall ,&nbsp;Alassane Mbengue ,&nbsp;Diawo Diallo","doi":"10.1016/j.onehlt.2025.101040","DOIUrl":"10.1016/j.onehlt.2025.101040","url":null,"abstract":"<div><div>Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis transmitted mainly by ticks. In Senegal, the CCHF virus has been circulating since at least 2003. However, the first symptomatic human case was detected and confirmed only in 2023 in the southeastern part of the country. Following this detection, a survey of humans, animals and ticks was launched to better characterize the ecology of this virus in this area. Human samples were tested by ELISA and RT-PCR. Serum and tick samples collected from cattle, sheep and goats were tested by ELISA and by RT-PCR, respectively. Antibodies against CCHFV were detected in 0.77 % of humans and 14.18 % of animal sera. The highest seroprevalence was observed in cattle (58.3 %), followed by goats (33.33 %) and sheep (8.33 %). The tick infestation rate was higher in cattle (8.2 %) than in sheep (1.2 %), while goats were not infested. <em>Hyalomma rufipes</em> was the first tick found infected in southeastern Senegal with a CCHF viral minimum field infection rate of 13.3 %. Thus, this study enabled us to better understand the mechanisms of CCHFV emergence in southeastern Senegal.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101040"},"PeriodicalIF":4.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and prevalence of avian influenza epidemic in the southwest of Poyang Lake and analysis of the influence of meteorological factors","authors":"Kang Fang ,&nbsp;Xiansheng Ni ,&nbsp;Xi Wang ,&nbsp;Wentao Song ,&nbsp;Zhiqiang Deng ,&nbsp;Zeyu Zhao ,&nbsp;Wei Hua ,&nbsp;Zhizhong Zeng ,&nbsp;Wei Wang ,&nbsp;Qianqian Si ,&nbsp;Jiang Wu ,&nbsp;Bo Zhang ,&nbsp;Ping Zhang ,&nbsp;Hui Li ,&nbsp;Tianmu Chen","doi":"10.1016/j.onehlt.2025.101047","DOIUrl":"10.1016/j.onehlt.2025.101047","url":null,"abstract":"<div><div>Recently, the epidemiological profile of avian influenza has changed dramatically worldwide. Avian influenza sampling and surveillance of wholesale and retail markets in Nanchang, the largest city in the southwestern region of Poyang Lake, have been conducted since 2017. The transmission pattern of avian influenza in this region was comprehensively evaluated in multiple dimensions including time, subtype changes, seasonality and meteorological factors. Samples were tested for avian influenza A virus nucleic acids using real-time reverse transcription polymerase chain reaction, and positive results were typed. Wavelet coherence analysis was used to reveal the time-frequency variation in meteorological factors associated with avian influenza. The random forest algorithm was used to perform a multifactorial analysis of meteorological factors. Results revealed that the highest avian influenza positivity rate of 42.29 % (95 % CI: 41.18–43.41) occurred in summer. Meteorological factors were found to be significantly associated with the avian influenza positivity rate on a periodic basis. Random forest analysis revealed significant heterogeneity between meteorological factors and changes in the positivity rates of different avian influenza subtypes. Pollution concentration significantly affected the positivity rate of different avian influenza subtypes. The effect of temperature on the positivity rate of the H5 and H9 subtypes followed the opposite pattern to that of the non-H5/H7/H9 positivity rate. In winter, positivity rates of the H5 and H9 subtypes were lower and those of the non-H5/H7/H9 samples were higher; the opposite was true in spring. There is a correlation between pollutant concentration and avian influenza positivity rate. Authorities should consider climatic conditions and the level of contaminants in the prevention and control of avian influenza and adopt different preventive and control measures according to the characteristics of the different subtypes. We recommend continued surveillance of avian influenza in the region and the adoption of a ‘one-health’ approach for integrated prevention and control.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101047"},"PeriodicalIF":4.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to selected pathogens in wild mammals from a rescue and rehabilitation center in southern Italy","authors":"A. Minichino ,&nbsp;L. Ciuca ,&nbsp;L. Dipineto ,&nbsp;L. Rinaldi ,&nbsp;S. Montagnaro ,&nbsp;L. Borrelli ,&nbsp;A. Fioretti ,&nbsp;L.M. De Luca Bossa ,&nbsp;G. Garella ,&nbsp;G. Ferrara","doi":"10.1016/j.onehlt.2025.101049","DOIUrl":"10.1016/j.onehlt.2025.101049","url":null,"abstract":"<div><div>Wildlife is at the same time a reservoir and sentinel of numerous infections for humans and domestic animals. For this reason, wildlife rehabilitation centers represent an opportunity to carry out surveillance against the most varied infections. In this work, wild animals (canids, mustelids, erinaceids, and cervids) hospitalized at a first aid center in southern Italy were sampled and tested with multispecies ELISAs and rapid tests against a panel of pathogens, including viruses, bacteria, and parasites. Foxes and wolves were exposed to <em>Brucella canis</em>, <em>Coxiella burnetii</em>, canine coronavirus, and Pseudorabies virus. Furthermore, one and two foxes tested positive for <em>Anaplasma