Neuraminidase Inhibitory Activities of Some Alcoholic Plant Extracts and Chemical Compounds

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY Moscow University Chemistry Bulletin Pub Date : 2024-07-11 DOI:10.3103/s0027131424700214
Onur Ertik, Refiye Yanardag
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Abstract

In today’s world, disease rates are increasing day after day because of environmental factors, lifestyles and technology. Although there are many drugs for many diseases, people’s interest and demand for herbal products are increasing. So, plants that can be used in the treatment of diseases have to be researched scientifically. Neuraminidase belongs to a class of glycosyl hydrolases that release terminal sialic acid from glycoproteins, glycolipids and polysaccharides. Neuraminidases could be found in animals, microorganisms and viruses. They have an impact on pathogenicity. This enzyme which is required for viral replication is a surface glycoprotein in influenza types A and B. In this study, we examined the inhibitory effects of some plant extracts and chemical compounds on neuraminidase activity. The result of our experiments indicates that the neuraminidase inhibitory activities of plant extracts and chemical compounds increased in a dose-dependent manner. We can conclude that the plant extracts and chemicals/drugs can be used in pharmaceutical industries and drug treatment due to their neuraminidase inhibitory activities.

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一些含酒精植物提取物和化合物的神经氨酸酶抑制活性
摘要 在当今世界,由于环境因素、生活方式和技术的影响,疾病的发病率与日俱增。虽然有许多药物可以治疗许多疾病,但人们对草药产品的兴趣和需求却在不断增加。因此,必须对可用于治疗疾病的植物进行科学研究。神经氨酸酶属于糖基水解酶的一种,可从糖蛋白、糖脂和多糖中释放末端的硅酸。神经氨酸酶存在于动物、微生物和病毒中。它们对致病性有影响。本研究考察了一些植物提取物和化合物对神经氨酸酶活性的抑制作用。实验结果表明,植物提取物和化合物对神经氨酸酶的抑制活性呈剂量依赖性增加。我们可以得出结论,由于植物提取物和化学物质/药物具有抑制神经氨酸酶的活性,它们可用于制药业和药物治疗。
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来源期刊
Moscow University Chemistry Bulletin
Moscow University Chemistry Bulletin CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
1.30
自引率
14.30%
发文量
38
期刊介绍: Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.
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