{"title":"Jetting-based bioprinting: process, dispense physics, and applications","authors":"Wei Long Ng, Viktor Shkolnikov","doi":"10.1007/s42242-024-00285-3","DOIUrl":null,"url":null,"abstract":"<p>Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells, growth factors, drugs, and biomaterials in a highly automated layer-by-layer fabrication approach. Due to its immense versatility, jetting-based bioprinting has been used for various applications, including tissue engineering and regenerative medicine, wound healing, and drug development. A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting. This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting. We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting, laser-induced forward transfer bioprinting, electrohydrodynamic jet bioprinting, acoustic bioprinting and microvalve bioprinting. Next, we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition, print chamber design, droplet formation and droplet impact. Finally, we highlight recent accomplishments in jetting-based bioprinting. We present the advantages and challenges of each method, discuss considerations relating to cell viability and protein stability, and conclude by providing insights into future directions of jetting-based bioprinting.</p><h3 data-test=\"abstract-sub-heading\">Graphic abstract</h3>\n","PeriodicalId":48627,"journal":{"name":"Bio-Design and Manufacturing","volume":null,"pages":null},"PeriodicalIF":8.1000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bio-Design and Manufacturing","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s42242-024-00285-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells, growth factors, drugs, and biomaterials in a highly automated layer-by-layer fabrication approach. Due to its immense versatility, jetting-based bioprinting has been used for various applications, including tissue engineering and regenerative medicine, wound healing, and drug development. A lack of in-depth understanding exists in the processes that occur during jetting-based bioprinting. This review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based bioprinting. We first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting, laser-induced forward transfer bioprinting, electrohydrodynamic jet bioprinting, acoustic bioprinting and microvalve bioprinting. Next, we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition, print chamber design, droplet formation and droplet impact. Finally, we highlight recent accomplishments in jetting-based bioprinting. We present the advantages and challenges of each method, discuss considerations relating to cell viability and protein stability, and conclude by providing insights into future directions of jetting-based bioprinting.
期刊介绍:
Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.