Jetting-based bioprinting: process, dispense physics, and applications

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL Bio-Design and Manufacturing Pub Date : 2024-07-12 DOI:10.1007/s42242-024-00285-3
Wei Long Ng, Viktor Shkolnikov
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Abstract

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells, growth factors, drugs, and biomaterials in a highly automated layer-by-layer fabrication approach. Due to its immense versatility, jetting-based bioprinting has been used for various applications, including tissue engineering and regenerative medicine, wound healing, and drug development. A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting. This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting. We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting, laser-induced forward transfer bioprinting, electrohydrodynamic jet bioprinting, acoustic bioprinting and microvalve bioprinting. Next, we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition, print chamber design, droplet formation and droplet impact. Finally, we highlight recent accomplishments in jetting-based bioprinting. We present the advantages and challenges of each method, discuss considerations relating to cell viability and protein stability, and conclude by providing insights into future directions of jetting-based bioprinting.

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基于喷射的生物打印:工艺、点胶物理和应用
基于喷射技术的生物打印技术可按需无接触地将亚纳升液滴沉积在定义明确的位置,从而以高度自动化的逐层制造方法控制细胞、生长因子、药物和生物材料的空间排列。基于喷射技术的生物打印技术具有巨大的多功能性,已被广泛应用于各种领域,包括组织工程和再生医学、伤口愈合和药物开发。人们对基于喷射技术的生物打印过程缺乏深入了解。本综述论文将全面讨论生物墨水的物理因素和喷射式生物打印中使用的打印条件。我们首先概述了不同的喷射式生物打印技术,如喷墨生物打印、激光诱导正向转移生物打印、电流体动力喷射生物打印、声学生物打印和微阀生物打印。接下来,我们将深入探讨生物墨水配方中与细胞沉积、打印室设计、液滴形成和液滴影响有关的各种注意事项。最后,我们重点介绍了基于喷射的生物打印技术的最新成果。我们介绍了每种方法的优势和挑战,讨论了与细胞存活率和蛋白质稳定性有关的注意事项,最后对喷射式生物打印的未来发展方向提出了见解。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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