phagocytophilum</em> and <em>Dirofilaria immitis</em>. Although not confirmed by molecular assay, hedgehogs and porcupines tested positive for <em>Dirofilaria immitis</em> antigens. No animals were exposed to <em>Leishmania infantum</em>, <em>Borrelia burgdorferi</em>, <em>Mycobacterium avium</em>, or Schmallenberg viruses. A fox and a roe deer had antibodies against the hepatitis E virus. The overall prevalence of <em>Angiostrongylus vasorum</em> antigen was 25 % (all the positive samples were collected from red foxes). Parasitological analyses showed the positivity of wild animals to <em>Crenosoma</em> spp., <em>Strongyloides</em> spp., <em>Capillaria</em> spp., and <em>Cystoisospora</em> spp. Wild canids also tested positive for <em>Toxocara</em> spp. and <em>Trichuris vulpis</em>. The results of this study have demonstrated not only the circulation of numerous pathogens in the wildlife of southern Italy but also underlined the risk to which the operators of first aid centers are subjected, considering that some of these animals stand periods of rehabilitation even of several months.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101049"},"PeriodicalIF":4.1,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Were young men picking pets over people? Association between social network and pet ownership: A population-based study","authors":"Tingzhong Yang ,&nbsp;Jinsong Chen ,&nbsp;Ying Liu","doi":"10.1016/j.onehlt.2025.101046","DOIUrl":"10.1016/j.onehlt.2025.101046","url":null,"abstract":"<div><div>This population-based cross-sectional study explores the relationship between social network involvement and pet ownership among young men in China. The study found that 24.1 % of families in the sample owned pets. A multilevel logistic regression analysis was conducted to examine the association between social network size and pet ownership. In this analysis, the odds ratio (OR) was used to quantify the strength of the association. The results revealed that the OR for overall social network size and pet ownership were 2.15 for the smallest network group, 1.63 for the middle network group, and 1.69 for the largest network group, compared to the reference group. The structural equation model showed that the overall social network, as well as both lower- and higher-level social networks, not only have a direct influence on pet ownership but also exert indirect effects through marital status or family location, or regional population density. This study provides important insights into pet ownership behavior, highlighting the role of social networks in shaping human-animal interactions and emphasizing the need for a holistic approach to understanding the factors that contribute to pet ownership decisions. The study deals with animal-human health from a fundamental social level and understanding social needs and structures behind people's pet-keeping behavior provides a good basis for further study of health issues in pet-keeping practices.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101046"},"PeriodicalIF":4.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A first insight into the occurrence of Leptospira, Brucella and Coxiella burnetii infections in wild mammals rescued from illegal trade in Ecuador: A proxy for one health conservation policies","authors":"Ariana Rivera ,&nbsp;Marlon Steven Zambrano-Mila ,&nbsp;Solon Alberto Orlando ,&nbsp;Fabiola Jiménez Valenzuela ,&nbsp;Ericka Sanchez ,&nbsp;Joselyn Calderon ,&nbsp;Manuel González ,&nbsp;Angel Sebastian Rodriguez-Pazmiño ,&nbsp;Alfonso Marzal ,&nbsp;Eliana Molineros ,&nbsp;Miguel Angel Garcia-Bereguiain","doi":"10.1016/j.onehlt.2025.101045","DOIUrl":"10.1016/j.onehlt.2025.101045","url":null,"abstract":"<div><div>Illegal wildlife trade is a major concern not only for conservation and animal welfare but also for public health. Human interaction with wild animals increases the risk of zoonotic disease transmission, while exposure of wildlife to humans and domestic animals poses additional threats to biodiversity through the spread of infectious diseases. This issue is particularly critical in tropical, biodiversity-rich countries like Ecuador, often low- and middle-income nations where resources for conservation are limited. In the absence of official data on illegal wildlife trafficking in Ecuador, several non-profit organizations work in collaboration with the Ministry of the Environment to combat this trade and rehabilitate rescued animals, with the ultimate goal of returning them to their natural habitats. In this study, we addressed for the first time in Ecuador the occurrence of three endemic zoonotic pathogens that cause reproductive problems (<em>Leptospira</em> spp.<em>, Brucella</em> spp.<em>,</em> and <em>Coxiella burnetii</em>) in wild mammals. A total number of 28 individuals from 15 different species, including primates and felines, were included. All the animals tested positive for antibodies against <em>Leptospira</em> spp., and a great diversity of antibodies against pathogenic serovars was found. Moreover, 7.4 % CI: (2.0 %–22.6 %) and 3.7 % CI: (0.6 %–17.7 %) of the animals tested were positive for antibodies against <em>C. burnetii</em> and <em>Brucella</em> spp., respectively. Our results show that wild mammals are a reservoir for leptospirosis in Ecuador. Also, there is a risk of transmission of <em>C. burnetii</em> and <em>Brucella</em> spp. from domestic animals to wildlife and vice versa, associated with anthropogenic activities like farming, as those pathogens have a high prevalence in cattle and dogs in Ecuador. In conclusion, wildlife illegal traffic represents a threat to conservation, animal welfare, and public health issues that need to be managed with One Health-inspired policies, like educational programs warning about the risk of wildlife possession for humans and domestic animals.