A comparison of brown fat tissue related hormone levels in metabolically healthy and unhealthy individuals with obesity.

IF 3.7 3区医学 Q2 Medicine Endocrine Pub Date : 2024-12-01 Epub Date: 2024-07-15 DOI:10.1007/s12020-024-03960-8

Hacer Hicran Mutlu, Saniye Koç Ada, Mehmet Uzunlulu, Hasan Hüseyin Mutlu, Mehmet Sargın, Aytekin Oğuz

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Abstract

Purpose: One of the key functions of brown adipose tissue is its positive impact on metabolism. This study aimed to examine the potential involvement of brown fat-related hormones in the development of metabolically healthy obesity. Specifically, we sought to compare the levels of NRG4, FGF21, and irisin between metabolically healthy and unhealthy individuals with obesity.

Methods: Patients with BMI ≥ 30 kg/m² and aged between 20 and 50 years were included in the study. Among these patients, those who did not have any metabolic syndrome criteria except for increased waist circumference were defined as metabolically healthy obese. Age, gender, BMI, body fat, and muscle mass, matched metabolically healthy and unhealthy obese groups were compared in terms of FGF21, irisin, and NRG4 levels.

Results: Metabolically healthy and unhealthy obese groups were similar in terms of age and gender. There was no difference between the two groups in terms of BMI, weight, total body fat, muscle, fat-free mass, distribution of body fat and muscle mass. No statistically significant difference was found between irisin, NRG4, and FGF21 levels between metabolically healthy and unhealthy individuals with obesity. It was found that irisin had a significant inverse correlation with BMI and body fat percentage.

Conclusion: The present study showed no difference between metabolically healthy and unhealthy obese individuals in terms of irisin, FGF21, and NRG4 levels. The weak association between irisin and BMI and body fat percentage may suggest a potential link between irisin with metabolic health.

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代谢健康和不健康的肥胖症患者体内棕色脂肪组织相关激素水平的比较。

目的：棕色脂肪组织的主要功能之一是对新陈代谢产生积极影响。本研究旨在探讨棕色脂肪相关激素在代谢健康型肥胖发展过程中的潜在参与作用。具体来说，我们试图比较代谢健康和不健康肥胖患者的 NRG4、FGF21 和鸢尾素水平：研究对象包括体重指数（BMI）≥ 30 kg/m2、年龄在 20 至 50 岁之间的患者。在这些患者中，除腰围增大外没有任何代谢综合征标准的患者被定义为代谢健康的肥胖者。研究人员比较了代谢健康肥胖组和不健康肥胖组在年龄、性别、体重指数、体脂和肌肉质量方面的 FGF21、鸢尾素和 NRG4 水平：结果：代谢健康肥胖组和不健康肥胖组在年龄和性别方面相似。两组在体重指数、体重、体脂总量、肌肉、去脂质量、体脂分布和肌肉质量方面没有差异。鸢尾素、NRG4 和 FGF21 的水平在代谢健康的肥胖者和代谢不健康的肥胖者之间没有统计学意义上的差异。研究发现，鸢尾素与体重指数（BMI）和体脂百分比呈显著负相关：本研究表明，代谢健康和不健康的肥胖者在鸢尾素、FGF21 和 NRG4 水平方面没有差异。鸢尾素与体重指数（BMI）和体脂率之间的微弱联系可能表明鸢尾素与代谢健康之间存在潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.