Pub Date : 2024-06-04DOI: 10.3103/s0027131424700019
O. V. Maslova, O. V. Senko, N. A. Stepanov, I. V. Lyagin, E. N. Efremenko
Abstract
Waste from the production and use of synthetic polymers is a serious problem. The development of enzymatic and microbial biocatalysts capable of degrading hard-to-decompose polymers seems to be one of the promising and environmentally oriented solutions to this problem. A possibility of combining biocatalysts (BCs)—enzymes and microbial cells—with metal catalysts is considered as a promising basis for the development of new hybrid chemobiocatalytic processes intended for the effective degradation of synthetic polymers (SPs).
{"title":"Biocatalysis in the Degradation of Synthetic Polymers","authors":"O. V. Maslova, O. V. Senko, N. A. Stepanov, I. V. Lyagin, E. N. Efremenko","doi":"10.3103/s0027131424700019","DOIUrl":"https://doi.org/10.3103/s0027131424700019","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Waste from the production and use of synthetic polymers is a serious problem. The development of enzymatic and microbial biocatalysts capable of degrading hard-to-decompose polymers seems to be one of the promising and environmentally oriented solutions to this problem. A possibility of combining biocatalysts (BCs)—enzymes and microbial cells—with metal catalysts is considered as a promising basis for the development of new hybrid chemobiocatalytic processes intended for the effective degradation of synthetic polymers (SPs).</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-04DOI: 10.3103/s0027131424700020
A. M. Rozhkova, Yu. A. Denisenko, I. G. Sinelnikov, I. N. Zorov, D. V. Erokhin, V. G. Dzhavakhia
Abstract
Expression of recombinant proteins is important for studying their biological functions. For the primary description of protein properties, the E. coli expression system is most often used. However, in overexpression conditions, the rate of aggregation of target proteins often exceeds the rate of proper folding, resulting in the formation of insoluble inclusion bodies. Inclusion bodies are a clear disadvantage of the E. coli expression system since they prevent the extraction of target recombinant proteins. The use of chaperone-like proteins in vitro while refolding a target protein is one of the solutions to the existing problem. In this study, the MF3 recombinant protein is an example of a chaperone-like protein, which increases the yield of soluble plant chitinase by 92% compared to the yield of this protein using the standard refolding procedure.
{"title":"Application of MF3 Microbial Recombinant Protein in Refolding of Plant Chitinase","authors":"A. M. Rozhkova, Yu. A. Denisenko, I. G. Sinelnikov, I. N. Zorov, D. V. Erokhin, V. G. Dzhavakhia","doi":"10.3103/s0027131424700020","DOIUrl":"https://doi.org/10.3103/s0027131424700020","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Expression of recombinant proteins is important for studying their biological functions. For the primary description of protein properties, the <i>E. coli</i> expression system is most often used. However, in overexpression conditions, the rate of aggregation of target proteins often exceeds the rate of proper folding, resulting in the formation of insoluble inclusion bodies. Inclusion bodies are a clear disadvantage of the <i>E. coli</i> expression system since they prevent the extraction of target recombinant proteins. The use of chaperone-like proteins in vitro while refolding a target protein is one of the solutions to the existing problem. In this study, the MF3 recombinant protein is an example of a chaperone-like protein, which increases the yield of soluble plant chitinase by 92% compared to the yield of this protein using the standard refolding procedure.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.
{"title":"Solubility Study of Amlodipine Besylate in Ethylene Glycol + 2-Propanol Mixtures at Different Temperatures","authors":"Homa Rezaei, Kader Poturcu, Abolghasem Jouyban, Hongkun Zhao, Elaheh Rahimpour","doi":"10.3103/s0027131424010048","DOIUrl":"https://doi.org/10.3103/s0027131424010048","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Solubility behavior of amlodipine besylate (ADB) was investigated in the binary mixtures of ethylene glycol + 2-propanol at five different temperatures (293.2–313.2 K). The solubility results obtained from the shake-flask method are correlated with some reported cosolvency models (i.e. the van’t Hoff, combined nearly ideal binary solvent/Redlich–Kister, the Jouyban–Acree, the Jouyban–Acree–van’t Hoff, the mixture response surface, the modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models is investigated with the mean relative deviations of the back-calculated solubility data.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010073
A. V. Pirogov, S. M. Staroverov
Abstract
This article studies the development of a simple chromatographic method for the simultaneous determination of well-known antiseptics—chlorhexidine and triclosan—in new-generation antiseptic liquids. The dependencies of the retention times of chlorhexidine and triclosan on the concentration of acetonitrile in the mobile phase (30 to 60%) and pH (in a range of 3–8 units) for Luna C18, Nucleosil CN, and Diasfer C4 sorbents are studied. Ideal separation of chlorhexidine, p-chloroaniline (the most toxic decomposition product of chlorhexidine), dibutyl phthalate (as a component of cosmetic alcohol), triclosan, and ionol (butylhydroxytoluene (BHT) and E321—an antioxidant agent) during 20 min in the gradient elution mode on a column with a domestic Diasfer C4 sorbent is demonstrated.
