Frederick Dun-Dery PhD, MPhil , Jianling Xie MD, MPH , Kathleen Winston MSc , Brett Burstein MDCM, PhD, MPH , Jason Emsley MD, PhD , Vikram Sabhaney MD , Jocelyn Gravel MD, MSc , Roger Zemek MD , April Kam MD, MScPH , Ahmed Mater MD , Darcy Beer MD , Gabrielle Freire MDCM, MHSc , Naveen Poonai MD, MSc , Simon Berthelot MD, MSc , Robert Porter MD, MSc , Anne Moffatt MD , Marina Salvadori MD , Andrew Dixon MD , Stephen B. Freedman MDCM, MSc , on behalf of Pediatric Emergency Research Canada (PERC) COVID Study Group
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引用次数: 0
Abstract
Objective
To assess the association between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and long-term quality of life (QoL).
Methods
Prospective cohort study with 6- and 12-months follow-up conducted in 14 Canadian institutions. Children tested for SARS-CoV-2 between August 2020 and February 2022 were eligible. QoL was measured using PedsQL-4.0, overall health status scores 6- and 12-months after testing.
Results
Among SARS-CoV-2 positive and negative participants eligible for long-term follow-up, 74.8% (505/675) and 71.8% (1106/1541) at 6- and 59.0% (727/1233) and 68.1% (2520/3699) at 12-months, completed follow-up, respectively. Mean ± SD PedsQL scores did not differ between positive and negative groups; difference: −0.86 (95% CI: −2.33, 0.61) at 6- and −0.48 (95% CI: −1.6, 0.64) at 12-months, respectively. SARS-CoV-2 test-positivity was associated with higher social subscale scores. Although in bivariate analysis, overall health status at 6-months was higher among SARS-CoV-2 cases [difference: 2.16 (95% CI: 0.80, 3.53)], after adjustment for co-variates, SARS-CoV-2 infection was not independently associated with total PedsQL or overall health status at either time point. Parental perception of recovery did not differ based on SARS-CoV-2 test-status at either time point.
Conclusions
SARS-CoV-2 infection was not associated with QoL, overall health status, or parental perception of recovery 6- and 12-months following infection.
期刊介绍：
Academic Pediatrics, the official journal of the Academic Pediatric Association, is a peer-reviewed publication whose purpose is to strengthen the research and educational base of academic general pediatrics. The journal provides leadership in pediatric education, research, patient care and advocacy. Content areas include pediatric education, emergency medicine, injury, abuse, behavioral pediatrics, holistic medicine, child health services and health policy,and the environment. The journal provides an active forum for the presentation of pediatric educational research in diverse settings, involving medical students, residents, fellows, and practicing professionals. The journal also emphasizes important research relating to the quality of child health care, health care policy, and the organization of child health services. It also includes systematic reviews of primary care interventions and important methodologic papers to aid research in child health and education.
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