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101045"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pets in the household increase ocular surface microbiome exchanges between dog and owner","authors":"Suzanne Bianca Clougher ,&nbsp;Camilla Miorelli ,&nbsp;Annalisa Astolfi ,&nbsp;Adriano Zaghi ,&nbsp;Alessandra Scagliarini ,&nbsp;Piera Versura","doi":"10.1016/j.onehlt.2025.101044","DOIUrl":"10.1016/j.onehlt.2025.101044","url":null,"abstract":"<div><div>The evidence of antibiotic-resistant bacteria-sharing between pets and owners and the increasing number of households with pets call attention to microbial exchanges between animals and humans at home. Sharing of allergic traits and of skin, oral, and gut microbiomes between dogs and owners has been demonstrated in multiple studies, highlighting the existence and importance of non-pathogenic microbial exchanges, and calling for a One Health approach to study the microbiomes. This study investigates sharing of ocular surface microbiome between dogs and owners by characterizing dog and owner ocular microbiomes, and evaluating the impact of several lifestyle factors on microbiome similarities between them.</div><div>To this aim, conjunctival swabs were collected from 15 dogs and their owners for subsequent DNA extraction and 16S rRNA V3-V4 regions sequencing. Microbiome composition and alpha diversity were determined for dogs and owners. Beta diversity was estimated with weighted UniFrac distance, unweighted UniFrac distance, and Bray-Curtis dissimilarity. Dog-owner distances, i.e. beta diversity in each dog-owner pair, were calculated to estimate the level of similarity between dog and owner microbiomes. The impact of several lifestyle factors on microbiome similarities between dog and owner was investigated.</div><div>Dog and owner microbiomes were found to be similar in overall composition, harboring the same main phyla and families, albeit forming two distinct clusters and dogs having a significantly more diverse microbiome. Small dogs tended to share more microbiome with their owner than large dogs. Pairs cohabiting with other pets had a microbiome composition significantly more similar than the ones who did not.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101044"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ecological threat posed by invasive species as silent carriers of global priority bacteria to wildlife","authors":"Gabriel Siqueira dos Santos ,&nbsp;Fábio Parra Sellera ,&nbsp;João Pedro Rueda Furlan ,&nbsp;José Soares Ferreira Neto ,&nbsp;Marcos Bryan Heinemann","doi":"10.1016/j.onehlt.2025.101043","DOIUrl":"10.1016/j.onehlt.2025.101043","url":null,"abstract":"","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101043"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of influential environmental and climatic determinants on COVID-19 spread in India to formulate a sustainable pandemic response","authors":"Jaraline Kirubavathy K. ,&nbsp;Thulasi Bai V.","doi":"10.1016/j.onehlt.2025.101042","DOIUrl":"10.1016/j.onehlt.2025.101042","url":null,"abstract":"<div><div>The COVID-19 pandemic has highlighted the need for a Sustainable Pandemic Response Strategy (SPRS), driven by scientific research and engineering principles. This study focuses on Environmental and Climatic Determinants (ECDs) that may influence the occurrence pattern of infectious diseases. The objective of SPRS is to develop a climate-resilient framework for infectious diseases using Earth Observation (EO) data. ECDs were derived from EO data during the COVID-19 study period in India, spanning 1094 days (January 3, 2020, to December 31, 2022).</div><div>A Convergent Search – Add or Eliminate (CS-AE) algorithm was developed for the investigation of complex association between ECDs and disease occurrence patterns. This algorithm identifies the most influential ECDs in the spread of COVID-19 in India, categorizing them as Determinants of Concern (DOC) or Determinants of Interest (DOI). Shortwave Downward Radiation (SDR) was identified as a DOC, showing a strong correlation (<em>r</em> = 0.9525) with COVID-19 spread.</div><div>Granger causality analysis was conducted to support the classification of SDR as a Determinant of Concern (DOC). The results confirmed a temporal causal relationship between SDR and disease spread. During the first pandemic wave, significant causality was observed at lags of 2 to 7 days, with the strongest effect at lag 6 (<em>p</em> = 0.001), while in subsequent waves, significance was found across lags of 1 to 6 days. The seasonal effect of SDR and the three pandemic waves in India were observed through a radar chart, illustrating the temporal causal relationship between SDR and COVID-19 spread.