{"title":"Simultaneous Determination of Chlorhexidine, p-Chloroaniline, Triclosan, Dibutyl Phthalate, and Ionol in an Antibacterial Liquid by HPLC with Spectrophotometric Detection","authors":"A. V. Pirogov, S. M. Staroverov","doi":"10.3103/s0027131424010073","DOIUrl":"https://doi.org/10.3103/s0027131424010073","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>This article studies the development of a simple chromatographic method for the simultaneous determination of well-known antiseptics—chlorhexidine and triclosan—in new-generation antiseptic liquids. The dependencies of the retention times of chlorhexidine and triclosan on the concentration of acetonitrile in the mobile phase (30 to 60%) and pH (in a range of 3–8 units) for Luna C18, Nucleosil CN, and Diasfer C4 sorbents are studied. Ideal separation of chlorhexidine, <i>p</i>-chloroaniline (the most toxic decomposition product of chlorhexidine), dibutyl phthalate (as a component of cosmetic alcohol), triclosan, and ionol (butylhydroxytoluene (BHT) and E321—an antioxidant agent) during 20 min in the gradient elution mode on a column with a domestic Diasfer C4 sorbent is demonstrated.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010085
S. E. Pratskova, D. R. Khudaiberdina
Abstract
A spectrophotometric procedure for the quantitative determination of copper(II) by a reaction of complex formation with pyrogallol red in the presence of cationic and nonionic surfactants is proposed. The optimum conditions for the analysis are determined. The procedure is tested for the determination of copper(II) in a sample of a soil extract. The following metrological characteristics of the proposed procedure are assessed: the limit of detection is 0.12 mg/kg of soil and the relative standard deviation is <0.05.
{"title":"Spectrophotometric Determination of Copper(II) in Soil in the Form of a Pyrogallol Red Complex in the Presence of Surfactants","authors":"S. E. Pratskova, D. R. Khudaiberdina","doi":"10.3103/s0027131424010085","DOIUrl":"https://doi.org/10.3103/s0027131424010085","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A spectrophotometric procedure for the quantitative determination of copper(II) by a reaction of complex formation with pyrogallol red in the presence of cationic and nonionic surfactants is proposed. The optimum conditions for the analysis are determined. The procedure is tested for the determination of copper(II) in a sample of a soil extract. The following metrological characteristics of the proposed procedure are assessed: the limit of detection is 0.12 mg/kg of soil and the relative standard deviation is <0.05.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010103
O. A. Soboleva
Abstract
The stability of aqueous dispersions of detonation nanodiamonds (NDs) in the presence of polyvinyl alcohol (PVA) is studied. It is found that PVA additives with a concentration above 0.1 wt % cause the formation of aggregates. To increase the stability of dispersions of NDs, it is proposed to add a stabilizer—an anionic surfactant sodium dodecyl sulfate (SDS)—into the system. As a result of the simultaneous stabilizing action of an SDS–PVA mixture, the aggregation stability of aqueous dispersions of NDs noticeably increases, while the particle size in the dispersions remains unchanged for several days.
