Xiao Tang , Qianqian Tao , Liangliang Song , Erik V. Van der Eycken
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引用次数: 0
Abstract
The Ugi reaction has obtained broad interest due to mild reaction conditions and high variability. The Ugi adducts provide myriad opportunities for post-transformations, leading to heterocycles, bioactive molecules, macrocycles, polymers, natural products and drugs. Recently, dearomatization strategies have been employed in post-Ugi transformations. Through transition metal catalysis and metal-free methods, different kinds of three dimensional complex molecules are formed in an atom- and step-economic manner. This review summarizes recent advances in the combination of the Ugi-4CR and dearomatization strategies for the synthesis of spirocycles.
Ugi 反应因其反应条件温和、可变性强而受到广泛关注。多用途的乌基加合物为后转化提供了无数机会，可产生无数杂环、生物活性分子、大环、聚合物、天然产物和药物。最近，脱芳烃策略被用于乌基后转化。通过过渡金属催化和无金属方法，以原子和步骤经济的方式形成了不同种类的三维复合分子。本综述总结了结合乌基-4CR 和脱芳烃策略合成螺环的最新进展。
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