Xiao Tang, Qianqian Tao, Liangliang Song and Erik V. Van der Eycken
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引用次数: 0
Abstract
The Ugi reaction has obtained broad interest due to mild reaction conditions and high variability. The Ugi adducts provide myriad opportunities for post-transformations, leading to heterocycles, bioactive molecules, macrocycles, polymers, natural products and drugs. Recently, dearomatization strategies have been employed in post-Ugi transformations. Through transition metal catalysis and metal-free methods, different kinds of three dimensional complex molecules are formed in an atom- and step-economic manner. This review summarizes recent advances in the combination of the Ugi-4CR and dearomatization strategies for the synthesis of spirocycles.
Ugi 反应因其反应条件温和、可变性强而受到广泛关注。多用途的乌基加合物为后转化提供了无数机会，可产生无数杂环、生物活性分子、大环、聚合物、天然产物和药物。最近，脱芳烃策略被用于乌基后转化。通过过渡金属催化和无金属方法，以原子和步骤经济的方式形成了不同种类的三维复合分子。本综述总结了结合乌基-4CR 和脱芳烃策略合成螺环的最新进展。
期刊介绍：
Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.
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