{"title":"The Influence of Polyvinyl Alcohol on the Stability of Aqueous Dispersions of Nanodiamonds","authors":"O. A. Soboleva","doi":"10.3103/s0027131424010103","DOIUrl":"https://doi.org/10.3103/s0027131424010103","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The stability of aqueous dispersions of detonation nanodiamonds (NDs) in the presence of polyvinyl alcohol (PVA) is studied. It is found that PVA additives with a concentration above 0.1 wt % cause the formation of aggregates. To increase the stability of dispersions of NDs, it is proposed to add a stabilizer—an anionic surfactant sodium dodecyl sulfate (SDS)—into the system. As a result of the simultaneous stabilizing action of an SDS–PVA mixture, the aggregation stability of aqueous dispersions of NDs noticeably increases, while the particle size in the dispersions remains unchanged for several days.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010097
K. G. Seravkin, K. A. Potekhin, A. M. Banaru
Abstract
Lattice tilings of a plane into polyominoes are constructed for N from 3 to 12, where N is the order of the packing space. A total of 5191 symmetrically independent lattice tilings of the plane with one polyomino in a reduced (primitive) cell are obtained, among which 122 variants belong to the structural class (SC) cm, Z = 2(m), with a rectangular conventional (centered) unit cell. Chain tilings of the plane are derived, for which both the SC and structural subclass (SSC) are identified. The results of the analysis of the lattice tilings of a plane into polyominoes are illustrated with examples of real molecular layers in crystal structures.
摘要 构建了从 3 到 12 个 N 的平面多角形网格倾斜图，其中 N 是堆积空间的阶数。总共得到了 5191 个对称独立的、在缩小（原始）单元中有一个多面体的平面点阵，其中 122 个变体属于结构类（SC）cm，Z = 2(m)，具有矩形常规（居中）单元格。推导出了平面的链状倾斜，并确定了 SC 和结构亚类（SSC）。以晶体结构中的实际分子层为例，说明了将平面的晶格倾斜分析为多面体的结果。
{"title":"Lattice Tilings of a Plane into Polyominoes and Molecular Layers in Crystal Structures: Structural Class cm, Z = 2(m)","authors":"K. G. Seravkin, K. A. Potekhin, A. M. Banaru","doi":"10.3103/s0027131424010097","DOIUrl":"https://doi.org/10.3103/s0027131424010097","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Lattice tilings of a plane into polyominoes are constructed for <i>N</i> from 3 to 12, where <i>N</i> is the order of the packing space. A total of 5191 symmetrically independent lattice tilings of the plane with one polyomino in a reduced (primitive) cell are obtained, among which 122 variants belong to the structural class (SC) <i>cm</i>, <i>Z</i> = 2(<i>m</i>), with a rectangular conventional (centered) unit cell. Chain tilings of the plane are derived, for which both the SC and structural subclass (SSC) are identified. The results of the analysis of the lattice tilings of a plane into polyominoes are illustrated with examples of real molecular layers in crystal structures.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140576177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010024
Ahmad Gholizadeh, Seyed Esmaeil Yazdanpanah
Abstract
As insecticides, fungicides, heavy metals, and aflatoxins enter the food chain, they cause adverse effects on living organisms and humans. Given that rice is a widely-consumed food in Iran, the present study aimed to investigate the probability of the existence of insecticides, fungicides, heavy metals, and aflatoxins, as well as the nutritional value of rice in Mazandaran province. To this end, four cultivars of rice, namely Tarom, Fajr, Neda, and Shiroodi rice were collected from farms in the region, and after preparation, the concentration of pollutants in rice was measured in different ways in the laboratory. SPSS 25 software was used to analyze data. Based on the findings, the average nutritional value of four cultivars of rice was high in terms of protein (8.575 ± 0.298 g), fiber (less than 1), fat (1.2 g), carbohydrates (81.725 ± 0.512 g), calcium (405.64 ± 0.81 ppm), and B vitamins, where the average of vitamin B1 was 2.775 ± 1.305 g, vitamin B2 was 3.5 ± 1.62 g, vitamin B3 and B6 were less than 0.2, and vitamin B12 was less than 5. Heavy metals (less than 0.1 ppm), arsenic (0.095 ± 0.338 ppm), and cadmium (less than 0.025 ppm) were lower than the standard level. Due to the proximity of heavy metals to the standard, its status was considered critical. The average concentrations of aflatoxins, insecticides, fungicides, and herbicides were standard in different cultivars of rice. Given the nutritional value, the standard level of pollutants, and the health of Iranian rice species, rice consumption is recommended in diets and exports.
