Physiological and cellular mechanisms of ischemic preconditioning microRNAs-mediated in underlying of ischemia/reperfusion injury in different organs.

IF 3.5 2区生物学 Q3 CELL BIOLOGY Molecular and Cellular Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-07-13 DOI:10.1007/s11010-024-05052-7

Izadpanah Gheitasi, Ghaidafeh Akbari, Feryal Savari

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Abstract

Ischemia-reperfusion (I/R) injury, as a pathological phenomenon, takes place when blood supply to an organ is disrupted and then aggravated during restoration of blood flow. Ischemic preconditioning (IPC) is a potent method for attenuating subsequent events of IR damage in numerous organs. IPC protocol is determined by a brief and sequential time periods of I/R before the main ischemia. MicroRNAs are endogenous non-coding RNAs that regulate post-transcriptionally target mRNA translation via degrading it and/or suppressing protein synthesis. This review introduces the physiological and cellular mechanisms of ischemic preconditioning microRNAs-mediated after I/R insult in different organs such as the liver, kidney, heart, brain, and intestine. Data of this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2023. Based on these literature studies, IPC/IR intervention can affect cellular mechanisms including oxidative stress, apoptosis, angiogenesis, and inflammation through up-regulation or down-regulation of multiple microRNAs and their target genes.

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在不同器官缺血/再灌注损伤的基础上，缺血预处理微RNA介导的生理和细胞机制。

缺血再灌注（I/R）损伤作为一种病理现象，发生于器官供血中断，然后在血流恢复时加重。缺血预处理（IPC）是一种有效的方法，可减轻许多器官随后发生的红外损伤。缺血预处理方案由主缺血前短暂而有序的I/R时间段决定。微RNA是一种内源性非编码RNA，可通过降解和/或抑制蛋白质合成来调节转录后目标mRNA的翻译。本综述介绍了肝脏、肾脏、心脏、大脑和肠道等不同器官在I/R损伤后缺血预处理微RNA介导的生理和细胞机制。本综述的数据来自 2000 年至 2023 年期间在 Science Direct、Scopus、PubMed、Web of Science 和科学信息数据库等数据库中发表的科学文章。根据这些文献研究，IPC/IR干预可通过上调或下调多种microRNA及其靶基因来影响细胞机制，包括氧化应激、细胞凋亡、血管生成和炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.