A drug-loaded flexible substrate improves the performance of conformal cortical electrodes

IF 8.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Bio-Design and Manufacturing Pub Date : 2024-07-12 DOI:10.1007/s42242-024-00299-x

Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li, Wei Huang

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引用次数: 0

Abstract

皮质电极是刺激和/或记录神经系统电活动的有力工具. 然而, 外科植入电极所导致的不可避免的伤口带来了与外源性物质暴露相关的细菌感染和炎症反应风险. 此外, 伤口区域的炎症可能会因细菌感染而急剧恶化. 这些后果不仅可能导致皮质电极植入失败, 还可能威胁患者生命. 在此, 我们制备了负载抗生素四环素 (TC) 和抗炎药物地塞米松 (DEX) 的细菌纤维素 (BC) 水凝胶, 并将其作为皮质电极的柔性基底. 负载的药物可以从BC水凝胶中缓慢释放, 有效抑制革兰阴性和阳性细菌的生长. 进一步地, 通过将负载药物的BC水凝胶与九通道蛇形阵列集成, 开发了治疗性皮质电极, 并将其用于在大鼠模型中记录皮层脑电图 (ECoG) 信号. 由于TC和DEX可从BC水凝胶基底缓慢释放, 治疗性皮质电极可缓解或预防与大脑组织的细菌感染和炎症相关的症状. 该方法有助于药物递送电极的开发, 以解决由于植入电极所导致的并发症等问题.

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载药柔性基底可提高保形皮层电极的性能

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来源期刊

Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)

CiteScore

13.30

自引率

7.60%

发文量

148

期刊介绍： Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.