</div><div>The algorithm shows the note of a significant role by SDR in surface and air temperature (<em>r</em> = 0.9525; <em>r</em> = 0.9942) and influences other ECDs which are categorized as DOI. Hence, the proposed CS-AE algorithm provides a robust tool for identifying the most influential ECDs in the spread of infectious diseases, provided the datasets are time-series based.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101042"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of West Nile virus vector co-occurrence and spatial overlap with human cases across Europe","authors":"Shirin Taheri ,&nbsp;Mikel Alexander González ,&nbsp;María José Ruiz-López ,&nbsp;Ramón Soriguer ,&nbsp;Jordi Figuerola","doi":"10.1016/j.onehlt.2025.101041","DOIUrl":"10.1016/j.onehlt.2025.101041","url":null,"abstract":"<div><div>Its geographic range expansion and rising incidence make West Nile Virus (WNV) a major public health challenge in Europe. Although numerous studies have investigated geographic variation in WNV incidence in humans or equines, most have focused on climate and land-use factors; however, the implications of vector co-occurrence and niche overlap remain largely unexplored. Identifying areas where highly competent vectors overlap with favourable environmental conditions is crucial for determining areas at risk for future WNV outbreaks.</div><div>We analysed the distribution and habitat suitability of four <em>Culex</em> mosquito vectors across Europe using an ensemble of six modelling techniques and relevant environmental variables. We generated probability maps, converted them into binary distribution maps through threshold-based methods, and weighted them by WNV vector competence to identify hotspots of vector co-occurrence and human cases.</div><div>Our findings indicate that WNV vectors are unevenly distributed across Europe, with southern regions emerging as hotspots, particularly due to the presence of highly competent vectors such as <em>Culex univittatus</em> s.l<em>., Culex modestus</em>, and <em>Culex pipiens</em>. The overlap of <em>Cx. modestus</em>, <em>Cx. torrentium</em>, and <em>Cx. pipiens</em> in central, western, and eastern Europe indicates that competent WNV vectors are present in nearly all European regions. Among the environmental factors analysed, mean winter temperatures were the most influential, suggesting that mild winters could increase the distribution of WNV competent vectors. Our results also revealed a strong spatial overlap between hotspots of human WNV cases and vector co-occurrence, highlighting regions of elevated transmission risk.</div><div>The high-risk hotspots identified in this large-scale study can guide local surveillance efforts and optimize resource allocation, ultimately enhancing the effectiveness of WNV surveillance.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101041"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design framework to develop sustainable innovations for addressing One Health challenges","authors":"Avis Anya Nowbuth ,&nbsp;Vikram Singh Parmar","doi":"10.1016/j.onehlt.2025.101031","DOIUrl":"10.1016/j.onehlt.2025.101031","url":null,"abstract":"<div><div>The complexity of global health challenges requires integrated approaches that crosses traditional boundaries. One Health (OH) offers a holistic approach to address health issues at the crossroads of human, animal, and environmental domains. Antimicrobial Resistance (AMR), a prime example of a cross-sectoral issue and OH challenge, highlights the need for coordinated interventions that consider multiple stakeholders. Current approaches to improve OH challenges and AMR have limited success, often due to a lack of a structured theoretical approach that informs the design and development of solutions for long-term sustainability. Existing frameworks focus primarily on human or veterinary sectors in isolation, leaving a gap in comprehensive, integrated approaches that align with OH principles. The proposed framework addresses this gap by offering a structured approach to both implementing and evaluating interventions that consider all three sectors.</div><div>This paper proposes the HEARTf of OHC (<em>Holistic Engagement and Adaptive Responses Theoretical framework of One Health challenges</em>), a user-centered design approach aimed at developing sustainable and innovative OHC interventions. The HEARTf of OHC integrates knowledge from social sciences, computer science, industrial design, pedagogy, and health sciences to create context specific solutions that address the specific needs of end-users in the human, animal, and environmental sectors. Additionally, this paper reviews existing frameworks addressing AMR, identifies limitations and outlines the need for a transdisciplinary approach when tackling OHC. By emphasizing the importance of the user-centered design, transdisciplinarity, and continuous evaluation, the HEARTf of OHC aims to bridge the gap between current strategies and improve the development and evaluation of innovative solutions or services. The HEARTf of OHC is a generalizable framework for the design, implementation, and evaluation of OH interventions, where we use AMR as a case study to demonstrate its application.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 101031"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}