{"title":"Huntingtin, the Major Factor in Huntington’s Disease Development. Main Functions and Intracellular Proteolysis","authors":"N. N. Gotmanova, A. V. Bacheva","doi":"10.3103/s0027131424700160","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s disease and the central role of huntingtin protein in these processes. The features of mutant huntingtin aggregates utilization by the ubiquitin–proteasome system and autophagy, as well as the possibilities of polyglutamine-containing substrates hydrolysis by proteasome are discussed.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3103/s0027131424700160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
This review is devoted to the consideration of pathological intracellular mechanisms characteristic of Huntington’s disease and the central role of huntingtin protein in these processes. The features of mutant huntingtin aggregates utilization by the ubiquitin–proteasome system and autophagy, as well as the possibilities of polyglutamine-containing substrates hydrolysis by proteasome are discussed.
期刊介绍：
Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.
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