{"title":"Evaluation of the Nutritional Value, Toxins and Pollutants in Mazandaran Rice and Detection of the Rice Health Level","authors":"Ahmad Gholizadeh, Seyed Esmaeil Yazdanpanah","doi":"10.3103/s0027131424010024","DOIUrl":"https://doi.org/10.3103/s0027131424010024","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>As insecticides, fungicides, heavy metals, and aflatoxins enter the food chain, they cause adverse effects on living organisms and humans. Given that rice is a widely-consumed food in Iran, the present study aimed to investigate the probability of the existence of insecticides, fungicides, heavy metals, and aflatoxins, as well as the nutritional value of rice in Mazandaran province. To this end, four cultivars of rice, namely Tarom, Fajr, Neda, and Shiroodi rice were collected from farms in the region, and after preparation, the concentration of pollutants in rice was measured in different ways in the laboratory. SPSS 25 software was used to analyze data. Based on the findings, the average nutritional value of four cultivars of rice was high in terms of protein (8.575 ± 0.298 g), fiber (less than 1), fat (1.2 g), carbohydrates (81.725 ± 0.512 g), calcium (405.64 ± 0.81 ppm), and B vitamins, where the average of vitamin B1 was 2.775 ± 1.305 g, vitamin B2 was 3.5 ± 1.62 g, vitamin B3 and B6 were less than 0.2, and vitamin B12 was less than 5. Heavy metals (less than 0.1 ppm), arsenic (0.095 ± 0.338 ppm), and cadmium (less than 0.025 ppm) were lower than the standard level. Due to the proximity of heavy metals to the standard, its status was considered critical. The average concentrations of aflatoxins, insecticides, fungicides, and herbicides were standard in different cultivars of rice. Given the nutritional value, the standard level of pollutants, and the health of Iranian rice species, rice consumption is recommended in diets and exports.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010061
V. N. Matveenko, E. A. Kirsanov
Abstract
A new interpretation is proposed for the dependence of dynamic moduli on the strain amplitude in the course of shear vibrations at a fixed vibration frequency. The interpretation is based on a structural rheological model that includes kinetic equations for the formation and destruction of particles’ aggregates under the action of an oscillating shear flow. The rheological equations, which can be used for the approximation of rheological curves G'(γ0) and G''(γ0) in separate sections with different amplitudes of the shear strain, are obtained. The possibilities of the new rheological model are demonstrated through the example of two polymer systems with solid particle-based fillers.
{"title":"Rheology of Structured Liquids: Dependence of Dynamic Moduli on Strain Amplitude","authors":"V. N. Matveenko, E. A. Kirsanov","doi":"10.3103/s0027131424010061","DOIUrl":"https://doi.org/10.3103/s0027131424010061","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A new interpretation is proposed for the dependence of dynamic moduli on the strain amplitude in the course of shear vibrations at a fixed vibration frequency. The interpretation is based on a structural rheological model that includes kinetic equations for the formation and destruction of particles’ aggregates under the action of an oscillating shear flow. The rheological equations, which can be used for the approximation of rheological curves <i>G</i>'(γ<sub>0</sub>) and <i>G</i>''(γ<sub>0</sub>) in separate sections with different amplitudes of the shear strain, are obtained. The possibilities of the new rheological model are demonstrated through the example of two polymer systems with solid particle-based fillers.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-02DOI: 10.3103/s0027131424010036
Dinesh. R. Godhani, Anwar. H. Saiyad, Jignasu. P. Mehta, Umang. P. Mehta
Abstract
We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, 1H NMR, 13C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative E. coli and compound 9m (MIC = 50 μg/mL) showed potent activity against P. aeruginosa. While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against C. albicans.
{"title":"Synthesis and Biological Evaluation Studies of Novel 1,3,4-Oxadiazole and Benzo[d]imidazole Scaffolds as Promising Antimicrobial Agents","authors":"Dinesh. R. Godhani, Anwar. H. Saiyad, Jignasu. P. Mehta, Umang. P. Mehta","doi":"10.3103/s0027131424010036","DOIUrl":"https://doi.org/10.3103/s0027131424010036","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>We prepared a novel series of 1,3,4-oxadiazole and benzo[d]imidazolecontaining fi fteen new connections to develop potential antimicrobial agents (9a–9o). The structures of this new series were characterized by various spectral techniques like IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, LC–MS, and elemental analysis. Using the Broth Dilution method, the hybrids were examined for antimicrobial activity against a variety of bacterial and fungal strains. Compound 9n (MIC = 50 μg/mL) exhibited good activity against gramnegative <i>E. coli</i> and compound 9m (MIC = 50 μg/mL) showed potent activity against <i>P. aeruginosa.</i> While compounds 9c, 9f, 9g and 9m indicated MIC = 250 μg/mL against <i>C. albicans</i>.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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