Stereoselective Synthesis of α‐Azido Esters and α‐Amino Acid Derivatives via Matteson Homologation of Boronic Esters

Uli Kazmaier, Alexander Horn, Emanuel Papadopoulos, Thorsten Kinsinger, Jennifer Greve, Etienne Bickel, Stavroula Pachoula
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Abstract

Matteson homologation with sodium azide in DMF proved to be an excellent highly stereoselective tool for the synthesis of complex α‐azido and α‐amino acids. Both enantiomers are easily accessible via the choice of the chiral boronic ester auxiliary.
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通过硼酸酯的马特松同系物立体选择性合成 α-叠氮酯和α-氨基酸衍生物
事实证明,在 DMF 中用叠氮化钠进行马特松同源反应是合成复杂的 α-叠氮和 α-氨基酸的一种极好的高立体选择性工具。通过选择手性硼酸酯助剂,两种对映体都很容易获得。
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