Association between a past history of nausea and vomiting during pregnancy and fever after the BNT162b2 COVID-19 vaccination.

IF 1.9 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Journal of oral science Pub Date : 2024-01-01 DOI:10.2334/josnusd.24-0080

Rie Fujiyama, Kaoru Fujiyama, Hiroaki Tada, Tadateru Sumi, Hiroyuki Moriuchi

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Abstract

Purpose: Nausea and vomiting during pregnancy (NVP) are common among pregnant women and can be severe enough to require hospitalization. However, the mechanism underlying NVP pathogenesis remains unclear. This study examined factors associated with adverse events after vaccination, including a past history of NVP.

Methods: A questionnaire-based survey was completed by non-pregnant women working at Nagasaki University Hospital who received two doses of the BNT162b2 coronavirus disease 2019 (COVID-19) vaccine. This study primarily examined the association between a past history of NVP and post-vaccination fever, as fever was determined to be the most objective and reliable indicator of the surveyed adverse events.

Results: Multivariate logistic regression analysis showed that post-vaccination fever was more strongly associated with a past history of NVP (odds ratio, 1.88; 95% confidence interval, 1.16-3.07) than either age (0.73; 0.56-0.96) or weight (0.85; 0.70-1.15), which were previously considered to be highly associated with the incidence of adverse events following COVID-19 vaccination.

Conclusion: These results suggest an involvement of a similar pathological condition in developing NVP and post-vaccination fever.

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既往妊娠期恶心和呕吐史与 BNT162b2 COVID-19 疫苗接种后发烧之间的关系。

目的：妊娠期恶心和呕吐（NVP）在孕妇中很常见，严重时甚至需要住院治疗。然而，NVP 的发病机制仍不清楚。本研究探讨了与接种疫苗后不良事件相关的因素，包括既往NVP病史：方法：在长崎大学医院工作、接种过两剂 BNT162b2 冠状病毒病 2019（COVID-19）疫苗的非孕妇完成了一项问卷调查。本研究主要考察了既往非传染性疾病史与接种后发热之间的关联，因为发热被认为是所调查的不良事件中最客观、最可靠的指标：多变量逻辑回归分析显示，接种后发热与既往NVP病史的相关性（几率比1.88；95%置信区间1.16-3.07）高于年龄（0.73；0.56-0.96）或体重（0.85；0.70-1.15），而年龄或体重曾被认为与COVID-19疫苗接种后不良事件的发生率高度相关：结论：这些结果表明，NVP和接种后发热的发生与相似的病理条件有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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