Recent Advances on Synthesis of 2H‐Chromenes, and Chromenes Fused Hetrocyclic Compounds

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-10-01 DOI:10.1002/ajoc.202400259
Rohit Kumar Maurya , Ashutosh Dey , Vikash Kumara , Mahender Khatravath
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Abstract

Chromenes and 2H‐Chromenes are vital components of natural products, pharmaceuticals, and agrochemicals that have captured the attention of researchers worldwide. These heterocyclic compounds represent an essential class of structural scaffolds, and the quest for their synthesis in a mild and straightforward way has gained significant momentum. Chromenes are oxygen‐containing heterocycles that have been widely studied due to their potential medicinal properties. In the last two decades, researchers have made remarkable progress towards the synthesis of chromene based heterocyclic compounds using O‐propargylated benzaldehydes as a substrate. These substrates are highly versatile and contain functional groups that make them ideal for a wide range of reactions. This review article provides an in‐depth analysis of the latest advances in alkynes’ functionalization, emphasizing the substrate scope, limitations, regioselectivity control, and applications of these reactions. The review also covers a range of critical methods and strategies, including multicomponent reactions, used for the general synthesis of numerous types of chromene derivatives.

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2H-Chromenes 和 Chromenes Fused Hetrocyclic 化合物合成的最新进展
苯并吡喃和 2H 苯并吡喃是天然产品、药物和农用化学品的重要组成部分,吸引着全球研究人员的目光。这些杂环化合物是一类重要的结构支架,以温和、直接的方式合成它们的研究已取得了显著的进展。色烯是一种含氧杂环化合物,因其潜在的药用特性而被广泛研究。在过去二十年中,研究人员以 O-丙炔基苯甲醛为底物合成色烯类杂环化合物的研究取得了显著进展。这些底物用途广泛,所含的官能团使其成为各种反应的理想选择。这篇综述文章深入分析了炔烃官能化的最新进展,强调了这些反应的底物范围、局限性、区域选择性控制和应用。综述还涵盖了一系列关键的方法和策略,包括多组分反应,这些方法和策略用于多种类型色烯衍生物的一般合成。
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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