Biopolymer Controlled Release Systems Based on Hydrolyzed Collagen: Cryoforming, Structure, and Properties

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Moscow University Chemistry Bulletin Pub Date : 2024-07-11 DOI:10.3103/s0027131424700147

A. A. Makeeva, A. S. Shumilkin, A. S. Ryzhkova, O. I. Vernaya, A. V. Shabatin, A. M. Semenov, T. I. Shabatina

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Abstract

Biopolymer materials based on natural collagen (gelatin, hydrolyzed collagen) are widely used in the food, pharmaceutical, and cosmetic industries due to their low toxicity, high biocompatibility, low antigenicity, and unique mechanical and technological properties. Hydrolyzed collagen, unlike gelatin, is formed by peptides with a lower molecular weight. Its advantages are higher bioavailability and biodegradability in comparison with gelatin. In this study, biopolymer matrices containing a dioxidine antibacterial drug are obtained based on hydrolyzed collagen using low-temperature technologies. It is shown that, varying synthesis parameters such as the concentration of hydrolyzed collagen in the precursor solution (from 1 to 10%), matrix crosslinking time (0.1–24 h), and cryoforming temperature (–30 and –196°C), it is possible to change the morphology and structure of the matrix, its degradation time, and drug release time. The composition and structure of dioxidine/hydrolyzed collagen systems are characterized by SEM and IR and UV spectroscopy. The antibacterial activity of the resulting dioxidine/hydrolyzed collagen systems against E. coli and S. aureus is characterized by the disk diffusion method.

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基于水解胶原蛋白的生物聚合物控释系统：冷冻成型、结构和特性

摘要基于天然胶原蛋白（明胶、水解胶原蛋白）的生物聚合物材料因其低毒性、高生物相容性、低抗原性以及独特的机械和技术特性而被广泛应用于食品、制药和化妆品行业。水解胶原蛋白与明胶不同，是由分子量较低的肽形成的。与明胶相比，水解胶原蛋白的优点是生物利用率和生物降解性更高。本研究利用低温技术，在水解胶原蛋白的基础上获得了含有二恶烷抗菌药物的生物聚合物基质。研究表明，通过改变合成参数，如前驱体溶液中水解胶原蛋白的浓度（从 1%到 10%）、基质交联时间（0.1-24 小时）和低温成型温度（-30 和 -196°C），可以改变基质的形态和结构、降解时间和药物释放时间。二恶英/水解胶原系统的组成和结构通过扫描电镜、红外和紫外光谱进行表征。采用磁盘扩散法测定了所得二恶英/水解胶原系统对大肠杆菌和金黄色葡萄球菌的抗菌活性。

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来源期刊

Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.30

自引率

14.30%

发文量

期刊介绍： Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.