Incidence and patterns of lymph node metastases in head and neck rhabdomyosarcoma: One-institution study.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-07-14 DOI:10.1002/hed.27870

Tian Wang, Jie Wang, Qiang Li, Yi Li, Xinmao Song

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Abstract

Introduction: Head and neck rhabdomyosarcoma (HNRMS) is an aggressive malignant soft tissue tumor that easily develops lymph node metastasis (LNM) and distant metastasis. No literature investigates the pattern of LNM in HNRMS.

Methods: Ninety-five consecutive patients with HNRMS newly diagnosed at one institution between November 2011 and July 2023 were retrospectively reviewed. All the patients underwent head and neck contrast-enhanced MRI and/or CT, PET-CT if necessary. The associations between LNMs and clinical characteristics and histopathological parameters were discovered.

Results: 44.2% of patients had evidence of LNM at diagnosis, and the most common LNM occurred in the ipsilateral retropharyngeal space. The primary tumor metastasizes to the retropharyngeal space, and then next to level II is the most common LN drainage basin. In multivariate analysis, only distant metastasis determines the prognosis, other than LN status.

Conclusions: LNM has a high incidence in HNRMS and rarely causes contralateral metastasis for localized lesions or skip metastasis.

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头颈部横纹肌肉瘤淋巴结转移的发生率和模式：一个机构的研究。

前言头颈部横纹肌肉瘤（HNRMS）是一种侵袭性恶性软组织肿瘤，容易发生淋巴结转移（LNM）和远处转移。目前还没有文献研究 HNRMS 的淋巴结转移模式：方法：对2011年11月至2023年7月期间在一家医院新确诊的95例连续HNRMS患者进行回顾性研究。所有患者均接受了头颈部对比增强 MRI 和/或 CT 检查，必要时接受 PET-CT 检查。研究发现了LNMs与临床特征和组织病理学参数之间的关联：44.2%的患者在确诊时有LNM证据，最常见的LNM发生在同侧咽后间隙。原发肿瘤转移到咽后间隙后，Ⅱ级是最常见的LN引流盆地。在多变量分析中，除LN状态外，只有远处转移决定了预后：结论：LNM 在 HNRMS 中的发生率很高，很少引起局部病变的对侧转移或跳过转移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.