Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL Bio-Design and Manufacturing Pub Date : 2024-07-11 DOI:10.1007/s42242-024-00279-1
Qingge Wang, Jia Liu, Hong Wu, Jingbo Liu, Yaojia Ren, Luxin Liang, Xinxin Yan, Ian Baker, Shifeng Liu, V. V. Uglov, Chengliang Yang, Liqiang Wang
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Abstract

理想的钛基关节植入物应避免力屏蔽, 且具有良好的生物活性和抗感染性能。为满足这些要求, 研究人员以低弹性模量合金Ti–35Nb–2Ta–3Zr为基底, 采用阳极化、沉积和旋涂等方法制备含有生物陶瓷和银离子的功能涂层, 并将其涂覆在TiO2纳米管 ((80 ± 20) nm 和(150 ± 40) nm) 表面。研究了生物陶瓷 (nano-β-TCP, micro-HA, meso-CaSiO3) 和Ag纳米颗粒 ((50 ± 20) nm) 对纳米管的抗菌活性、摩擦、腐蚀和早期体外成骨行为的影响。摩擦和腐蚀结果表明, 磨损率和腐蚀速率与纳米管表面形貌密切相关。由于粘着磨损和磨粒磨损, 生物陶瓷micro-HA 表现出优异的耐磨性, 磨损率为(1.26 ± 0.06)×10–3 mm3/(N m)。生物陶瓷meso-CaSiO3显示出良好的细胞粘附、增殖能力和碱性磷酸酶活性。含有纳米银的涂层具有良好的抗菌活性, 对大肠杆菌的抗菌率 ≥ 89.5%。研究结果表明, 该功能涂层具有加速成骨的潜力。

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利用含有纳米银的纳米管和体外生物陶瓷增强耐磨性、抗菌性能和生物相容性
理想的钛基关节植入物应避免力屏蔽, 且具有良好的生物活性和抗感染性能。为满足这些要求, 研究人员以低弹性模量合金Ti–35Nb–2Ta–3Zr为基底, 采用阳极化、沉积和旋涂等方法制备含有生物陶瓷和银离子的功能涂层, 并将其涂覆在TiO2纳米管 ((80 ± 20) nm和(150 ± 40) nm) 表面。研究了生物陶瓷 (nano-β-TCP, micro-HA, meso-CaSiO3) 和Ag纳米颗粒 ((50 ± 20) nm) 对纳米管的抗菌活性、摩擦、腐蚀和早期体外成骨行为的影响。摩擦和腐蚀结果表明, 磨损率和腐蚀速率与纳米管表面形貌密切相关。由于粘着磨损和磨粒磨损, 生物陶瓷micro-HA 表现出优异的耐磨性, 磨损率为(1.26 ± 0.06)×10–3 mm3/(N m)。生物陶瓷meso-CaSiO3显示出良好的细胞粘附、增殖能力和碱性磷酸酶活性。含有纳米银的涂层具有良好的抗菌活性, 对大肠杆菌的抗菌率 ≥ 89.5%。研究结果表明, 该功能涂层具有加速成骨的潜力。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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