New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pure and Applied Chemistry Pub Date : 2024-07-12 DOI:10.1515/pac-2024-0224
Alfonso Canales-Martínez, Rosa M. Pérez-Pastor, Gabriel García
{"title":"New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela","authors":"Alfonso Canales-Martínez, Rosa M. Pérez-Pastor, Gabriel García","doi":"10.1515/pac-2024-0224","DOIUrl":null,"url":null,"abstract":"In this work, we describe the synthesis and characterisation of the starting materials [Cp*IrCl<jats:sub>2</jats:sub>]<jats:sub>2</jats:sub> and four new ruthenium(II) and iridium(III) complexes half sandwich, contain the fragments [(p-cymene)Ru]<jats:sup>2+</jats:sup> and [Cp*Ir]<jats:sup>2+</jats:sup>; (Cp* = Cp<jats:sup>Me4Et</jats:sup>) of stoichiometry: [Cp*IrCl<jats:sub>2</jats:sub>(2-aminopyridine)] (I), [Cp*IrCl<jats:sub>2</jats:sub>(4-aminopyridine)] (II), [Cp*IrCl<jats:sub>2</jats:sub>(adenine)] (III) and [(<jats:italic>p</jats:italic>-cymene)RuCl<jats:sub>2</jats:sub>(adenine)] (IV). The new compounds have been characterised by C, H, and N elemental analysis; infrared and <jats:sup>1</jats:sup>H NMR spectroscopy with <jats:sup>1</jats:sup>H–<jats:sup>1</jats:sup>H COSY, ESI/TOF mass spectrometry and thermogravimetry. A study of the cytotoxicity of these compounds against the Hela cell line was carried out, with results indicating a low activity.","PeriodicalId":20911,"journal":{"name":"Pure and Applied Chemistry","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pure and Applied Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1515/pac-2024-0224","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

In this work, we describe the synthesis and characterisation of the starting materials [Cp*IrCl2]2 and four new ruthenium(II) and iridium(III) complexes half sandwich, contain the fragments [(p-cymene)Ru]2+ and [Cp*Ir]2+; (Cp* = CpMe4Et) of stoichiometry: [Cp*IrCl2(2-aminopyridine)] (I), [Cp*IrCl2(4-aminopyridine)] (II), [Cp*IrCl2(adenine)] (III) and [(p-cymene)RuCl2(adenine)] (IV). The new compounds have been characterised by C, H, and N elemental analysis; infrared and 1H NMR spectroscopy with 1H–1H COSY, ESI/TOF mass spectrometry and thermogravimetry. A study of the cytotoxicity of these compounds against the Hela cell line was carried out, with results indicating a low activity.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
钌(ii)和铱(iii)的新型半三明治配合物。研究它们对 Hela 的毒性
在这项工作中,我们描述了起始材料 [Cp*IrCl2]2 和四种新的钌(II)和铱(III)配合物半夹心的合成和表征:[Cp*IrCl2(2-氨基吡啶)] (I)、[Cp*IrCl2(4-氨基吡啶)] (II)、[Cp*IrCl2(腺嘌呤)] (III) 和 [(对伞花烃)RuCl2(腺嘌呤)] (IV)。新化合物的表征方法包括:C、H 和 N 元素分析;红外和 1H NMR 光谱及 1H-1H COSY、ESI/TOF 质谱分析和热重分析。对这些化合物对 Hela 细胞系的细胞毒性进行了研究,结果表明活性较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Pure and Applied Chemistry
Pure and Applied Chemistry 化学-化学综合
CiteScore
4.00
自引率
0.00%
发文量
60
审稿时长
3-8 weeks
期刊介绍: Pure and Applied Chemistry is the official monthly Journal of IUPAC, with responsibility for publishing works arising from those international scientific events and projects that are sponsored and undertaken by the Union. The policy is to publish highly topical and credible works at the forefront of all aspects of pure and applied chemistry, and the attendant goal is to promote widespread acceptance of the Journal as an authoritative and indispensable holding in academic and institutional libraries.
期刊最新文献
Removal of acidic dyes; acid yellow 25 and acid red 4 from wastewater by degassed activated carbon Molecular approach to semiconductors: a shift towards ecofriendly manufacturing and neuroinspired interfaces The impact of nanofiller composition and nature on the enhancement of mechanical and rheological properties of poly(lactic acid) (PLA) nanobiocomposite films is achieved by regulating the spacing of organic fillers and PLA crystallinity Green chemistry for all: three principles of Inclusive Green and Sustainable Chemistry Education The case of the disappearing energy: potential energies in concentration gradients
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1