Healthcare costs and medical utilization patterns associated with painful and severe painful diabetic peripheral neuropathy.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-12-01 Epub Date: 2024-07-13 DOI:10.1007/s12020-024-03954-6
Todd Bromberg, Nicolas C Gasquet, Christine N Ricker, Charlotte Wu
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Abstract

Purpose: Painful diabetic peripheral neuropathy (DPN) is a common complication in patients with diabetes. It is associated with a poor quality of life and high costs of care. This study investigated the impact of painful DPN on healthcare costs and resource utilization.

Methods: This was a retrospective analysis of administrative claims of adult patients with diabetes (type 1 or 2) from Optum's de-identified Clinformatics® Data Mart Database. Patients were assigned to four cohorts by presence of DPN and pain severity, based on diagnoses and prescription patterns in a one-year baseline. All-cause and diabetes-associated costs were calculated for the year following the index DPN diagnosis. Risk factors associated with presence of severely painful DPN were evaluated.

Results: Relative to those without DPN, patients who had DPN without pain, painful DPN (PDPN), or severe PDPN incurred respective increases of $3,093, $9,349, and $20,887 in average annual all-cause costs. More than half of costs from painful/severe DPN were for prescriptions and inpatient hospitalization. Severe PDPN was associated with elevated odds of diabetic amyotrophy (OR: 8.09; 95% CI: 6.84-9.56), diabetic foot ulcers (OR: 6.54, 95% CI: 6.32-6.76), and loss of mobility (OR: 2.54, 95% CI: 2.48-2.60), among other complications.

Conclusions: Painful DPN is associated with higher healthcare costs and resource utilization, and a greater risk of debilitating conditions that limit quality of life. Future research should focus on better treatment options and more aggressive pain management strategies to reduce the negative impacts of DPN.

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与疼痛性和重度疼痛性糖尿病周围神经病变相关的医疗成本和医疗利用模式。
目的:疼痛性糖尿病周围神经病变(DPN)是糖尿病患者常见的并发症。它与生活质量低下和高昂的医疗费用有关。本研究调查了疼痛性 DPN 对医疗成本和资源利用的影响:这是一项回顾性分析,研究对象是 Optum 的去标识 Clinformatics® Data Mart 数据库中的成年糖尿病患者(1 型或 2 型)的行政索赔。根据一年基线的诊断和处方模式,按照是否存在 DPN 和疼痛严重程度将患者划分为四个组群。在指数 DPN 诊断后的一年中,计算了全因成本和糖尿病相关成本。评估了与出现严重疼痛的 DPN 相关的风险因素:与没有 DPN 的患者相比,无痛性 DPN、疼痛性 DPN(PDPN)或严重疼痛性 DPN 患者的年均全因费用分别增加了 3093 美元、9349 美元和 20887 美元。疼痛型/重度 DPN 的一半以上费用用于处方和住院治疗。严重 DPN 与糖尿病肌萎缩症(OR:8.09;95% CI:6.84-9.56)、糖尿病足溃疡(OR:6.54;95% CI:6.32-6.76)和丧失活动能力(OR:2.54;95% CI:2.48-2.60)等并发症的发生几率升高有关:结论:疼痛型 DPN 与较高的医疗成本和资源利用率相关,而且更有可能出现限制生活质量的衰弱状况。未来的研究应侧重于更好的治疗方案和更积极的疼痛管理策略,以减少 DPN 的负面影响。
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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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