Engineering microbial metabolic homeostasis for chemicals production.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-07-14 DOI:10.1080/07388551.2024.2371465
Yang Li, Mingxiong Liu, Changyang Yang, Hongxin Fu, Jufang Wang
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Abstract

Microbial-based bio-refining promotes the development of a biotechnology revolution to encounter and tackle the enormous challenges in petroleum-based chemical production by biomanufacturing, biocomputing, and biosensing. Nevertheless, microbial metabolic homeostasis is often incompatible with the efficient synthesis of bioproducts mainly due to: inefficient metabolic flow, robust central metabolism, sophisticated metabolic network, and inevitable environmental perturbation. Therefore, this review systematically summarizes how to optimize microbial metabolic homeostasis by strengthening metabolic flux for improving biotransformation turnover, redirecting metabolic direction for rewiring bypass pathway, and reprogramming metabolic network for boosting substrate utilization. Future directions are also proposed for providing constructive guidance on the development of industrial biotechnology.

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为化学品生产设计微生物代谢平衡。
以微生物为基础的生物炼制促进了生物技术革命的发展,通过生物制造、生物计算和生物传感来应对和解决以石油为基础的化学品生产所面临的巨大挑战。然而,微生物的代谢平衡往往与生物产品的高效合成不相容,这主要是由于:低效的代谢流、强大的中心代谢、复杂的代谢网络以及不可避免的环境干扰。因此,本综述系统地总结了如何通过加强代谢通量以提高生物转化周转率、调整代谢方向以重构旁路通路、重新规划代谢网络以提高底物利用率来优化微生物的代谢平衡。研究还提出了未来的发展方向,为工业生物技术的发展提供建设性指导。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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